Optimized procedures for testing plasma metanephrines in patients on hemodialysis

Abstract Diagnosis of pheochromocytomas and paragangliomas in patients receiving hemodialysis is troublesome. The aim of the study was to establish optimal conditions for blood sampling for mass spectrometric measurements of normetanephrine, metanephrine and 3-methoxytyramine in patients on hemodial...

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Autores principales:	Christina Pamporaki, Aleksander Prejbisz, Robert Małecki, Frank Pistrosch, Mirko Peitzsch, Steffen Bishoff, Petra Mueller, Iris Meyer, Doreen Reimann, Katarzyna Hanus, Andrzej Januszewicz, Stefan R. Bornstein, Simon Parmentier, Carola Kunath, Jacques W. M. Lenders, Graeme Eisenhofer, Jens Passauer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/936a1adbdf8940cd84fcef713e6b9474
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spelling	oai:doaj.org-article:936a1adbdf8940cd84fcef713e6b94742021-12-02T16:17:34ZOptimized procedures for testing plasma metanephrines in patients on hemodialysis10.1038/s41598-021-94104-92045-2322https://doaj.org/article/936a1adbdf8940cd84fcef713e6b94742021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94104-9https://doaj.org/toc/2045-2322Abstract Diagnosis of pheochromocytomas and paragangliomas in patients receiving hemodialysis is troublesome. The aim of the study was to establish optimal conditions for blood sampling for mass spectrometric measurements of normetanephrine, metanephrine and 3-methoxytyramine in patients on hemodialysis and specific reference intervals for plasma metanephrines under the most optimal sampling conditions. Blood was sampled before and near the end of dialysis, including different sampling sites in 170 patients on hemodialysis. Plasma normetanephrine concentrations were lower (P < 0.0001) and metanephrine concentrations higher (P < 0.0001) in shunt than in venous blood, with no differences for 3-methoxytyramine. Normetanephrine, metanephrine and 3-methoxytyramine concentrations in shunt and venous blood were lower (P < 0.0001) near the end than before hemodialysis. Upper cut-offs for normetanephrine were 34% lower when the blood was drawn from the shunt and near the end of hemodialysis compared to blood drawn before hemodialysis. This study establishes optimal sampling conditions using blood from the dialysis shunt near the end of hemodialysis with optimal reference intervals for plasma metanephrines for the diagnosis of pheochromocytomas/paragangliomas among patients on hemodialysis.Christina PamporakiAleksander PrejbiszRobert MałeckiFrank PistroschMirko PeitzschSteffen BishoffPetra MuellerIris MeyerDoreen ReimannKatarzyna HanusAndrzej JanuszewiczStefan R. BornsteinSimon ParmentierCarola KunathJacques W. M. LendersGraeme EisenhoferJens PassauerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christina Pamporaki Aleksander Prejbisz Robert Małecki Frank Pistrosch Mirko Peitzsch Steffen Bishoff Petra Mueller Iris Meyer Doreen Reimann Katarzyna Hanus Andrzej Januszewicz Stefan R. Bornstein Simon Parmentier Carola Kunath Jacques W. M. Lenders Graeme Eisenhofer Jens Passauer Optimized procedures for testing plasma metanephrines in patients on hemodialysis
description	Abstract Diagnosis of pheochromocytomas and paragangliomas in patients receiving hemodialysis is troublesome. The aim of the study was to establish optimal conditions for blood sampling for mass spectrometric measurements of normetanephrine, metanephrine and 3-methoxytyramine in patients on hemodialysis and specific reference intervals for plasma metanephrines under the most optimal sampling conditions. Blood was sampled before and near the end of dialysis, including different sampling sites in 170 patients on hemodialysis. Plasma normetanephrine concentrations were lower (P < 0.0001) and metanephrine concentrations higher (P < 0.0001) in shunt than in venous blood, with no differences for 3-methoxytyramine. Normetanephrine, metanephrine and 3-methoxytyramine concentrations in shunt and venous blood were lower (P < 0.0001) near the end than before hemodialysis. Upper cut-offs for normetanephrine were 34% lower when the blood was drawn from the shunt and near the end of hemodialysis compared to blood drawn before hemodialysis. This study establishes optimal sampling conditions using blood from the dialysis shunt near the end of hemodialysis with optimal reference intervals for plasma metanephrines for the diagnosis of pheochromocytomas/paragangliomas among patients on hemodialysis.
format	article
author	Christina Pamporaki Aleksander Prejbisz Robert Małecki Frank Pistrosch Mirko Peitzsch Steffen Bishoff Petra Mueller Iris Meyer Doreen Reimann Katarzyna Hanus Andrzej Januszewicz Stefan R. Bornstein Simon Parmentier Carola Kunath Jacques W. M. Lenders Graeme Eisenhofer Jens Passauer
author_facet	Christina Pamporaki Aleksander Prejbisz Robert Małecki Frank Pistrosch Mirko Peitzsch Steffen Bishoff Petra Mueller Iris Meyer Doreen Reimann Katarzyna Hanus Andrzej Januszewicz Stefan R. Bornstein Simon Parmentier Carola Kunath Jacques W. M. Lenders Graeme Eisenhofer Jens Passauer
author_sort	Christina Pamporaki
title	Optimized procedures for testing plasma metanephrines in patients on hemodialysis
title_short	Optimized procedures for testing plasma metanephrines in patients on hemodialysis
title_full	Optimized procedures for testing plasma metanephrines in patients on hemodialysis
title_fullStr	Optimized procedures for testing plasma metanephrines in patients on hemodialysis
title_full_unstemmed	Optimized procedures for testing plasma metanephrines in patients on hemodialysis
title_sort	optimized procedures for testing plasma metanephrines in patients on hemodialysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/936a1adbdf8940cd84fcef713e6b9474
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Optimized procedures for testing plasma metanephrines in patients on hemodialysis

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