Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice

Circadian disruption is implicated in the development of different human cancers. Here the authors show that chronic circadian disruption, through continuous jet lag, only moderately affects primary tumour growth but promotes cancer-cell dissemination and metastasis in a mouse model of spontaneous m...

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Autores principales:	Eva Hadadi, William Taylor, Xiao-Mei Li, Yetki Aslan, Marthe Villote, Julie Rivière, Gaelle Duvallet, Charlotte Auriau, Sandrine Dulong, Isabelle Raymond-Letron, Sylvain Provot, Annelise Bennaceur-Griscelli, Hervé Acloque
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9351250a0e324fe7aa73022a4bbf04d5
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spelling	oai:doaj.org-article:9351250a0e324fe7aa73022a4bbf04d52021-12-02T17:14:28ZChronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice10.1038/s41467-020-16890-62041-1723https://doaj.org/article/9351250a0e324fe7aa73022a4bbf04d52020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16890-6https://doaj.org/toc/2041-1723Circadian disruption is implicated in the development of different human cancers. Here the authors show that chronic circadian disruption, through continuous jet lag, only moderately affects primary tumour growth but promotes cancer-cell dissemination and metastasis in a mouse model of spontaneous mammary tumorigenesis.Eva HadadiWilliam TaylorXiao-Mei LiYetki AslanMarthe VilloteJulie RivièreGaelle DuvalletCharlotte AuriauSandrine DulongIsabelle Raymond-LetronSylvain ProvotAnnelise Bennaceur-GriscelliHervé AcloqueNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eva Hadadi William Taylor Xiao-Mei Li Yetki Aslan Marthe Villote Julie Rivière Gaelle Duvallet Charlotte Auriau Sandrine Dulong Isabelle Raymond-Letron Sylvain Provot Annelise Bennaceur-Griscelli Hervé Acloque Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice
description	Circadian disruption is implicated in the development of different human cancers. Here the authors show that chronic circadian disruption, through continuous jet lag, only moderately affects primary tumour growth but promotes cancer-cell dissemination and metastasis in a mouse model of spontaneous mammary tumorigenesis.
format	article
author	Eva Hadadi William Taylor Xiao-Mei Li Yetki Aslan Marthe Villote Julie Rivière Gaelle Duvallet Charlotte Auriau Sandrine Dulong Isabelle Raymond-Letron Sylvain Provot Annelise Bennaceur-Griscelli Hervé Acloque
author_facet	Eva Hadadi William Taylor Xiao-Mei Li Yetki Aslan Marthe Villote Julie Rivière Gaelle Duvallet Charlotte Auriau Sandrine Dulong Isabelle Raymond-Letron Sylvain Provot Annelise Bennaceur-Griscelli Hervé Acloque
author_sort	Eva Hadadi
title	Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice
title_short	Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice
title_full	Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice
title_fullStr	Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice
title_full_unstemmed	Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice
title_sort	chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9351250a0e324fe7aa73022a4bbf04d5
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Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice

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