Contracting CAG/CTG repeats using the CRISPR-Cas9 nickase

The expansion of trinucleotide repeats has been linked to several neurodegenerative disorders. Here, the authors show that the CRISPR-Cas9 nuclease induces both expansions and contractions of the repeat region, whereas the nickase leads predominantly to contractions.

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Detalles Bibliográficos
Autores principales:	Cinzia Cinesi, Lorène Aeschbach, Bin Yang, Vincent Dion
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9355183cceed4deda6f6dfaa00caf26e
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spelling	oai:doaj.org-article:9355183cceed4deda6f6dfaa00caf26e2021-12-02T14:39:34ZContracting CAG/CTG repeats using the CRISPR-Cas9 nickase10.1038/ncomms132722041-1723https://doaj.org/article/9355183cceed4deda6f6dfaa00caf26e2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13272https://doaj.org/toc/2041-1723The expansion of trinucleotide repeats has been linked to several neurodegenerative disorders. Here, the authors show that the CRISPR-Cas9 nuclease induces both expansions and contractions of the repeat region, whereas the nickase leads predominantly to contractions.Cinzia CinesiLorène AeschbachBin YangVincent DionNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cinzia Cinesi Lorène Aeschbach Bin Yang Vincent Dion Contracting CAG/CTG repeats using the CRISPR-Cas9 nickase
description	The expansion of trinucleotide repeats has been linked to several neurodegenerative disorders. Here, the authors show that the CRISPR-Cas9 nuclease induces both expansions and contractions of the repeat region, whereas the nickase leads predominantly to contractions.
format	article
author	Cinzia Cinesi Lorène Aeschbach Bin Yang Vincent Dion
author_facet	Cinzia Cinesi Lorène Aeschbach Bin Yang Vincent Dion
author_sort	Cinzia Cinesi
title	Contracting CAG/CTG repeats using the CRISPR-Cas9 nickase
title_short	Contracting CAG/CTG repeats using the CRISPR-Cas9 nickase
title_full	Contracting CAG/CTG repeats using the CRISPR-Cas9 nickase
title_fullStr	Contracting CAG/CTG repeats using the CRISPR-Cas9 nickase
title_full_unstemmed	Contracting CAG/CTG repeats using the CRISPR-Cas9 nickase
title_sort	contracting cag/ctg repeats using the crispr-cas9 nickase
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/9355183cceed4deda6f6dfaa00caf26e
work_keys_str_mv	AT cinziacinesi contractingcagctgrepeatsusingthecrisprcas9nickase AT loreneaeschbach contractingcagctgrepeatsusingthecrisprcas9nickase AT binyang contractingcagctgrepeatsusingthecrisprcas9nickase AT vincentdion contractingcagctgrepeatsusingthecrisprcas9nickase
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Contracting CAG/CTG repeats using the CRISPR-Cas9 nickase

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