Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms

Early-life stress primes depression in adulthood. This study shows that early maternal separation leads to lateral habenula (LHb) hyperactivity and causes depressive-like phenotypes, the latter being reversible when LHb hyperactivity is reduced chemogenetically or through deep-brain stimulation.

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Detalles Bibliográficos
Autores principales: Anna Tchenio, Salvatore Lecca, Kristina Valentinova, Manuel Mameli
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/936450413b8840da904071ec58df9446
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Descripción
Sumario:Early-life stress primes depression in adulthood. This study shows that early maternal separation leads to lateral habenula (LHb) hyperactivity and causes depressive-like phenotypes, the latter being reversible when LHb hyperactivity is reduced chemogenetically or through deep-brain stimulation.