Fabrication and properties of PLA/nano-HA composite scaffolds with balanced mechanical properties and biological functions for bone tissue engineering application

Repair of critical bone defects is a challenge in the orthopedic clinic. 3D printing is an advanced personalized manufacturing technology that can accurately shape internal structures and external contours. In this study, the composite scaffolds of polylactic acid (PLA) and nano-hydroxyapatite (n-HA...

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Autores principales:	Wang Wenzhao, Zhang Boqing, Zhao Lihong, Li Mingxin, Han Yanlong, Wang Li, Zhang Zhengdong, Li Jun, Zhou Changchun, Liu Lei
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	3d printing polylactic acid nano-hydroxyapatite bone defect composited biomaterials Technology T Chemical technology TP1-1185 Physical and theoretical chemistry QD450-801
Acceso en línea:	https://doaj.org/article/9343cd3c28114bfb90546beb2ff1d4a4
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spelling	oai:doaj.org-article:9343cd3c28114bfb90546beb2ff1d4a42021-12-05T14:10:58ZFabrication and properties of PLA/nano-HA composite scaffolds with balanced mechanical properties and biological functions for bone tissue engineering application2191-909710.1515/ntrev-2021-0083https://doaj.org/article/9343cd3c28114bfb90546beb2ff1d4a42021-10-01T00:00:00Zhttps://doi.org/10.1515/ntrev-2021-0083https://doaj.org/toc/2191-9097Repair of critical bone defects is a challenge in the orthopedic clinic. 3D printing is an advanced personalized manufacturing technology that can accurately shape internal structures and external contours. In this study, the composite scaffolds of polylactic acid (PLA) and nano-hydroxyapatite (n-HA) were manufactured by the fused deposition modeling (FDM) technique. Equal mass PLA and n-HA were uniformly mixed to simulate the organic and inorganic phases of natural bone. The suitability of the composite scaffolds was evaluated by material characterization, mechanical property, and in vitro biocompatibility, and the osteogenesis induction in vitro was further tested. Finally, the printed scaffold was implanted into the rabbit femoral defect model to evaluate the osteogenic ability in vivo. The results showed that the composite scaffold had sufficient mechanical strength, appropriate pore size, and biocompatibility. Most importantly, the osteogenic induction performance of the composite scaffold was significantly better than that of the pure PLA scaffold. In conclusion, the PLA/n-HA scaffold is a promising composite biomaterial for bone defect repair and has excellent clinical transformation potential.Wang WenzhaoZhang BoqingZhao LihongLi MingxinHan YanlongWang LiZhang ZhengdongLi JunZhou ChangchunLiu LeiDe Gruyterarticle3d printingpolylactic acidnano-hydroxyapatitebone defectcomposited biomaterialsTechnologyTChemical technologyTP1-1185Physical and theoretical chemistryQD450-801ENNanotechnology Reviews, Vol 10, Iss 1, Pp 1359-1373 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	3d printing polylactic acid nano-hydroxyapatite bone defect composited biomaterials Technology T Chemical technology TP1-1185 Physical and theoretical chemistry QD450-801
spellingShingle	3d printing polylactic acid nano-hydroxyapatite bone defect composited biomaterials Technology T Chemical technology TP1-1185 Physical and theoretical chemistry QD450-801 Wang Wenzhao Zhang Boqing Zhao Lihong Li Mingxin Han Yanlong Wang Li Zhang Zhengdong Li Jun Zhou Changchun Liu Lei Fabrication and properties of PLA/nano-HA composite scaffolds with balanced mechanical properties and biological functions for bone tissue engineering application
description	Repair of critical bone defects is a challenge in the orthopedic clinic. 3D printing is an advanced personalized manufacturing technology that can accurately shape internal structures and external contours. In this study, the composite scaffolds of polylactic acid (PLA) and nano-hydroxyapatite (n-HA) were manufactured by the fused deposition modeling (FDM) technique. Equal mass PLA and n-HA were uniformly mixed to simulate the organic and inorganic phases of natural bone. The suitability of the composite scaffolds was evaluated by material characterization, mechanical property, and in vitro biocompatibility, and the osteogenesis induction in vitro was further tested. Finally, the printed scaffold was implanted into the rabbit femoral defect model to evaluate the osteogenic ability in vivo. The results showed that the composite scaffold had sufficient mechanical strength, appropriate pore size, and biocompatibility. Most importantly, the osteogenic induction performance of the composite scaffold was significantly better than that of the pure PLA scaffold. In conclusion, the PLA/n-HA scaffold is a promising composite biomaterial for bone defect repair and has excellent clinical transformation potential.
format	article
author	Wang Wenzhao Zhang Boqing Zhao Lihong Li Mingxin Han Yanlong Wang Li Zhang Zhengdong Li Jun Zhou Changchun Liu Lei
author_facet	Wang Wenzhao Zhang Boqing Zhao Lihong Li Mingxin Han Yanlong Wang Li Zhang Zhengdong Li Jun Zhou Changchun Liu Lei
author_sort	Wang Wenzhao
title	Fabrication and properties of PLA/nano-HA composite scaffolds with balanced mechanical properties and biological functions for bone tissue engineering application
title_short	Fabrication and properties of PLA/nano-HA composite scaffolds with balanced mechanical properties and biological functions for bone tissue engineering application
title_full	Fabrication and properties of PLA/nano-HA composite scaffolds with balanced mechanical properties and biological functions for bone tissue engineering application
title_fullStr	Fabrication and properties of PLA/nano-HA composite scaffolds with balanced mechanical properties and biological functions for bone tissue engineering application
title_full_unstemmed	Fabrication and properties of PLA/nano-HA composite scaffolds with balanced mechanical properties and biological functions for bone tissue engineering application
title_sort	fabrication and properties of pla/nano-ha composite scaffolds with balanced mechanical properties and biological functions for bone tissue engineering application
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/9343cd3c28114bfb90546beb2ff1d4a4
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Fabrication and properties of PLA/nano-HA composite scaffolds with balanced mechanical properties and biological functions for bone tissue engineering application

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