Splenic marginal zone lymphoma: a review of the clinical presentation, pathology, molecular biology, and management

Larissa Sena Teixeira Mendes,1 Ming-Qing Du,2 Estella Matutes,3 Andrew Wotherspoon11Histopathology Department, Royal Marsden Hospital, London, UK; 2Molecular Malignancy Laboratory and Department of Histopathology, University Hospital NHS Foundation Trust/Division of Molecular Histopathology, Depart...

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Autores principales:	Teixeira Mendes LS, Du MQ, Matutes E, Wotherspoon A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/934921f055d04fdcabd27e7ea0acb0fc
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spelling	oai:doaj.org-article:934921f055d04fdcabd27e7ea0acb0fc2021-12-02T03:33:01ZSplenic marginal zone lymphoma: a review of the clinical presentation, pathology, molecular biology, and management1179-9889https://doaj.org/article/934921f055d04fdcabd27e7ea0acb0fc2014-07-01T00:00:00Zhttp://www.dovepress.com/splenic-marginal-zone-lymphoma-a-review-of-the-clinical-presentation-p-peer-reviewed-article-BLCTThttps://doaj.org/toc/1179-9889 Larissa Sena Teixeira Mendes,1 Ming-Qing Du,2 Estella Matutes,3 Andrew Wotherspoon11Histopathology Department, Royal Marsden Hospital, London, UK; 2Molecular Malignancy Laboratory and Department of Histopathology, University Hospital NHS Foundation Trust/Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, UK; 3Hematopathology Unit, Hospital Clinic, Barcelona University, Barcelona, Spain Abstract: Splenic marginal zone lymphoma is a distinct low grade B-cell lymphoma primarily occurring in the spleen and separate from nodal marginal zone lymphoma and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue. It is characterized by a relative indolent course, splenomegaly, moderate lymphocytosis, and an intrasinusoidal pattern of involvement, especially in the bone marrow. It is postulated that the neoplastic clone originates from persistent antigenic stimulation of marginal zone B-cells. Molecular and cytogenetic studies have failed to show specific alterations. There is no standard criterion to initiate treatment, which may include a watch and wait policy, splenectomy, or chemo/immunotherapy. This review highlights the main features of this entity, reassessing the guidelines for diagnosis, prognostic factors, staging, and management published by the SMZL Working Group (2008). Keywords: splenectomy, villous lymphocytes, guidelinesTeixeira Mendes LSDu MQMatutes EWotherspoon ADove Medical PressarticleDiseases of the blood and blood-forming organsRC633-647.5ENBlood and Lymphatic Cancer: Targets and Therapy, Vol 2014, Iss default, Pp 29-38 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Diseases of the blood and blood-forming organs RC633-647.5 Teixeira Mendes LS Du MQ Matutes E Wotherspoon A Splenic marginal zone lymphoma: a review of the clinical presentation, pathology, molecular biology, and management
description	Larissa Sena Teixeira Mendes,1 Ming-Qing Du,2 Estella Matutes,3 Andrew Wotherspoon11Histopathology Department, Royal Marsden Hospital, London, UK; 2Molecular Malignancy Laboratory and Department of Histopathology, University Hospital NHS Foundation Trust/Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, UK; 3Hematopathology Unit, Hospital Clinic, Barcelona University, Barcelona, Spain Abstract: Splenic marginal zone lymphoma is a distinct low grade B-cell lymphoma primarily occurring in the spleen and separate from nodal marginal zone lymphoma and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue. It is characterized by a relative indolent course, splenomegaly, moderate lymphocytosis, and an intrasinusoidal pattern of involvement, especially in the bone marrow. It is postulated that the neoplastic clone originates from persistent antigenic stimulation of marginal zone B-cells. Molecular and cytogenetic studies have failed to show specific alterations. There is no standard criterion to initiate treatment, which may include a watch and wait policy, splenectomy, or chemo/immunotherapy. This review highlights the main features of this entity, reassessing the guidelines for diagnosis, prognostic factors, staging, and management published by the SMZL Working Group (2008). Keywords: splenectomy, villous lymphocytes, guidelines
format	article
author	Teixeira Mendes LS Du MQ Matutes E Wotherspoon A
author_facet	Teixeira Mendes LS Du MQ Matutes E Wotherspoon A
author_sort	Teixeira Mendes LS
title	Splenic marginal zone lymphoma: a review of the clinical presentation, pathology, molecular biology, and management
title_short	Splenic marginal zone lymphoma: a review of the clinical presentation, pathology, molecular biology, and management
title_full	Splenic marginal zone lymphoma: a review of the clinical presentation, pathology, molecular biology, and management
title_fullStr	Splenic marginal zone lymphoma: a review of the clinical presentation, pathology, molecular biology, and management
title_full_unstemmed	Splenic marginal zone lymphoma: a review of the clinical presentation, pathology, molecular biology, and management
title_sort	splenic marginal zone lymphoma: a review of the clinical presentation, pathology, molecular biology, and management
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/934921f055d04fdcabd27e7ea0acb0fc
work_keys_str_mv	AT teixeiramendesls splenicmarginalzonelymphomaareviewoftheclinicalpresentationpathologymolecularbiologyandmanagement AT dumq splenicmarginalzonelymphomaareviewoftheclinicalpresentationpathologymolecularbiologyandmanagement AT matutese splenicmarginalzonelymphomaareviewoftheclinicalpresentationpathologymolecularbiologyandmanagement AT wotherspoona splenicmarginalzonelymphomaareviewoftheclinicalpresentationpathologymolecularbiologyandmanagement
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Splenic marginal zone lymphoma: a review of the clinical presentation, pathology, molecular biology, and management

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