Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice

Circadian disruption is implicated in the development of different human cancers. Here the authors show that chronic circadian disruption, through continuous jet lag, only moderately affects primary tumour growth but promotes cancer-cell dissemination and metastasis in a mouse model of spontaneous m...

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Autores principales: Eva Hadadi, William Taylor, Xiao-Mei Li, Yetki Aslan, Marthe Villote, Julie Rivière, Gaelle Duvallet, Charlotte Auriau, Sandrine Dulong, Isabelle Raymond-Letron, Sylvain Provot, Annelise Bennaceur-Griscelli, Hervé Acloque
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/9351250a0e324fe7aa73022a4bbf04d5
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Sumario:Circadian disruption is implicated in the development of different human cancers. Here the authors show that chronic circadian disruption, through continuous jet lag, only moderately affects primary tumour growth but promotes cancer-cell dissemination and metastasis in a mouse model of spontaneous mammary tumorigenesis.