Establishment of a Controlled Human Infection Model with a Lyophilized Strain of <named-content content-type="genus-species">Shigella sonnei</named-content> 53G

Establishment of a Controlled Human Infection Model with a Lyophilized Strain of <named-content content-type="genus-species">Shigella sonnei</named-content> 53G

ABSTRACT Controlled human infection models (CHIMs) are useful for vaccine development. To improve on existing models, we developed a CHIM using a lyophilized preparation of Shigella sonnei strain 53G produced using current good manufacturing practice (cGMP). Healthy adults were enrolled in an open-l...

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Bibliographic Details
Main Authors: Robert W. Frenck, Michelle Dickey, Akamol E. Suvarnapunya, Lakshmi Chandrasekaran, Robert W. Kaminski, Kristen A. Clarkson, Monica McNeal, Amanda Lynen, Susan Parker, Amy Hoeper, Sachin Mani, Alan Fix, Nicole Maier, Malabi M. Venkatesan, Chad K. Porter
Format: article
Language:EN
Published: American Society for Microbiology 2020
Subjects:
controlled human infection models
shigellosis
Shigella
diarrhea
enteric disease
human challenge
Microbiology
QR1-502
Online Access:https://doaj.org/article/93466a6d389e45019b54871b82a4c79c
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https://doaj.org/article/93466a6d389e45019b54871b82a4c79c

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