The role of surfactants in the formulation of elastic liposomal gels containing a synthetic opioid analgesic

Sima Singh,1,* Harsh Vardhan,1,* Niranjan G Kotla,2 Balaji Maddiboyina,3 Dinesh Sharma,4 Thomas J Webster5,6 1School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, India; 2Center for Research in Medical Devices, National University of Ireland, Galway, Ireland; 3Department of...

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Autores principales:	Singh S, Vardhan H, Kotla NG, Maddiboyina B, Sharma D, Webster TJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	elastic liposome skin delivery occlusion hydration-gradient hydrogel Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9370926368c241bb9a08a72ba1d6ebc7
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spelling	oai:doaj.org-article:9370926368c241bb9a08a72ba1d6ebc72021-12-02T04:28:18ZThe role of surfactants in the formulation of elastic liposomal gels containing a synthetic opioid analgesic1178-2013https://doaj.org/article/9370926368c241bb9a08a72ba1d6ebc72016-04-01T00:00:00Zhttps://www.dovepress.com/the-role-of-surfactants-in-the-formulation-of-elastic-liposomal-gels-c-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Sima Singh,1,* Harsh Vardhan,1,* Niranjan G Kotla,2 Balaji Maddiboyina,3 Dinesh Sharma,4 Thomas J Webster5,6 1School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, India; 2Center for Research in Medical Devices, National University of Ireland, Galway, Ireland; 3Department of Pharmaceutics, Vishwabharathi College of Pharmaceutical Sciences, Guntur, India; 4Ranbaxy Laboratory Ltd, Gurgaon, India; 5Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 6Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia *These authors contributed equally to this work Abstract: Transdermal drug delivery systems have made significant contributions to the medical community, but have yet to completely substitute oral or parenteral delivery. Recently, various strategies have been used to augment the transdermal delivery of therapeutics. Primarily, they include iontophoresis, electrophoresis, sonophoresis, chemical permeation enhancers, microneedles, and vesicular systems. Among these strategies, elastic liposomes appear promising. Elastic vesicle scaffolds have been developed and evaluated as novel topical and transdermal delivery systems, with an infrastructure consisting of hydrophobic and hydrophilic moieties together, and as a result, such scaffolds can accommodate drug molecules with a wide range of solubility. High deformability of these vesicles provides for better penetration of intact vesicles. This system is much more efficient at delivering low- and high-molecular-weight drugs to the skin in terms of quantity and depth. In this work, elastic liposomes of Tramadol HCl were prepared using a solvent evaporation method with different surfactants and were characterized using microscopy, and particle size, shape, drug content, ex vivo release, and zeta potential were also calculated. The prepared elastic liposomes were found to be in the range of 152.4 nm with a zeta potential of -22.4 mV; the entrapment efficiencies of the selected formulation was found to be 79.71%±0.27%. All formulations in the form of a gel were evaluated for physicochemical properties and were found to be homogeneous with no grittiness, and the pH of all formulations was found to be neutral. The optimized selected elastic liposomal formulation followed the Higuchi equation and Fickian diffusion and released the drug for a period of 24 hours. The overall results provide much promise for the continued investigation of deformable vesicles as transdermal drug carriers. Keywords: elastic liposome, skin delivery, occlusion, hydration-gradient, hydrogelSingh SVardhan HKotla NGMaddiboyina BSharma DWebster TJDove Medical Pressarticleelastic liposomeskin deliveryocclusionhydration-gradienthydrogelMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 1475-1482 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	elastic liposome skin delivery occlusion hydration-gradient hydrogel Medicine (General) R5-920
spellingShingle	elastic liposome skin delivery occlusion hydration-gradient hydrogel Medicine (General) R5-920 Singh S Vardhan H Kotla NG Maddiboyina B Sharma D Webster TJ The role of surfactants in the formulation of elastic liposomal gels containing a synthetic opioid analgesic
description	Sima Singh,1,* Harsh Vardhan,1,* Niranjan G Kotla,2 Balaji Maddiboyina,3 Dinesh Sharma,4 Thomas J Webster5,6 1School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, India; 2Center for Research in Medical Devices, National University of Ireland, Galway, Ireland; 3Department of Pharmaceutics, Vishwabharathi College of Pharmaceutical Sciences, Guntur, India; 4Ranbaxy Laboratory Ltd, Gurgaon, India; 5Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 6Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia *These authors contributed equally to this work Abstract: Transdermal drug delivery systems have made significant contributions to the medical community, but have yet to completely substitute oral or parenteral delivery. Recently, various strategies have been used to augment the transdermal delivery of therapeutics. Primarily, they include iontophoresis, electrophoresis, sonophoresis, chemical permeation enhancers, microneedles, and vesicular systems. Among these strategies, elastic liposomes appear promising. Elastic vesicle scaffolds have been developed and evaluated as novel topical and transdermal delivery systems, with an infrastructure consisting of hydrophobic and hydrophilic moieties together, and as a result, such scaffolds can accommodate drug molecules with a wide range of solubility. High deformability of these vesicles provides for better penetration of intact vesicles. This system is much more efficient at delivering low- and high-molecular-weight drugs to the skin in terms of quantity and depth. In this work, elastic liposomes of Tramadol HCl were prepared using a solvent evaporation method with different surfactants and were characterized using microscopy, and particle size, shape, drug content, ex vivo release, and zeta potential were also calculated. The prepared elastic liposomes were found to be in the range of 152.4 nm with a zeta potential of -22.4 mV; the entrapment efficiencies of the selected formulation was found to be 79.71%±0.27%. All formulations in the form of a gel were evaluated for physicochemical properties and were found to be homogeneous with no grittiness, and the pH of all formulations was found to be neutral. The optimized selected elastic liposomal formulation followed the Higuchi equation and Fickian diffusion and released the drug for a period of 24 hours. The overall results provide much promise for the continued investigation of deformable vesicles as transdermal drug carriers. Keywords: elastic liposome, skin delivery, occlusion, hydration-gradient, hydrogel
format	article
author	Singh S Vardhan H Kotla NG Maddiboyina B Sharma D Webster TJ
author_facet	Singh S Vardhan H Kotla NG Maddiboyina B Sharma D Webster TJ
author_sort	Singh S
title	The role of surfactants in the formulation of elastic liposomal gels containing a synthetic opioid analgesic
title_short	The role of surfactants in the formulation of elastic liposomal gels containing a synthetic opioid analgesic
title_full	The role of surfactants in the formulation of elastic liposomal gels containing a synthetic opioid analgesic
title_fullStr	The role of surfactants in the formulation of elastic liposomal gels containing a synthetic opioid analgesic
title_full_unstemmed	The role of surfactants in the formulation of elastic liposomal gels containing a synthetic opioid analgesic
title_sort	role of surfactants in the formulation of elastic liposomal gels containing a synthetic opioid analgesic
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/9370926368c241bb9a08a72ba1d6ebc7
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The role of surfactants in the formulation of elastic liposomal gels containing a synthetic opioid analgesic

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