Generation of App knock-in mice reveals deletion mutations protective against Alzheimer’s disease-like pathology

To date, only one mutation in the gene for amyloid-beta precursor protein APP has been suggested to be protective against Alzheimer’s disease. Here, authors found using gene editing of a mutant App knock-in mouse line that deletion of the 3’UTR region is protective against amyloid-β accumulation in...

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Autores principales:	Kenichi Nagata, Mika Takahashi, Yukio Matsuba, Fumi Okuyama-Uchimura, Kaori Sato, Shoko Hashimoto, Takashi Saito, Takaomi C. Saido
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9369258369b44894ba9ece547f3cc7ff
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spelling	oai:doaj.org-article:9369258369b44894ba9ece547f3cc7ff2021-12-02T17:31:44ZGeneration of App knock-in mice reveals deletion mutations protective against Alzheimer’s disease-like pathology10.1038/s41467-018-04238-02041-1723https://doaj.org/article/9369258369b44894ba9ece547f3cc7ff2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04238-0https://doaj.org/toc/2041-1723To date, only one mutation in the gene for amyloid-beta precursor protein APP has been suggested to be protective against Alzheimer’s disease. Here, authors found using gene editing of a mutant App knock-in mouse line that deletion of the 3’UTR region is protective against amyloid-β accumulation in vivo, and subsequently identify a 52-bp element in the 3’UTR region that is responsible for this effect.Kenichi NagataMika TakahashiYukio MatsubaFumi Okuyama-UchimuraKaori SatoShoko HashimotoTakashi SaitoTakaomi C. SaidoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kenichi Nagata Mika Takahashi Yukio Matsuba Fumi Okuyama-Uchimura Kaori Sato Shoko Hashimoto Takashi Saito Takaomi C. Saido Generation of App knock-in mice reveals deletion mutations protective against Alzheimer’s disease-like pathology
description	To date, only one mutation in the gene for amyloid-beta precursor protein APP has been suggested to be protective against Alzheimer’s disease. Here, authors found using gene editing of a mutant App knock-in mouse line that deletion of the 3’UTR region is protective against amyloid-β accumulation in vivo, and subsequently identify a 52-bp element in the 3’UTR region that is responsible for this effect.
format	article
author	Kenichi Nagata Mika Takahashi Yukio Matsuba Fumi Okuyama-Uchimura Kaori Sato Shoko Hashimoto Takashi Saito Takaomi C. Saido
author_facet	Kenichi Nagata Mika Takahashi Yukio Matsuba Fumi Okuyama-Uchimura Kaori Sato Shoko Hashimoto Takashi Saito Takaomi C. Saido
author_sort	Kenichi Nagata
title	Generation of App knock-in mice reveals deletion mutations protective against Alzheimer’s disease-like pathology
title_short	Generation of App knock-in mice reveals deletion mutations protective against Alzheimer’s disease-like pathology
title_full	Generation of App knock-in mice reveals deletion mutations protective against Alzheimer’s disease-like pathology
title_fullStr	Generation of App knock-in mice reveals deletion mutations protective against Alzheimer’s disease-like pathology
title_full_unstemmed	Generation of App knock-in mice reveals deletion mutations protective against Alzheimer’s disease-like pathology
title_sort	generation of app knock-in mice reveals deletion mutations protective against alzheimer’s disease-like pathology
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9369258369b44894ba9ece547f3cc7ff
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Generation of App knock-in mice reveals deletion mutations protective against Alzheimer’s disease-like pathology

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