Multiple truncated isoforms of MAVS prevent its spontaneous aggregation in antiviral innate immune signalling

Multiple truncated isoforms of MAVS prevent its spontaneous aggregation in antiviral innate immune signalling

MAVS is an essential component of the pathogen-sensing machinery, and functions by forming prion-like filaments. Here the authors show that alternatively translated forms of truncated endogenous MAVS can prevent spontaneous aggregation and degradation in cells to sustain MAVS-mediated immune signall...

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Autores principales: Nan Qi, Yuheng Shi, Rui Zhang, Wenting Zhu, Bofeng Yuan, Xiaoyan Li, Changwan Wang, Xuewu Zhang, Fajian Hou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
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Acceso en línea:https://doaj.org/article/9350f5d8c9ed4f93a2c01a52850e4272
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