Contracting CAG/CTG repeats using the CRISPR-Cas9 nickase

Contracting CAG/CTG repeats using the CRISPR-Cas9 nickase

The expansion of trinucleotide repeats has been linked to several neurodegenerative disorders. Here, the authors show that the CRISPR-Cas9 nuclease induces both expansions and contractions of the repeat region, whereas the nickase leads predominantly to contractions.

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Detalles Bibliográficos
Autores principales: Cinzia Cinesi, Lorène Aeschbach, Bin Yang, Vincent Dion
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/9355183cceed4deda6f6dfaa00caf26e
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