Central and peripheral clocks are coupled by a neuropeptide pathway in Drosophila

The emergence of the adult fruit flies from the pupae is jointly regulated by the central and peripheral clocks. Selchoet al. show that synchronization of the two clocks is mediated by the master clock brain neurons producing sNPF, and non-clock PTTH neurons that regulate the peripheral clock produc...

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Autores principales: Mareike Selcho, Carola Millán, Angelina Palacios-Muñoz, Franziska Ruf, Lilian Ubillo, Jiangtian Chen, Gregor Bergmann, Chihiro Ito, Valeria Silva, Christian Wegener, John Ewer
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/93748c81ccfb4e92857d11a399451f8e
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Sumario:The emergence of the adult fruit flies from the pupae is jointly regulated by the central and peripheral clocks. Selchoet al. show that synchronization of the two clocks is mediated by the master clock brain neurons producing sNPF, and non-clock PTTH neurons that regulate the peripheral clock producing the steroid moulting hormone, ecdysone.