Multiple truncated isoforms of MAVS prevent its spontaneous aggregation in antiviral innate immune signalling

MAVS is an essential component of the pathogen-sensing machinery, and functions by forming prion-like filaments. Here the authors show that alternatively translated forms of truncated endogenous MAVS can prevent spontaneous aggregation and degradation in cells to sustain MAVS-mediated immune signall...

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Autores principales:	Nan Qi, Yuheng Shi, Rui Zhang, Wenting Zhu, Bofeng Yuan, Xiaoyan Li, Changwan Wang, Xuewu Zhang, Fajian Hou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9350f5d8c9ed4f93a2c01a52850e4272
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spelling	oai:doaj.org-article:9350f5d8c9ed4f93a2c01a52850e42722021-12-02T14:42:41ZMultiple truncated isoforms of MAVS prevent its spontaneous aggregation in antiviral innate immune signalling10.1038/ncomms156762041-1723https://doaj.org/article/9350f5d8c9ed4f93a2c01a52850e42722017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15676https://doaj.org/toc/2041-1723MAVS is an essential component of the pathogen-sensing machinery, and functions by forming prion-like filaments. Here the authors show that alternatively translated forms of truncated endogenous MAVS can prevent spontaneous aggregation and degradation in cells to sustain MAVS-mediated immune signalling.Nan QiYuheng ShiRui ZhangWenting ZhuBofeng YuanXiaoyan LiChangwan WangXuewu ZhangFajian HouNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nan Qi Yuheng Shi Rui Zhang Wenting Zhu Bofeng Yuan Xiaoyan Li Changwan Wang Xuewu Zhang Fajian Hou Multiple truncated isoforms of MAVS prevent its spontaneous aggregation in antiviral innate immune signalling
description	MAVS is an essential component of the pathogen-sensing machinery, and functions by forming prion-like filaments. Here the authors show that alternatively translated forms of truncated endogenous MAVS can prevent spontaneous aggregation and degradation in cells to sustain MAVS-mediated immune signalling.
format	article
author	Nan Qi Yuheng Shi Rui Zhang Wenting Zhu Bofeng Yuan Xiaoyan Li Changwan Wang Xuewu Zhang Fajian Hou
author_facet	Nan Qi Yuheng Shi Rui Zhang Wenting Zhu Bofeng Yuan Xiaoyan Li Changwan Wang Xuewu Zhang Fajian Hou
author_sort	Nan Qi
title	Multiple truncated isoforms of MAVS prevent its spontaneous aggregation in antiviral innate immune signalling
title_short	Multiple truncated isoforms of MAVS prevent its spontaneous aggregation in antiviral innate immune signalling
title_full	Multiple truncated isoforms of MAVS prevent its spontaneous aggregation in antiviral innate immune signalling
title_fullStr	Multiple truncated isoforms of MAVS prevent its spontaneous aggregation in antiviral innate immune signalling
title_full_unstemmed	Multiple truncated isoforms of MAVS prevent its spontaneous aggregation in antiviral innate immune signalling
title_sort	multiple truncated isoforms of mavs prevent its spontaneous aggregation in antiviral innate immune signalling
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9350f5d8c9ed4f93a2c01a52850e4272
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Multiple truncated isoforms of MAVS prevent its spontaneous aggregation in antiviral innate immune signalling

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