A rare variant of African ancestry activates 8q24 lncRNA hub by modulating cancer associated enhancer

A rare variant of African ancestry activates 8q24 lncRNA hub by modulating cancer associated enhancer

Genetic variants on chromosome 8q24 are associated with prostate cancer risk in men of African ancestry. Here the authors show that one of these variants, rs72725854 alters the enhancer activity in its region, which upon androgen stimulation, activates multiple oncogenic lncRNAs and c-myc.

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Autores principales: Kaivalya Walavalkar, Bharath Saravanan, Anurag Kumar Singh, Ranveer Singh Jayani, Ashwin Nair, Umer Farooq, Zubairul Islam, Deepanshu Soota, Rajat Mann, Padubidri V. Shivaprasad, Matthew L. Freedman, Radhakrishnan Sabarinathan, Christopher A. Haiman, Dimple Notani
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/93438dabdd644b0eb1657d432722a153
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