Therapeutic effects of micro-RNAs in preclinical studies of acute kidney injury: a systematic review and meta-analysis
Abstract AKI has a high mortality rate, may lead to chronic kidney disease, and effective therapies are lacking. Micro-RNAs (miRNAs) regulate biologic processes by potently inhibiting protein expression, and pre-clinical studies have explored their roles in AKI. We conducted a systematic review and...
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2021
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oai:doaj.org-article:934689081d0644ea8ebe3c6a87dec35c2021-12-02T17:14:58ZTherapeutic effects of micro-RNAs in preclinical studies of acute kidney injury: a systematic review and meta-analysis10.1038/s41598-021-88746-y2045-2322https://doaj.org/article/934689081d0644ea8ebe3c6a87dec35c2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88746-yhttps://doaj.org/toc/2045-2322Abstract AKI has a high mortality rate, may lead to chronic kidney disease, and effective therapies are lacking. Micro-RNAs (miRNAs) regulate biologic processes by potently inhibiting protein expression, and pre-clinical studies have explored their roles in AKI. We conducted a systematic review and meta-analysis of miRNAs as therapeutics in pre-clinical AKI. Study screening, data extraction, and quality assessments were performed by 2 independent reviewers. Seventy studies involving 42 miRNA species were included in the analysis. All studies demonstrated significant effects of the miRNA intervention on kidney function and/or histology, with most implicating apoptosis and phosphatase and tensin homolog (PTEN) signaling. Fourteen studies (20.0%) examined the effect of miRNA-21 in AKI, and meta-analysis demonstrated significant increases in serum creatinine and kidney injury scores with miR-21 antagonism and pre-conditioning. No studies reported on adverse effects of miRNA therapy. Limitations also included lack of model diversity (100% rodents, 61.4% ischemia–reperfusion injury), and predominance of male sex (78.6%). Most studies had an unclear risk of bias, and the majority of miRNA-21 studies were conducted by a single team of investigators. In summary, several miRNAs target kidney function and apoptosis in pre-clinical AKI models, with data suggesting that miRNA-21 may mediate protection and kidney repair. Systematic review registration ID: CRD42019128854.Sarah ZankarMayra Trentin-SonodaJose L. ViñasRosendo A. RodriguezAdrian BaileyDavid AllanKevin D. BurnsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) |
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Medicine R Science Q Sarah Zankar Mayra Trentin-Sonoda Jose L. Viñas Rosendo A. Rodriguez Adrian Bailey David Allan Kevin D. Burns Therapeutic effects of micro-RNAs in preclinical studies of acute kidney injury: a systematic review and meta-analysis |
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Abstract AKI has a high mortality rate, may lead to chronic kidney disease, and effective therapies are lacking. Micro-RNAs (miRNAs) regulate biologic processes by potently inhibiting protein expression, and pre-clinical studies have explored their roles in AKI. We conducted a systematic review and meta-analysis of miRNAs as therapeutics in pre-clinical AKI. Study screening, data extraction, and quality assessments were performed by 2 independent reviewers. Seventy studies involving 42 miRNA species were included in the analysis. All studies demonstrated significant effects of the miRNA intervention on kidney function and/or histology, with most implicating apoptosis and phosphatase and tensin homolog (PTEN) signaling. Fourteen studies (20.0%) examined the effect of miRNA-21 in AKI, and meta-analysis demonstrated significant increases in serum creatinine and kidney injury scores with miR-21 antagonism and pre-conditioning. No studies reported on adverse effects of miRNA therapy. Limitations also included lack of model diversity (100% rodents, 61.4% ischemia–reperfusion injury), and predominance of male sex (78.6%). Most studies had an unclear risk of bias, and the majority of miRNA-21 studies were conducted by a single team of investigators. In summary, several miRNAs target kidney function and apoptosis in pre-clinical AKI models, with data suggesting that miRNA-21 may mediate protection and kidney repair. Systematic review registration ID: CRD42019128854. |
format |
article |
author |
Sarah Zankar Mayra Trentin-Sonoda Jose L. Viñas Rosendo A. Rodriguez Adrian Bailey David Allan Kevin D. Burns |
author_facet |
Sarah Zankar Mayra Trentin-Sonoda Jose L. Viñas Rosendo A. Rodriguez Adrian Bailey David Allan Kevin D. Burns |
author_sort |
Sarah Zankar |
title |
Therapeutic effects of micro-RNAs in preclinical studies of acute kidney injury: a systematic review and meta-analysis |
title_short |
Therapeutic effects of micro-RNAs in preclinical studies of acute kidney injury: a systematic review and meta-analysis |
title_full |
Therapeutic effects of micro-RNAs in preclinical studies of acute kidney injury: a systematic review and meta-analysis |
title_fullStr |
Therapeutic effects of micro-RNAs in preclinical studies of acute kidney injury: a systematic review and meta-analysis |
title_full_unstemmed |
Therapeutic effects of micro-RNAs in preclinical studies of acute kidney injury: a systematic review and meta-analysis |
title_sort |
therapeutic effects of micro-rnas in preclinical studies of acute kidney injury: a systematic review and meta-analysis |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/934689081d0644ea8ebe3c6a87dec35c |
work_keys_str_mv |
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