A rare variant of African ancestry activates 8q24 lncRNA hub by modulating cancer associated enhancer

Genetic variants on chromosome 8q24 are associated with prostate cancer risk in men of African ancestry. Here the authors show that one of these variants, rs72725854 alters the enhancer activity in its region, which upon androgen stimulation, activates multiple oncogenic lncRNAs and c-myc.

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Autores principales:	Kaivalya Walavalkar, Bharath Saravanan, Anurag Kumar Singh, Ranveer Singh Jayani, Ashwin Nair, Umer Farooq, Zubairul Islam, Deepanshu Soota, Rajat Mann, Padubidri V. Shivaprasad, Matthew L. Freedman, Radhakrishnan Sabarinathan, Christopher A. Haiman, Dimple Notani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/93438dabdd644b0eb1657d432722a153
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spelling	oai:doaj.org-article:93438dabdd644b0eb1657d432722a1532021-12-02T18:36:59ZA rare variant of African ancestry activates 8q24 lncRNA hub by modulating cancer associated enhancer10.1038/s41467-020-17325-y2041-1723https://doaj.org/article/93438dabdd644b0eb1657d432722a1532020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17325-yhttps://doaj.org/toc/2041-1723Genetic variants on chromosome 8q24 are associated with prostate cancer risk in men of African ancestry. Here the authors show that one of these variants, rs72725854 alters the enhancer activity in its region, which upon androgen stimulation, activates multiple oncogenic lncRNAs and c-myc.Kaivalya WalavalkarBharath SaravananAnurag Kumar SinghRanveer Singh JayaniAshwin NairUmer FarooqZubairul IslamDeepanshu SootaRajat MannPadubidri V. ShivaprasadMatthew L. FreedmanRadhakrishnan SabarinathanChristopher A. HaimanDimple NotaniNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kaivalya Walavalkar Bharath Saravanan Anurag Kumar Singh Ranveer Singh Jayani Ashwin Nair Umer Farooq Zubairul Islam Deepanshu Soota Rajat Mann Padubidri V. Shivaprasad Matthew L. Freedman Radhakrishnan Sabarinathan Christopher A. Haiman Dimple Notani A rare variant of African ancestry activates 8q24 lncRNA hub by modulating cancer associated enhancer
description	Genetic variants on chromosome 8q24 are associated with prostate cancer risk in men of African ancestry. Here the authors show that one of these variants, rs72725854 alters the enhancer activity in its region, which upon androgen stimulation, activates multiple oncogenic lncRNAs and c-myc.
format	article
author	Kaivalya Walavalkar Bharath Saravanan Anurag Kumar Singh Ranveer Singh Jayani Ashwin Nair Umer Farooq Zubairul Islam Deepanshu Soota Rajat Mann Padubidri V. Shivaprasad Matthew L. Freedman Radhakrishnan Sabarinathan Christopher A. Haiman Dimple Notani
author_facet	Kaivalya Walavalkar Bharath Saravanan Anurag Kumar Singh Ranveer Singh Jayani Ashwin Nair Umer Farooq Zubairul Islam Deepanshu Soota Rajat Mann Padubidri V. Shivaprasad Matthew L. Freedman Radhakrishnan Sabarinathan Christopher A. Haiman Dimple Notani
author_sort	Kaivalya Walavalkar
title	A rare variant of African ancestry activates 8q24 lncRNA hub by modulating cancer associated enhancer
title_short	A rare variant of African ancestry activates 8q24 lncRNA hub by modulating cancer associated enhancer
title_full	A rare variant of African ancestry activates 8q24 lncRNA hub by modulating cancer associated enhancer
title_fullStr	A rare variant of African ancestry activates 8q24 lncRNA hub by modulating cancer associated enhancer
title_full_unstemmed	A rare variant of African ancestry activates 8q24 lncRNA hub by modulating cancer associated enhancer
title_sort	rare variant of african ancestry activates 8q24 lncrna hub by modulating cancer associated enhancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/93438dabdd644b0eb1657d432722a153
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A rare variant of African ancestry activates 8q24 lncRNA hub by modulating cancer associated enhancer

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