Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes

Efforts to determine the effects of drugs on epithelial barriers could benefit from better in vitro models. Here the authors develop a microfluidic device supporting the growth and function of extracellular matrix-supported intestinal tubules, and evaluate the effect of staurosporine and acetylsalic...

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Autores principales:	Sebastiaan J. Trietsch, Elena Naumovska, Dorota Kurek, Meily C. Setyawati, Marianne K. Vormann, Karlijn J. Wilschut, Henriëtte L. Lanz, Arnaud Nicolas, Chee Ping Ng, Jos Joore, Stefan Kustermann, Adrian Roth, Thomas Hankemeier, Annie Moisan, Paul Vulto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/936a946cd151424cbb470b23c064cef4
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spelling	oai:doaj.org-article:936a946cd151424cbb470b23c064cef42021-12-02T13:57:44ZMembrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes10.1038/s41467-017-00259-32041-1723https://doaj.org/article/936a946cd151424cbb470b23c064cef42017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00259-3https://doaj.org/toc/2041-1723Efforts to determine the effects of drugs on epithelial barriers could benefit from better in vitro models. Here the authors develop a microfluidic device supporting the growth and function of extracellular matrix-supported intestinal tubules, and evaluate the effect of staurosporine and acetylsalicylic acid on barrier integrity.Sebastiaan J. TrietschElena NaumovskaDorota KurekMeily C. SetyawatiMarianne K. VormannKarlijn J. WilschutHenriëtte L. LanzArnaud NicolasChee Ping NgJos JooreStefan KustermannAdrian RothThomas HankemeierAnnie MoisanPaul VultoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sebastiaan J. Trietsch Elena Naumovska Dorota Kurek Meily C. Setyawati Marianne K. Vormann Karlijn J. Wilschut Henriëtte L. Lanz Arnaud Nicolas Chee Ping Ng Jos Joore Stefan Kustermann Adrian Roth Thomas Hankemeier Annie Moisan Paul Vulto Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes
description	Efforts to determine the effects of drugs on epithelial barriers could benefit from better in vitro models. Here the authors develop a microfluidic device supporting the growth and function of extracellular matrix-supported intestinal tubules, and evaluate the effect of staurosporine and acetylsalicylic acid on barrier integrity.
format	article
author	Sebastiaan J. Trietsch Elena Naumovska Dorota Kurek Meily C. Setyawati Marianne K. Vormann Karlijn J. Wilschut Henriëtte L. Lanz Arnaud Nicolas Chee Ping Ng Jos Joore Stefan Kustermann Adrian Roth Thomas Hankemeier Annie Moisan Paul Vulto
author_facet	Sebastiaan J. Trietsch Elena Naumovska Dorota Kurek Meily C. Setyawati Marianne K. Vormann Karlijn J. Wilschut Henriëtte L. Lanz Arnaud Nicolas Chee Ping Ng Jos Joore Stefan Kustermann Adrian Roth Thomas Hankemeier Annie Moisan Paul Vulto
author_sort	Sebastiaan J. Trietsch
title	Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes
title_short	Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes
title_full	Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes
title_fullStr	Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes
title_full_unstemmed	Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes
title_sort	membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/936a946cd151424cbb470b23c064cef4
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Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes

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