A Minimally Invasive Method for the Treatment of Post-Traumatic Disorders of the Bone Union of the Tibia

Background. The ability to control regeneration processes is a key link in the development of methods for treating patients with post-traumatic disorders of reparative osteogenesis. Aim of the study. To evaluate the effectiveness of the fusion of the tibia by local application of the interferon-beta...

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Autores principales:	V. F. Lebedev, L. A. Dmitriyeva, I. A. Shuruguna, P. N. Khaziyev
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2020
Materias:	reparative osteogenesis delayed consolidation pseudarthrosis bone marrow interferon-beta Science Q
Acceso en línea:	https://doaj.org/article/936615c8336943538dd7589aceaa3963
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spelling	oai:doaj.org-article:936615c8336943538dd7589aceaa39632021-11-23T06:14:45ZA Minimally Invasive Method for the Treatment of Post-Traumatic Disorders of the Bone Union of the Tibia2541-94202587-959610.29413/ABS.2020-5.5.14https://doaj.org/article/936615c8336943538dd7589aceaa39632020-11-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2448https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. The ability to control regeneration processes is a key link in the development of methods for treating patients with post-traumatic disorders of reparative osteogenesis. Aim of the study. To evaluate the effectiveness of the fusion of the tibia by local application of the interferon-beta preparation with autogenous bone marrow punctate in post-traumatic disorders of reparative regeneration.Material and methods. The analysis of the effectiveness of clinical application of autogenous bone marrow with interferon-beta-1b in 64 patients with delayed consolidation and pseudarthrosis of the tibia was carried out. All patients underwent external bone fixation. In order to optimize reparative osteogenesis during the operation, a mixture containing 3–4 ml of bone marrow with 8 million IU/0.5 ml of interferon beta-1b solution was injected locally into the interfragmental space.Results. With puncture local injection of interferon-beta with punctate of autogenous bone marrow with delayed consolidation, fusion of the tibial fracture was achieved in 100 % of cases. In patients with a diagnosis of a pseudarthrosis of the tibia, a positive result was achieved in 90.3 % of cases. Thus, the local application of autogenous bone marrow together with the interferon-beta preparation made it possible to achieve bone fusion in post-traumatic disorders of bone regeneration in 95.2 % of cases.Conclusion. With delayed consolidation and developing hypertrophic pseudoarthrosis in conditions of stable fixation with anatomical reposition of fragments, puncture autotransplantation of a mixture of bone marrow with a solution of interferon-beta is proposed.V. F. LebedevL. A. DmitriyevaI. A. ShurugunaP. N. KhaziyevScientific Сentre for Family Health and Human Reproduction Problemsarticlereparative osteogenesisdelayed consolidationpseudarthrosisbone marrowinterferon-betaScienceQRUActa Biomedica Scientifica, Vol 5, Iss 5, Pp 107-111 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	reparative osteogenesis delayed consolidation pseudarthrosis bone marrow interferon-beta Science Q
spellingShingle	reparative osteogenesis delayed consolidation pseudarthrosis bone marrow interferon-beta Science Q V. F. Lebedev L. A. Dmitriyeva I. A. Shuruguna P. N. Khaziyev A Minimally Invasive Method for the Treatment of Post-Traumatic Disorders of the Bone Union of the Tibia
description	Background. The ability to control regeneration processes is a key link in the development of methods for treating patients with post-traumatic disorders of reparative osteogenesis. Aim of the study. To evaluate the effectiveness of the fusion of the tibia by local application of the interferon-beta preparation with autogenous bone marrow punctate in post-traumatic disorders of reparative regeneration.Material and methods. The analysis of the effectiveness of clinical application of autogenous bone marrow with interferon-beta-1b in 64 patients with delayed consolidation and pseudarthrosis of the tibia was carried out. All patients underwent external bone fixation. In order to optimize reparative osteogenesis during the operation, a mixture containing 3–4 ml of bone marrow with 8 million IU/0.5 ml of interferon beta-1b solution was injected locally into the interfragmental space.Results. With puncture local injection of interferon-beta with punctate of autogenous bone marrow with delayed consolidation, fusion of the tibial fracture was achieved in 100 % of cases. In patients with a diagnosis of a pseudarthrosis of the tibia, a positive result was achieved in 90.3 % of cases. Thus, the local application of autogenous bone marrow together with the interferon-beta preparation made it possible to achieve bone fusion in post-traumatic disorders of bone regeneration in 95.2 % of cases.Conclusion. With delayed consolidation and developing hypertrophic pseudoarthrosis in conditions of stable fixation with anatomical reposition of fragments, puncture autotransplantation of a mixture of bone marrow with a solution of interferon-beta is proposed.
format	article
author	V. F. Lebedev L. A. Dmitriyeva I. A. Shuruguna P. N. Khaziyev
author_facet	V. F. Lebedev L. A. Dmitriyeva I. A. Shuruguna P. N. Khaziyev
author_sort	V. F. Lebedev
title	A Minimally Invasive Method for the Treatment of Post-Traumatic Disorders of the Bone Union of the Tibia
title_short	A Minimally Invasive Method for the Treatment of Post-Traumatic Disorders of the Bone Union of the Tibia
title_full	A Minimally Invasive Method for the Treatment of Post-Traumatic Disorders of the Bone Union of the Tibia
title_fullStr	A Minimally Invasive Method for the Treatment of Post-Traumatic Disorders of the Bone Union of the Tibia
title_full_unstemmed	A Minimally Invasive Method for the Treatment of Post-Traumatic Disorders of the Bone Union of the Tibia
title_sort	minimally invasive method for the treatment of post-traumatic disorders of the bone union of the tibia
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2020
url	https://doaj.org/article/936615c8336943538dd7589aceaa3963
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A Minimally Invasive Method for the Treatment of Post-Traumatic Disorders of the Bone Union of the Tibia

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