Development of bifunctional organocatalysts and application to asymmetric total synthesis of naucleofficine I and II

Natural products often contain complex N-fused polycyclic structures with multiple substituents and stereocentres. Here, the authors developed a bifunctional organocatalyst that is instrumental in obtaining such structures and applied it to the total synthesis of naucleofficine I and II in 6 steps.

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Autores principales:	Yong-Hai Yuan, Xue Han, Fu-Ping Zhu, Jin-Miao Tian, Fu-Min Zhang, Xiao-Ming Zhang, Yong-Qiang Tu, Shao-Hua Wang, Xiang Guo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/935061a9dba6497a94cd67bf926fb828
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spelling	oai:doaj.org-article:935061a9dba6497a94cd67bf926fb8282021-12-02T15:35:51ZDevelopment of bifunctional organocatalysts and application to asymmetric total synthesis of naucleofficine I and II10.1038/s41467-019-11382-82041-1723https://doaj.org/article/935061a9dba6497a94cd67bf926fb8282019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11382-8https://doaj.org/toc/2041-1723Natural products often contain complex N-fused polycyclic structures with multiple substituents and stereocentres. Here, the authors developed a bifunctional organocatalyst that is instrumental in obtaining such structures and applied it to the total synthesis of naucleofficine I and II in 6 steps.Yong-Hai YuanXue HanFu-Ping ZhuJin-Miao TianFu-Min ZhangXiao-Ming ZhangYong-Qiang TuShao-Hua WangXiang GuoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yong-Hai Yuan Xue Han Fu-Ping Zhu Jin-Miao Tian Fu-Min Zhang Xiao-Ming Zhang Yong-Qiang Tu Shao-Hua Wang Xiang Guo Development of bifunctional organocatalysts and application to asymmetric total synthesis of naucleofficine I and II
description	Natural products often contain complex N-fused polycyclic structures with multiple substituents and stereocentres. Here, the authors developed a bifunctional organocatalyst that is instrumental in obtaining such structures and applied it to the total synthesis of naucleofficine I and II in 6 steps.
format	article
author	Yong-Hai Yuan Xue Han Fu-Ping Zhu Jin-Miao Tian Fu-Min Zhang Xiao-Ming Zhang Yong-Qiang Tu Shao-Hua Wang Xiang Guo
author_facet	Yong-Hai Yuan Xue Han Fu-Ping Zhu Jin-Miao Tian Fu-Min Zhang Xiao-Ming Zhang Yong-Qiang Tu Shao-Hua Wang Xiang Guo
author_sort	Yong-Hai Yuan
title	Development of bifunctional organocatalysts and application to asymmetric total synthesis of naucleofficine I and II
title_short	Development of bifunctional organocatalysts and application to asymmetric total synthesis of naucleofficine I and II
title_full	Development of bifunctional organocatalysts and application to asymmetric total synthesis of naucleofficine I and II
title_fullStr	Development of bifunctional organocatalysts and application to asymmetric total synthesis of naucleofficine I and II
title_full_unstemmed	Development of bifunctional organocatalysts and application to asymmetric total synthesis of naucleofficine I and II
title_sort	development of bifunctional organocatalysts and application to asymmetric total synthesis of naucleofficine i and ii
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/935061a9dba6497a94cd67bf926fb828
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Development of bifunctional organocatalysts and application to asymmetric total synthesis of naucleofficine I and II

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