Anti-Emm, a rare specificity to the high-incidence antigen Emm in an Indian patient defining the new blood group system EMM (ISBT042)
A transfusion recipient lacking a high-incidence antigen (HIA) and has corresponding alloantibody pose a problem in providing compatible blood unit. We encountered a patient with an antibody to an HIA that required identification to assess if compatible blood could be organized. A 65-year-old male w...
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Wolters Kluwer Medknow Publications
2021
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oai:doaj.org-article:9373db1e07124ca3a70a60d2a6febe032021-11-12T10:08:28ZAnti-Emm, a rare specificity to the high-incidence antigen Emm in an Indian patient defining the new blood group system EMM (ISBT042)0973-62471998-356510.4103/ajts.ajts_59_21https://doaj.org/article/9373db1e07124ca3a70a60d2a6febe032021-01-01T00:00:00Zhttp://www.ajts.org/article.asp?issn=0973-6247;year=2021;volume=15;issue=2;spage=223;epage=225;aulast=Shahhttps://doaj.org/toc/0973-6247https://doaj.org/toc/1998-3565A transfusion recipient lacking a high-incidence antigen (HIA) and has corresponding alloantibody pose a problem in providing compatible blood unit. We encountered a patient with an antibody to an HIA that required identification to assess if compatible blood could be organized. A 65-year-old male was posted for coronary artery bypass grafting surgery. His blood specimen collected in EDTA was referred to the blood bank to provide blood for transfusion. The patient, grouped AB RhD+, had an antibody reacting in saline and antiglobulin phases. It agglutinated all the red blood cells (RBCs) of the 11-cell panel and random donors, indicating specificity to an HIA, though one of his siblings was compatible. After ruling out specificity to HIAs such as H, Inb, and INRA (IN5), the specimen was referred to the New York Blood Centre for further work-up. The antibody reacted with examples of red cells lacking HIA, except those with the Emm− phenotype. The patient's RBCs were typed as Emm−. Anti-Emm in the patient appeared to be naturally occurring as there was no history of transfusion. Naturally occurring alloantibody to an HIA, identified as anti-Emm in phenotype Emm−, is rare and the first of its kind to be reported from India. The case was instrumental in recognizing the Emm as the new blood group system assigned with the symbol ISBT042.Ripal J ShahSnehal B SenjaliyaV HarimoorthyAnna BurgosSunitha VegeChristine Lomas-FrancisConnie M WesthoffSanmukh Ratilal JoshiWolters Kluwer Medknow Publicationsarticleemmemm− phenotype in indian subjecthigh-incidence antigennew blood group systemDiseases of the blood and blood-forming organsRC633-647.5ENAsian Journal of Transfusion Science, Vol 15, Iss 2, Pp 223-225 (2021) |
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emm emm− phenotype in indian subject high-incidence antigen new blood group system Diseases of the blood and blood-forming organs RC633-647.5 |
| spellingShingle |
emm emm− phenotype in indian subject high-incidence antigen new blood group system Diseases of the blood and blood-forming organs RC633-647.5 Ripal J Shah Snehal B Senjaliya V Harimoorthy Anna Burgos Sunitha Vege Christine Lomas-Francis Connie M Westhoff Sanmukh Ratilal Joshi Anti-Emm, a rare specificity to the high-incidence antigen Emm in an Indian patient defining the new blood group system EMM (ISBT042) |
| description |
A transfusion recipient lacking a high-incidence antigen (HIA) and has corresponding alloantibody pose a problem in providing compatible blood unit. We encountered a patient with an antibody to an HIA that required identification to assess if compatible blood could be organized. A 65-year-old male was posted for coronary artery bypass grafting surgery. His blood specimen collected in EDTA was referred to the blood bank to provide blood for transfusion. The patient, grouped AB RhD+, had an antibody reacting in saline and antiglobulin phases. It agglutinated all the red blood cells (RBCs) of the 11-cell panel and random donors, indicating specificity to an HIA, though one of his siblings was compatible. After ruling out specificity to HIAs such as H, Inb, and INRA (IN5), the specimen was referred to the New York Blood Centre for further work-up. The antibody reacted with examples of red cells lacking HIA, except those with the Emm− phenotype. The patient's RBCs were typed as Emm−. Anti-Emm in the patient appeared to be naturally occurring as there was no history of transfusion. Naturally occurring alloantibody to an HIA, identified as anti-Emm in phenotype Emm−, is rare and the first of its kind to be reported from India. The case was instrumental in recognizing the Emm as the new blood group system assigned with the symbol ISBT042. |
| format |
article |
| author |
Ripal J Shah Snehal B Senjaliya V Harimoorthy Anna Burgos Sunitha Vege Christine Lomas-Francis Connie M Westhoff Sanmukh Ratilal Joshi |
| author_facet |
Ripal J Shah Snehal B Senjaliya V Harimoorthy Anna Burgos Sunitha Vege Christine Lomas-Francis Connie M Westhoff Sanmukh Ratilal Joshi |
| author_sort |
Ripal J Shah |
| title |
Anti-Emm, a rare specificity to the high-incidence antigen Emm in an Indian patient defining the new blood group system EMM (ISBT042) |
| title_short |
Anti-Emm, a rare specificity to the high-incidence antigen Emm in an Indian patient defining the new blood group system EMM (ISBT042) |
| title_full |
Anti-Emm, a rare specificity to the high-incidence antigen Emm in an Indian patient defining the new blood group system EMM (ISBT042) |
| title_fullStr |
Anti-Emm, a rare specificity to the high-incidence antigen Emm in an Indian patient defining the new blood group system EMM (ISBT042) |
| title_full_unstemmed |
Anti-Emm, a rare specificity to the high-incidence antigen Emm in an Indian patient defining the new blood group system EMM (ISBT042) |
| title_sort |
anti-emm, a rare specificity to the high-incidence antigen emm in an indian patient defining the new blood group system emm (isbt042) |
| publisher |
Wolters Kluwer Medknow Publications |
| publishDate |
2021 |
| url |
https://doaj.org/article/9373db1e07124ca3a70a60d2a6febe03 |
| work_keys_str_mv |
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