Selenization of S. cerevisiae increases its protective potential in experimental autoimmune encephalomyelitis by triggering an intestinal immunomodulatory loop

Abstract Multiple sclerosis is an autoimmune disease that affects the myelinated central nervous system (CNS) neurons and triggers physical and cognitive disabilities. Conventional therapy is based on disease-modifying drugs that control disease severity but can also be deleterious. Complementary me...

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Autores principales:	Thais Fernanda de Campos Fraga-Silva, Luiza Ayumi Nishiyama Mimura, Larissa Ragozo Cardoso de Oliveira, Juliana Helena dos Santos Toledo, Patrícia Aparecida Borim, Sofia Fernanda Gonçalvez Zorzella-Pezavento, Diego Peres Alonso, Paulo Eduardo Martins Ribolla, Carlos Alberto Ferreira de Oliveira, Denise Morais da Fonseca, Eduardo J. Villablanca, Alexandrina Sartori
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/935cf394cc7140d083de60231e0669d2
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spelling	oai:doaj.org-article:935cf394cc7140d083de60231e0669d22021-12-02T12:40:40ZSelenization of S. cerevisiae increases its protective potential in experimental autoimmune encephalomyelitis by triggering an intestinal immunomodulatory loop10.1038/s41598-020-79102-72045-2322https://doaj.org/article/935cf394cc7140d083de60231e0669d22020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79102-7https://doaj.org/toc/2045-2322Abstract Multiple sclerosis is an autoimmune disease that affects the myelinated central nervous system (CNS) neurons and triggers physical and cognitive disabilities. Conventional therapy is based on disease-modifying drugs that control disease severity but can also be deleterious. Complementary medicines have been adopted and evidence indicates that yeast supplements can improve symptoms mainly by modulating the immune response. In this investigation, we evaluated the therapeutic potential of Saccharomyces cerevisiae and its selenized derivative (Selemax) in experimental autoimmune encephalomyelitis (EAE). Female C57BL/6 mice submitted to EAE induction were orally supplemented with these yeasts by gavage from day 0 to day 14 after EAE induction. Both supplements determined significant reduction in clinical signs concomitantly with diminished Th1 immune response in CNS, increased proportion of Foxp3+ lymphocytes in inguinal and mesenteric lymph nodes and increased microbiota diversity. However, Selemax was more effective clinically and immunologically; it reduced disease prevalence more sharply, increased the proportion of CD103+ dendritic cells expressing high levels of PD-L1 in mesenteric lymph nodes and reduced the intestinal inflammatory process more strongly than S. cerevisiae. These results suggest a clear gut-brain axis modulation by selenized S. cerevisiae and suggest their inclusion in clinical trials.Thais Fernanda de Campos Fraga-SilvaLuiza Ayumi Nishiyama MimuraLarissa Ragozo Cardoso de OliveiraJuliana Helena dos Santos ToledoPatrícia Aparecida BorimSofia Fernanda Gonçalvez Zorzella-PezaventoDiego Peres AlonsoPaulo Eduardo Martins RibollaCarlos Alberto Ferreira de OliveiraDenise Morais da FonsecaEduardo J. VillablancaAlexandrina SartoriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Thais Fernanda de Campos Fraga-Silva Luiza Ayumi Nishiyama Mimura Larissa Ragozo Cardoso de Oliveira Juliana Helena dos Santos Toledo Patrícia Aparecida Borim Sofia Fernanda Gonçalvez Zorzella-Pezavento Diego Peres Alonso Paulo Eduardo Martins Ribolla Carlos Alberto Ferreira de Oliveira Denise Morais da Fonseca Eduardo J. Villablanca Alexandrina Sartori Selenization of S. cerevisiae increases its protective potential in experimental autoimmune encephalomyelitis by triggering an intestinal immunomodulatory loop
description	Abstract Multiple sclerosis is an autoimmune disease that affects the myelinated central nervous system (CNS) neurons and triggers physical and cognitive disabilities. Conventional therapy is based on disease-modifying drugs that control disease severity but can also be deleterious. Complementary medicines have been adopted and evidence indicates that yeast supplements can improve symptoms mainly by modulating the immune response. In this investigation, we evaluated the therapeutic potential of Saccharomyces cerevisiae and its selenized derivative (Selemax) in experimental autoimmune encephalomyelitis (EAE). Female C57BL/6 mice submitted to EAE induction were orally supplemented with these yeasts by gavage from day 0 to day 14 after EAE induction. Both supplements determined significant reduction in clinical signs concomitantly with diminished Th1 immune response in CNS, increased proportion of Foxp3+ lymphocytes in inguinal and mesenteric lymph nodes and increased microbiota diversity. However, Selemax was more effective clinically and immunologically; it reduced disease prevalence more sharply, increased the proportion of CD103+ dendritic cells expressing high levels of PD-L1 in mesenteric lymph nodes and reduced the intestinal inflammatory process more strongly than S. cerevisiae. These results suggest a clear gut-brain axis modulation by selenized S. cerevisiae and suggest their inclusion in clinical trials.
format	article
author	Thais Fernanda de Campos Fraga-Silva Luiza Ayumi Nishiyama Mimura Larissa Ragozo Cardoso de Oliveira Juliana Helena dos Santos Toledo Patrícia Aparecida Borim Sofia Fernanda Gonçalvez Zorzella-Pezavento Diego Peres Alonso Paulo Eduardo Martins Ribolla Carlos Alberto Ferreira de Oliveira Denise Morais da Fonseca Eduardo J. Villablanca Alexandrina Sartori
author_facet	Thais Fernanda de Campos Fraga-Silva Luiza Ayumi Nishiyama Mimura Larissa Ragozo Cardoso de Oliveira Juliana Helena dos Santos Toledo Patrícia Aparecida Borim Sofia Fernanda Gonçalvez Zorzella-Pezavento Diego Peres Alonso Paulo Eduardo Martins Ribolla Carlos Alberto Ferreira de Oliveira Denise Morais da Fonseca Eduardo J. Villablanca Alexandrina Sartori
author_sort	Thais Fernanda de Campos Fraga-Silva
title	Selenization of S. cerevisiae increases its protective potential in experimental autoimmune encephalomyelitis by triggering an intestinal immunomodulatory loop
title_short	Selenization of S. cerevisiae increases its protective potential in experimental autoimmune encephalomyelitis by triggering an intestinal immunomodulatory loop
title_full	Selenization of S. cerevisiae increases its protective potential in experimental autoimmune encephalomyelitis by triggering an intestinal immunomodulatory loop
title_fullStr	Selenization of S. cerevisiae increases its protective potential in experimental autoimmune encephalomyelitis by triggering an intestinal immunomodulatory loop
title_full_unstemmed	Selenization of S. cerevisiae increases its protective potential in experimental autoimmune encephalomyelitis by triggering an intestinal immunomodulatory loop
title_sort	selenization of s. cerevisiae increases its protective potential in experimental autoimmune encephalomyelitis by triggering an intestinal immunomodulatory loop
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/935cf394cc7140d083de60231e0669d2
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Selenization of S. cerevisiae increases its protective potential in experimental autoimmune encephalomyelitis by triggering an intestinal immunomodulatory loop

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