Therapeutic effects of micro-RNAs in preclinical studies of acute kidney injury: a systematic review and meta-analysis

Abstract AKI has a high mortality rate, may lead to chronic kidney disease, and effective therapies are lacking. Micro-RNAs (miRNAs) regulate biologic processes by potently inhibiting protein expression, and pre-clinical studies have explored their roles in AKI. We conducted a systematic review and...

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Autores principales:	Sarah Zankar, Mayra Trentin-Sonoda, Jose L. Viñas, Rosendo A. Rodriguez, Adrian Bailey, David Allan, Kevin D. Burns
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/934689081d0644ea8ebe3c6a87dec35c
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spelling	oai:doaj.org-article:934689081d0644ea8ebe3c6a87dec35c2021-12-02T17:14:58ZTherapeutic effects of micro-RNAs in preclinical studies of acute kidney injury: a systematic review and meta-analysis10.1038/s41598-021-88746-y2045-2322https://doaj.org/article/934689081d0644ea8ebe3c6a87dec35c2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88746-yhttps://doaj.org/toc/2045-2322Abstract AKI has a high mortality rate, may lead to chronic kidney disease, and effective therapies are lacking. Micro-RNAs (miRNAs) regulate biologic processes by potently inhibiting protein expression, and pre-clinical studies have explored their roles in AKI. We conducted a systematic review and meta-analysis of miRNAs as therapeutics in pre-clinical AKI. Study screening, data extraction, and quality assessments were performed by 2 independent reviewers. Seventy studies involving 42 miRNA species were included in the analysis. All studies demonstrated significant effects of the miRNA intervention on kidney function and/or histology, with most implicating apoptosis and phosphatase and tensin homolog (PTEN) signaling. Fourteen studies (20.0%) examined the effect of miRNA-21 in AKI, and meta-analysis demonstrated significant increases in serum creatinine and kidney injury scores with miR-21 antagonism and pre-conditioning. No studies reported on adverse effects of miRNA therapy. Limitations also included lack of model diversity (100% rodents, 61.4% ischemia–reperfusion injury), and predominance of male sex (78.6%). Most studies had an unclear risk of bias, and the majority of miRNA-21 studies were conducted by a single team of investigators. In summary, several miRNAs target kidney function and apoptosis in pre-clinical AKI models, with data suggesting that miRNA-21 may mediate protection and kidney repair. Systematic review registration ID: CRD42019128854.Sarah ZankarMayra Trentin-SonodaJose L. ViñasRosendo A. RodriguezAdrian BaileyDavid AllanKevin D. BurnsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sarah Zankar Mayra Trentin-Sonoda Jose L. Viñas Rosendo A. Rodriguez Adrian Bailey David Allan Kevin D. Burns Therapeutic effects of micro-RNAs in preclinical studies of acute kidney injury: a systematic review and meta-analysis
description	Abstract AKI has a high mortality rate, may lead to chronic kidney disease, and effective therapies are lacking. Micro-RNAs (miRNAs) regulate biologic processes by potently inhibiting protein expression, and pre-clinical studies have explored their roles in AKI. We conducted a systematic review and meta-analysis of miRNAs as therapeutics in pre-clinical AKI. Study screening, data extraction, and quality assessments were performed by 2 independent reviewers. Seventy studies involving 42 miRNA species were included in the analysis. All studies demonstrated significant effects of the miRNA intervention on kidney function and/or histology, with most implicating apoptosis and phosphatase and tensin homolog (PTEN) signaling. Fourteen studies (20.0%) examined the effect of miRNA-21 in AKI, and meta-analysis demonstrated significant increases in serum creatinine and kidney injury scores with miR-21 antagonism and pre-conditioning. No studies reported on adverse effects of miRNA therapy. Limitations also included lack of model diversity (100% rodents, 61.4% ischemia–reperfusion injury), and predominance of male sex (78.6%). Most studies had an unclear risk of bias, and the majority of miRNA-21 studies were conducted by a single team of investigators. In summary, several miRNAs target kidney function and apoptosis in pre-clinical AKI models, with data suggesting that miRNA-21 may mediate protection and kidney repair. Systematic review registration ID: CRD42019128854.
format	article
author	Sarah Zankar Mayra Trentin-Sonoda Jose L. Viñas Rosendo A. Rodriguez Adrian Bailey David Allan Kevin D. Burns
author_facet	Sarah Zankar Mayra Trentin-Sonoda Jose L. Viñas Rosendo A. Rodriguez Adrian Bailey David Allan Kevin D. Burns
author_sort	Sarah Zankar
title	Therapeutic effects of micro-RNAs in preclinical studies of acute kidney injury: a systematic review and meta-analysis
title_short	Therapeutic effects of micro-RNAs in preclinical studies of acute kidney injury: a systematic review and meta-analysis
title_full	Therapeutic effects of micro-RNAs in preclinical studies of acute kidney injury: a systematic review and meta-analysis
title_fullStr	Therapeutic effects of micro-RNAs in preclinical studies of acute kidney injury: a systematic review and meta-analysis
title_full_unstemmed	Therapeutic effects of micro-RNAs in preclinical studies of acute kidney injury: a systematic review and meta-analysis
title_sort	therapeutic effects of micro-rnas in preclinical studies of acute kidney injury: a systematic review and meta-analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/934689081d0644ea8ebe3c6a87dec35c
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Therapeutic effects of micro-RNAs in preclinical studies of acute kidney injury: a systematic review and meta-analysis

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