HNF4A defines tissue-specific circadian rhythms by beaconing BMAL1::CLOCK chromatin binding and shaping the rhythmic chromatin landscape

HNF4A defines tissue-specific circadian rhythms by beaconing BMAL1::CLOCK chromatin binding and shaping the rhythmic chromatin landscape

Genome-wide occupancy of the master circadian clock transcription factor BMAL1::CLOCK varies across tissues and is reprogrammed in cancers, but how specificity is governed is not known. Here the authors show BMAL1::CLOCK in liver tissue is guided by chromatin accessibility remodeled by HNF4A, sheddi...

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Autores principales: Meng Qu, Han Qu, Zhenyu Jia, Steve A. Kay
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/9351f381b1d64b199cec3a258dc859b6
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spelling oai:doaj.org-article:9351f381b1d64b199cec3a258dc859b62021-11-08T11:11:55ZHNF4A defines tissue-specific circadian rhythms by beaconing BMAL1::CLOCK chromatin binding and shaping the rhythmic chromatin landscape10.1038/s41467-021-26567-32041-1723https://doaj.org/article/9351f381b1d64b199cec3a258dc859b62021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26567-3https://doaj.org/toc/2041-1723Genome-wide occupancy of the master circadian clock transcription factor BMAL1::CLOCK varies across tissues and is reprogrammed in cancers, but how specificity is governed is not known. Here the authors show BMAL1::CLOCK in liver tissue is guided by chromatin accessibility remodeled by HNF4A, shedding new lights onto mechanisms of dysregulated circadian rhythms in hepatocarcinoma.Meng QuHan QuZhenyu JiaSteve A. KayNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Meng Qu
Han Qu
Zhenyu Jia
Steve A. Kay
HNF4A defines tissue-specific circadian rhythms by beaconing BMAL1::CLOCK chromatin binding and shaping the rhythmic chromatin landscape
description Genome-wide occupancy of the master circadian clock transcription factor BMAL1::CLOCK varies across tissues and is reprogrammed in cancers, but how specificity is governed is not known. Here the authors show BMAL1::CLOCK in liver tissue is guided by chromatin accessibility remodeled by HNF4A, shedding new lights onto mechanisms of dysregulated circadian rhythms in hepatocarcinoma.
format article
author Meng Qu
Han Qu
Zhenyu Jia
Steve A. Kay
author_facet Meng Qu
Han Qu
Zhenyu Jia
Steve A. Kay
author_sort Meng Qu
title HNF4A defines tissue-specific circadian rhythms by beaconing BMAL1::CLOCK chromatin binding and shaping the rhythmic chromatin landscape
title_short HNF4A defines tissue-specific circadian rhythms by beaconing BMAL1::CLOCK chromatin binding and shaping the rhythmic chromatin landscape
title_full HNF4A defines tissue-specific circadian rhythms by beaconing BMAL1::CLOCK chromatin binding and shaping the rhythmic chromatin landscape
title_fullStr HNF4A defines tissue-specific circadian rhythms by beaconing BMAL1::CLOCK chromatin binding and shaping the rhythmic chromatin landscape
title_full_unstemmed HNF4A defines tissue-specific circadian rhythms by beaconing BMAL1::CLOCK chromatin binding and shaping the rhythmic chromatin landscape
title_sort hnf4a defines tissue-specific circadian rhythms by beaconing bmal1::clock chromatin binding and shaping the rhythmic chromatin landscape
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/9351f381b1d64b199cec3a258dc859b6
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AT zhenyujia hnf4adefinestissuespecificcircadianrhythmsbybeaconingbmal1clockchromatinbindingandshapingtherhythmicchromatinlandscape
AT steveakay hnf4adefinestissuespecificcircadianrhythmsbybeaconingbmal1clockchromatinbindingandshapingtherhythmicchromatinlandscape
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