Biophysical ambiguities prevent accurate genetic prediction

In quantitative genetics, it is widely assumed that mutations combine additively or epistasis can be predicted with statistical or mechanistic models. Here, the authors use the phage lambda repressor model to show how biophysical ambiguity and non-monotonic functions confound phenotypic prediction.

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Detalles Bibliográficos
Autores principales:	Xianghua Li, Ben Lehner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9363fca2457244e3902b305d10ca9308
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id	oai:doaj.org-article:9363fca2457244e3902b305d10ca9308
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spelling	oai:doaj.org-article:9363fca2457244e3902b305d10ca93082021-12-02T17:18:08ZBiophysical ambiguities prevent accurate genetic prediction10.1038/s41467-020-18694-02041-1723https://doaj.org/article/9363fca2457244e3902b305d10ca93082020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18694-0https://doaj.org/toc/2041-1723In quantitative genetics, it is widely assumed that mutations combine additively or epistasis can be predicted with statistical or mechanistic models. Here, the authors use the phage lambda repressor model to show how biophysical ambiguity and non-monotonic functions confound phenotypic prediction.Xianghua LiBen LehnerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xianghua Li Ben Lehner Biophysical ambiguities prevent accurate genetic prediction
description	In quantitative genetics, it is widely assumed that mutations combine additively or epistasis can be predicted with statistical or mechanistic models. Here, the authors use the phage lambda repressor model to show how biophysical ambiguity and non-monotonic functions confound phenotypic prediction.
format	article
author	Xianghua Li Ben Lehner
author_facet	Xianghua Li Ben Lehner
author_sort	Xianghua Li
title	Biophysical ambiguities prevent accurate genetic prediction
title_short	Biophysical ambiguities prevent accurate genetic prediction
title_full	Biophysical ambiguities prevent accurate genetic prediction
title_fullStr	Biophysical ambiguities prevent accurate genetic prediction
title_full_unstemmed	Biophysical ambiguities prevent accurate genetic prediction
title_sort	biophysical ambiguities prevent accurate genetic prediction
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9363fca2457244e3902b305d10ca9308
work_keys_str_mv	AT xianghuali biophysicalambiguitiespreventaccurategeneticprediction AT benlehner biophysicalambiguitiespreventaccurategeneticprediction
_version_	1718381158341804032

Biophysical ambiguities prevent accurate genetic prediction

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