Circulating sTweak is associated with visceral adiposity and severity in patients with obstructive sleep apnea syndrome

Abstract Hypoxia is linked to an inflammatory imbalance in obstructive sleep apnea syndrome (OSAS). Circulating soluble tumor necrosis factor (TNF)-like weak inducer of apoptosis (sTWEAK) is a cytokine that regulates inflammation and insulin resistance in adipose tissue. This study first investigate...

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Autores principales:	Sule Cilekar, Selvihan Beysel, Savas Karatas, Aydin Balci, Kursad Akaslan, Ali Uncu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/934ff3441a494333b0bcd55fa2029fb1
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spelling	oai:doaj.org-article:934ff3441a494333b0bcd55fa2029fb12021-11-14T12:17:56ZCirculating sTweak is associated with visceral adiposity and severity in patients with obstructive sleep apnea syndrome10.1038/s41598-021-01553-32045-2322https://doaj.org/article/934ff3441a494333b0bcd55fa2029fb12021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01553-3https://doaj.org/toc/2045-2322Abstract Hypoxia is linked to an inflammatory imbalance in obstructive sleep apnea syndrome (OSAS). Circulating soluble tumor necrosis factor (TNF)-like weak inducer of apoptosis (sTWEAK) is a cytokine that regulates inflammation and insulin resistance in adipose tissue. This study first investigated sTWEAK concentrations in patients OSAS and evaluated associations between sTWEAK concentrations and visceral adiposity, metabolic dysfunction, and hypoxia observed in OSAS. Forty age, sex, and body mass index-matched patients with simple habitual snoring (HSS) and 70 patients with OSAS were included. Patients were divided according to OSAS severity: mild-moderate (apnea–hypopnea index, AHI 5–30 events/h) and severe (AHI ≥ 30 events/h). Anthropometric data, glucose metabolism, visceral fat (VF) ratio, and sTWEAK levels were compared. sTWEAK levels were higher in the OSAS group than in the HSS group (931.23 ± 136.48 vs. 735.22 ± 102.84 ng/L, p = 0.001). sTWEAK levels were higher in severe OSAS than in mild-moderate OSAS (1031.83 ± 146.69 vs. 891.01 ± 110.01 ng/L, p = 0.002. When we evaluated the sTWEAK value and AHI, VF ratio, total cholesterol, blood pressure, homeostasis model of assessment-insulin resistance, and high-sensitivity C-reactive protein using multiple regression analysis, a significant correlation was found between sTWEAK levels and AHI (p < 0.001). It was found that sTWEAK levels were not correlated with glucose metabolism and VF ratio. Increased circulating sTWEAK levels were associated with the severity of OSAS. High sTWEAK levels were correlated with increased AHI. sTWEAK concentrations are linked to severe OSAS.Sule CilekarSelvihan BeyselSavas KaratasAydin BalciKursad AkaslanAli UncuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sule Cilekar Selvihan Beysel Savas Karatas Aydin Balci Kursad Akaslan Ali Uncu Circulating sTweak is associated with visceral adiposity and severity in patients with obstructive sleep apnea syndrome
description	Abstract Hypoxia is linked to an inflammatory imbalance in obstructive sleep apnea syndrome (OSAS). Circulating soluble tumor necrosis factor (TNF)-like weak inducer of apoptosis (sTWEAK) is a cytokine that regulates inflammation and insulin resistance in adipose tissue. This study first investigated sTWEAK concentrations in patients OSAS and evaluated associations between sTWEAK concentrations and visceral adiposity, metabolic dysfunction, and hypoxia observed in OSAS. Forty age, sex, and body mass index-matched patients with simple habitual snoring (HSS) and 70 patients with OSAS were included. Patients were divided according to OSAS severity: mild-moderate (apnea–hypopnea index, AHI 5–30 events/h) and severe (AHI ≥ 30 events/h). Anthropometric data, glucose metabolism, visceral fat (VF) ratio, and sTWEAK levels were compared. sTWEAK levels were higher in the OSAS group than in the HSS group (931.23 ± 136.48 vs. 735.22 ± 102.84 ng/L, p = 0.001). sTWEAK levels were higher in severe OSAS than in mild-moderate OSAS (1031.83 ± 146.69 vs. 891.01 ± 110.01 ng/L, p = 0.002. When we evaluated the sTWEAK value and AHI, VF ratio, total cholesterol, blood pressure, homeostasis model of assessment-insulin resistance, and high-sensitivity C-reactive protein using multiple regression analysis, a significant correlation was found between sTWEAK levels and AHI (p < 0.001). It was found that sTWEAK levels were not correlated with glucose metabolism and VF ratio. Increased circulating sTWEAK levels were associated with the severity of OSAS. High sTWEAK levels were correlated with increased AHI. sTWEAK concentrations are linked to severe OSAS.
format	article
author	Sule Cilekar Selvihan Beysel Savas Karatas Aydin Balci Kursad Akaslan Ali Uncu
author_facet	Sule Cilekar Selvihan Beysel Savas Karatas Aydin Balci Kursad Akaslan Ali Uncu
author_sort	Sule Cilekar
title	Circulating sTweak is associated with visceral adiposity and severity in patients with obstructive sleep apnea syndrome
title_short	Circulating sTweak is associated with visceral adiposity and severity in patients with obstructive sleep apnea syndrome
title_full	Circulating sTweak is associated with visceral adiposity and severity in patients with obstructive sleep apnea syndrome
title_fullStr	Circulating sTweak is associated with visceral adiposity and severity in patients with obstructive sleep apnea syndrome
title_full_unstemmed	Circulating sTweak is associated with visceral adiposity and severity in patients with obstructive sleep apnea syndrome
title_sort	circulating stweak is associated with visceral adiposity and severity in patients with obstructive sleep apnea syndrome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/934ff3441a494333b0bcd55fa2029fb1
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Circulating sTweak is associated with visceral adiposity and severity in patients with obstructive sleep apnea syndrome

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