Augmentation of light therapy in difficult-to-treat depressed patients: an open-label trial in both unipolar and bipolar patients

Giovanni Camardese,1 Beniamino Leone,1 Riccardo Serrani,1 Coco Walstra,1 Marco Di Nicola,1 Giacomo Della Marca,2 Pietro Bria,1 Luigi Janiri1 1Institute of Psychiatry and Psychology, 2Institute of Neurology, Catholic University of the Sacred Heart, Rome, Italy Objectives: We investigated the clinic...

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Autores principales:	Camardese G, Leone B, Serrani R, Walstra C, Di Nicola M, Della Marca G, Bria P, Janiri L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/9342bb726d6c4e3a87656ccfb9c1a94c
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spelling	oai:doaj.org-article:9342bb726d6c4e3a87656ccfb9c1a94c2021-12-02T06:25:34ZAugmentation of light therapy in difficult-to-treat depressed patients: an open-label trial in both unipolar and bipolar patients1178-2021https://doaj.org/article/9342bb726d6c4e3a87656ccfb9c1a94c2015-09-01T00:00:00Zhttps://www.dovepress.com/augmentation-of-light-therapy-in-difficult-to-treat-depressed-patients-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Giovanni Camardese,1 Beniamino Leone,1 Riccardo Serrani,1 Coco Walstra,1 Marco Di Nicola,1 Giacomo Della Marca,2 Pietro Bria,1 Luigi Janiri1 1Institute of Psychiatry and Psychology, 2Institute of Neurology, Catholic University of the Sacred Heart, Rome, Italy Objectives: We investigated the clinical benefits of bright light therapy (BLT) as an adjunct treatment to ongoing psychopharmacotherapy, both in unipolar and bipolar difficult-to-treat depressed (DTD) outpatients.Methods: In an open-label study, 31 depressed outpatients (16 unipolar and 15 bipolar) were included to undergo 3 weeks of BLT. Twenty-five completed the treatment and 5-week follow-up.Main outcome measures: Clinical outcomes were evaluated by the Hamilton Depression Rating Scale (HDRS). The Snaith–Hamilton Pleasure Scale and the Depression Retardation Rating Scale were used to assess changes in anhedonia and psychomotor retardation, respectively.Results: The adjunctive BLT seemed to influence the course of the depressive episode, and a statistically significant reduction in HDRS scores was reported since the first week of therapy. The treatment was well-tolerated, and no patients presented clinical signs of (hypo)manic switch during the overall treatment period. At the end of the study (after 5 weeks from BLT discontinuation), nine patients (36%, eight unipolar and one bipolar) still showed a treatment response. BLT augmentation also led to a significant improvement of psychomotor retardation.Conclusion: BLT combined with the ongoing pharmacological treatment offers a simple approach, and it might be effective in rapidly ameliorating depressive core symptoms of vulnerable DTD outpatients. These preliminary results need to be confirmed in placebo-controlled, randomized, double-blind clinical trial on larger samples. Keywords: light therapy, unipolar depression, bipolar depression, anhedonia, psychomotor dysfunction  Camardese GLeone BSerrani RWalstra CDi Nicola MDella Marca GBria PJaniri LDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 2331-2338 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Camardese G Leone B Serrani R Walstra C Di Nicola M Della Marca G Bria P Janiri L Augmentation of light therapy in difficult-to-treat depressed patients: an open-label trial in both unipolar and bipolar patients
description	Giovanni Camardese,1 Beniamino Leone,1 Riccardo Serrani,1 Coco Walstra,1 Marco Di Nicola,1 Giacomo Della Marca,2 Pietro Bria,1 Luigi Janiri1 1Institute of Psychiatry and Psychology, 2Institute of Neurology, Catholic University of the Sacred Heart, Rome, Italy Objectives: We investigated the clinical benefits of bright light therapy (BLT) as an adjunct treatment to ongoing psychopharmacotherapy, both in unipolar and bipolar difficult-to-treat depressed (DTD) outpatients.Methods: In an open-label study, 31 depressed outpatients (16 unipolar and 15 bipolar) were included to undergo 3 weeks of BLT. Twenty-five completed the treatment and 5-week follow-up.Main outcome measures: Clinical outcomes were evaluated by the Hamilton Depression Rating Scale (HDRS). The Snaith–Hamilton Pleasure Scale and the Depression Retardation Rating Scale were used to assess changes in anhedonia and psychomotor retardation, respectively.Results: The adjunctive BLT seemed to influence the course of the depressive episode, and a statistically significant reduction in HDRS scores was reported since the first week of therapy. The treatment was well-tolerated, and no patients presented clinical signs of (hypo)manic switch during the overall treatment period. At the end of the study (after 5 weeks from BLT discontinuation), nine patients (36%, eight unipolar and one bipolar) still showed a treatment response. BLT augmentation also led to a significant improvement of psychomotor retardation.Conclusion: BLT combined with the ongoing pharmacological treatment offers a simple approach, and it might be effective in rapidly ameliorating depressive core symptoms of vulnerable DTD outpatients. These preliminary results need to be confirmed in placebo-controlled, randomized, double-blind clinical trial on larger samples. Keywords: light therapy, unipolar depression, bipolar depression, anhedonia, psychomotor dysfunction
format	article
author	Camardese G Leone B Serrani R Walstra C Di Nicola M Della Marca G Bria P Janiri L
author_facet	Camardese G Leone B Serrani R Walstra C Di Nicola M Della Marca G Bria P Janiri L
author_sort	Camardese G
title	Augmentation of light therapy in difficult-to-treat depressed patients: an open-label trial in both unipolar and bipolar patients
title_short	Augmentation of light therapy in difficult-to-treat depressed patients: an open-label trial in both unipolar and bipolar patients
title_full	Augmentation of light therapy in difficult-to-treat depressed patients: an open-label trial in both unipolar and bipolar patients
title_fullStr	Augmentation of light therapy in difficult-to-treat depressed patients: an open-label trial in both unipolar and bipolar patients
title_full_unstemmed	Augmentation of light therapy in difficult-to-treat depressed patients: an open-label trial in both unipolar and bipolar patients
title_sort	augmentation of light therapy in difficult-to-treat depressed patients: an open-label trial in both unipolar and bipolar patients
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/9342bb726d6c4e3a87656ccfb9c1a94c
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Augmentation of light therapy in difficult-to-treat depressed patients: an open-label trial in both unipolar and bipolar patients

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