The genome-wide multi-layered architecture of chromosome pairing in early Drosophila embryos

Homologs are paired in Drosophila somatic cells from embryogenesis to adulthood. Using a computational approach for haplotype-resolved Hi-C, the authors reveal highly structured homolog pairing in Drosophila embryos during zygotic genome activation and demonstrate its application to mammalian embryo...

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Autores principales:	Jelena Erceg, Jumana AlHaj Abed, Anton Goloborodko, Bryan R. Lajoie, Geoffrey Fudenberg, Nezar Abdennur, Maxim Imakaev, Ruth B. McCole, Son C. Nguyen, Wren Saylor, Eric F. Joyce, T. Niroshini Senaratne, Mohammed A. Hannan, Guy Nir, Job Dekker, Leonid A. Mirny, C.-ting Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/93745053c3604cd7b79badd5961d288d
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spelling	oai:doaj.org-article:93745053c3604cd7b79badd5961d288d2021-12-02T17:32:55ZThe genome-wide multi-layered architecture of chromosome pairing in early Drosophila embryos10.1038/s41467-019-12211-82041-1723https://doaj.org/article/93745053c3604cd7b79badd5961d288d2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12211-8https://doaj.org/toc/2041-1723Homologs are paired in Drosophila somatic cells from embryogenesis to adulthood. Using a computational approach for haplotype-resolved Hi-C, the authors reveal highly structured homolog pairing in Drosophila embryos during zygotic genome activation and demonstrate its application to mammalian embryos.Jelena ErcegJumana AlHaj AbedAnton GoloborodkoBryan R. LajoieGeoffrey FudenbergNezar AbdennurMaxim ImakaevRuth B. McColeSon C. NguyenWren SaylorEric F. JoyceT. Niroshini SenaratneMohammed A. HannanGuy NirJob DekkerLeonid A. MirnyC.-ting WuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jelena Erceg Jumana AlHaj Abed Anton Goloborodko Bryan R. Lajoie Geoffrey Fudenberg Nezar Abdennur Maxim Imakaev Ruth B. McCole Son C. Nguyen Wren Saylor Eric F. Joyce T. Niroshini Senaratne Mohammed A. Hannan Guy Nir Job Dekker Leonid A. Mirny C.-ting Wu The genome-wide multi-layered architecture of chromosome pairing in early Drosophila embryos
description	Homologs are paired in Drosophila somatic cells from embryogenesis to adulthood. Using a computational approach for haplotype-resolved Hi-C, the authors reveal highly structured homolog pairing in Drosophila embryos during zygotic genome activation and demonstrate its application to mammalian embryos.
format	article
author	Jelena Erceg Jumana AlHaj Abed Anton Goloborodko Bryan R. Lajoie Geoffrey Fudenberg Nezar Abdennur Maxim Imakaev Ruth B. McCole Son C. Nguyen Wren Saylor Eric F. Joyce T. Niroshini Senaratne Mohammed A. Hannan Guy Nir Job Dekker Leonid A. Mirny C.-ting Wu
author_facet	Jelena Erceg Jumana AlHaj Abed Anton Goloborodko Bryan R. Lajoie Geoffrey Fudenberg Nezar Abdennur Maxim Imakaev Ruth B. McCole Son C. Nguyen Wren Saylor Eric F. Joyce T. Niroshini Senaratne Mohammed A. Hannan Guy Nir Job Dekker Leonid A. Mirny C.-ting Wu
author_sort	Jelena Erceg
title	The genome-wide multi-layered architecture of chromosome pairing in early Drosophila embryos
title_short	The genome-wide multi-layered architecture of chromosome pairing in early Drosophila embryos
title_full	The genome-wide multi-layered architecture of chromosome pairing in early Drosophila embryos
title_fullStr	The genome-wide multi-layered architecture of chromosome pairing in early Drosophila embryos
title_full_unstemmed	The genome-wide multi-layered architecture of chromosome pairing in early Drosophila embryos
title_sort	genome-wide multi-layered architecture of chromosome pairing in early drosophila embryos
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/93745053c3604cd7b79badd5961d288d
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The genome-wide multi-layered architecture of chromosome pairing in early Drosophila embryos

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