Comparative pathogenomics reveals horizontally acquired novel virulence genes in fungi infecting cereal hosts.

Comparative analyses of pathogen genomes provide new insights into how pathogens have evolved common and divergent virulence strategies to invade related plant species. Fusarium crown and root rots are important diseases of wheat and barley world-wide. In Australia, these diseases are primarily caus...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Donald M Gardiner, Megan C McDonald, Lorenzo Covarelli, Peter S Solomon, Anca G Rusu, Mhairi Marshall, Kemal Kazan, Sukumar Chakraborty, Bruce A McDonald, John M Manners
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/935bb53cbd9b406f8cdddb7ed75035ac
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:935bb53cbd9b406f8cdddb7ed75035ac
record_format	dspace
spelling	oai:doaj.org-article:935bb53cbd9b406f8cdddb7ed75035ac2021-11-18T06:03:54ZComparative pathogenomics reveals horizontally acquired novel virulence genes in fungi infecting cereal hosts.1553-73661553-737410.1371/journal.ppat.1002952https://doaj.org/article/935bb53cbd9b406f8cdddb7ed75035ac2012-09-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23028337/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Comparative analyses of pathogen genomes provide new insights into how pathogens have evolved common and divergent virulence strategies to invade related plant species. Fusarium crown and root rots are important diseases of wheat and barley world-wide. In Australia, these diseases are primarily caused by the fungal pathogen Fusarium pseudograminearum. Comparative genomic analyses showed that the F. pseudograminearum genome encodes proteins that are present in other fungal pathogens of cereals but absent in non-cereal pathogens. In some cases, these cereal pathogen specific genes were also found in bacteria associated with plants. Phylogenetic analysis of selected F. pseudograminearum genes supported the hypothesis of horizontal gene transfer into diverse cereal pathogens. Two horizontally acquired genes with no previously known role in fungal pathogenesis were studied functionally via gene knockout methods and shown to significantly affect virulence of F. pseudograminearum on the cereal hosts wheat and barley. Our results indicate using comparative genomics to identify genes specific to pathogens of related hosts reveals novel virulence genes and illustrates the importance of horizontal gene transfer in the evolution of plant infecting fungal pathogens.Donald M GardinerMegan C McDonaldLorenzo CovarelliPeter S SolomonAnca G RusuMhairi MarshallKemal KazanSukumar ChakrabortyBruce A McDonaldJohn M MannersPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 8, Iss 9, p e1002952 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Donald M Gardiner Megan C McDonald Lorenzo Covarelli Peter S Solomon Anca G Rusu Mhairi Marshall Kemal Kazan Sukumar Chakraborty Bruce A McDonald John M Manners Comparative pathogenomics reveals horizontally acquired novel virulence genes in fungi infecting cereal hosts.
description	Comparative analyses of pathogen genomes provide new insights into how pathogens have evolved common and divergent virulence strategies to invade related plant species. Fusarium crown and root rots are important diseases of wheat and barley world-wide. In Australia, these diseases are primarily caused by the fungal pathogen Fusarium pseudograminearum. Comparative genomic analyses showed that the F. pseudograminearum genome encodes proteins that are present in other fungal pathogens of cereals but absent in non-cereal pathogens. In some cases, these cereal pathogen specific genes were also found in bacteria associated with plants. Phylogenetic analysis of selected F. pseudograminearum genes supported the hypothesis of horizontal gene transfer into diverse cereal pathogens. Two horizontally acquired genes with no previously known role in fungal pathogenesis were studied functionally via gene knockout methods and shown to significantly affect virulence of F. pseudograminearum on the cereal hosts wheat and barley. Our results indicate using comparative genomics to identify genes specific to pathogens of related hosts reveals novel virulence genes and illustrates the importance of horizontal gene transfer in the evolution of plant infecting fungal pathogens.
format	article
author	Donald M Gardiner Megan C McDonald Lorenzo Covarelli Peter S Solomon Anca G Rusu Mhairi Marshall Kemal Kazan Sukumar Chakraborty Bruce A McDonald John M Manners
author_facet	Donald M Gardiner Megan C McDonald Lorenzo Covarelli Peter S Solomon Anca G Rusu Mhairi Marshall Kemal Kazan Sukumar Chakraborty Bruce A McDonald John M Manners
author_sort	Donald M Gardiner
title	Comparative pathogenomics reveals horizontally acquired novel virulence genes in fungi infecting cereal hosts.
title_short	Comparative pathogenomics reveals horizontally acquired novel virulence genes in fungi infecting cereal hosts.
title_full	Comparative pathogenomics reveals horizontally acquired novel virulence genes in fungi infecting cereal hosts.
title_fullStr	Comparative pathogenomics reveals horizontally acquired novel virulence genes in fungi infecting cereal hosts.
title_full_unstemmed	Comparative pathogenomics reveals horizontally acquired novel virulence genes in fungi infecting cereal hosts.
title_sort	comparative pathogenomics reveals horizontally acquired novel virulence genes in fungi infecting cereal hosts.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/935bb53cbd9b406f8cdddb7ed75035ac
work_keys_str_mv	AT donaldmgardiner comparativepathogenomicsrevealshorizontallyacquirednovelvirulencegenesinfungiinfectingcerealhosts AT megancmcdonald comparativepathogenomicsrevealshorizontallyacquirednovelvirulencegenesinfungiinfectingcerealhosts AT lorenzocovarelli comparativepathogenomicsrevealshorizontallyacquirednovelvirulencegenesinfungiinfectingcerealhosts AT peterssolomon comparativepathogenomicsrevealshorizontallyacquirednovelvirulencegenesinfungiinfectingcerealhosts AT ancagrusu comparativepathogenomicsrevealshorizontallyacquirednovelvirulencegenesinfungiinfectingcerealhosts AT mhairimarshall comparativepathogenomicsrevealshorizontallyacquirednovelvirulencegenesinfungiinfectingcerealhosts AT kemalkazan comparativepathogenomicsrevealshorizontallyacquirednovelvirulencegenesinfungiinfectingcerealhosts AT sukumarchakraborty comparativepathogenomicsrevealshorizontallyacquirednovelvirulencegenesinfungiinfectingcerealhosts AT bruceamcdonald comparativepathogenomicsrevealshorizontallyacquirednovelvirulencegenesinfungiinfectingcerealhosts AT johnmmanners comparativepathogenomicsrevealshorizontallyacquirednovelvirulencegenesinfungiinfectingcerealhosts
_version_	1718424618153279488

Comparative pathogenomics reveals horizontally acquired novel virulence genes in fungi infecting cereal hosts.

Ejemplares similares