Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms

Early-life stress primes depression in adulthood. This study shows that early maternal separation leads to lateral habenula (LHb) hyperactivity and causes depressive-like phenotypes, the latter being reversible when LHb hyperactivity is reduced chemogenetically or through deep-brain stimulation.

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Detalles Bibliográficos
Autores principales:	Anna Tchenio, Salvatore Lecca, Kristina Valentinova, Manuel Mameli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/936450413b8840da904071ec58df9446
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spelling	oai:doaj.org-article:936450413b8840da904071ec58df94462021-12-02T14:40:26ZLimiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms10.1038/s41467-017-01192-12041-1723https://doaj.org/article/936450413b8840da904071ec58df94462017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01192-1https://doaj.org/toc/2041-1723Early-life stress primes depression in adulthood. This study shows that early maternal separation leads to lateral habenula (LHb) hyperactivity and causes depressive-like phenotypes, the latter being reversible when LHb hyperactivity is reduced chemogenetically or through deep-brain stimulation.Anna TchenioSalvatore LeccaKristina ValentinovaManuel MameliNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anna Tchenio Salvatore Lecca Kristina Valentinova Manuel Mameli Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms
description	Early-life stress primes depression in adulthood. This study shows that early maternal separation leads to lateral habenula (LHb) hyperactivity and causes depressive-like phenotypes, the latter being reversible when LHb hyperactivity is reduced chemogenetically or through deep-brain stimulation.
format	article
author	Anna Tchenio Salvatore Lecca Kristina Valentinova Manuel Mameli
author_facet	Anna Tchenio Salvatore Lecca Kristina Valentinova Manuel Mameli
author_sort	Anna Tchenio
title	Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms
title_short	Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms
title_full	Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms
title_fullStr	Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms
title_full_unstemmed	Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms
title_sort	limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/936450413b8840da904071ec58df9446
work_keys_str_mv	AT annatchenio limitinghabenularhyperactivityamelioratesmaternalseparationdrivendepressivelikesymptoms AT salvatorelecca limitinghabenularhyperactivityamelioratesmaternalseparationdrivendepressivelikesymptoms AT kristinavalentinova limitinghabenularhyperactivityamelioratesmaternalseparationdrivendepressivelikesymptoms AT manuelmameli limitinghabenularhyperactivityamelioratesmaternalseparationdrivendepressivelikesymptoms
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Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms

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