Diabetes and Cancer: Risk, Challenges, Management and Outcomes

Background: Diabetes mellitus and cancer are commonly coexisting illnesses, and the global incidence and prevalence of both are rising. Cancer patients with diabetes face unique challenges. This review highlights the relationship between diabetes and cancer and various aspects of the management of d...

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Autores principales:	Rabia K. Shahid, Shahid Ahmed, Duc Le, Sunil Yadav
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	diabetes mellitus diabetes cancer hyperglycemia targeted therapy cancer therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/9374ee2f6de642ed8470a241a8a546c4
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spelling	oai:doaj.org-article:9374ee2f6de642ed8470a241a8a546c42021-11-25T17:03:23ZDiabetes and Cancer: Risk, Challenges, Management and Outcomes10.3390/cancers132257352072-6694https://doaj.org/article/9374ee2f6de642ed8470a241a8a546c42021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5735https://doaj.org/toc/2072-6694Background: Diabetes mellitus and cancer are commonly coexisting illnesses, and the global incidence and prevalence of both are rising. Cancer patients with diabetes face unique challenges. This review highlights the relationship between diabetes and cancer and various aspects of the management of diabetes in cancer patients. Methods: A literature search using keywords in PubMed was performed. Studies that were published in English prior to July 2021 were assessed and an overview of epidemiology, cancer risk, outcomes, treatment-related hyperglycemia and management of diabetes in cancer patients is provided. Results: Overall, 8–18% of cancer patients have diabetes as a comorbid medical condition. Diabetes is a risk factor for certain solid malignancies, such as pancreatic, liver, colon, breast, and endometrial cancer. Several novel targeted compounds and immunotherapies can cause hyperglycemia. Nevertheless, most patients undergoing cancer therapy can be managed with an appropriate glucose lowering agent without the need for discontinuation of cancer treatment. Evidence suggests that cancer patients with diabetes have higher cancer-related mortality; therefore, a multidisciplinary approach is important in the management of patients with diabetes and cancer for a better outcome. Conclusions: Future studies are required to better understand the underlying mechanism between the risk of cancer and diabetes. Furthermore, high-quality prospective studies evaluating management of diabetes in cancer patients using innovative tools are needed. A patient-centered approach is important in cancer patients with diabetes to avoid adverse outcomes.Rabia K. ShahidShahid AhmedDuc LeSunil YadavMDPI AGarticlediabetes mellitusdiabetescancerhyperglycemiatargeted therapycancer therapyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5735, p 5735 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes mellitus diabetes cancer hyperglycemia targeted therapy cancer therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	diabetes mellitus diabetes cancer hyperglycemia targeted therapy cancer therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Rabia K. Shahid Shahid Ahmed Duc Le Sunil Yadav Diabetes and Cancer: Risk, Challenges, Management and Outcomes
description	Background: Diabetes mellitus and cancer are commonly coexisting illnesses, and the global incidence and prevalence of both are rising. Cancer patients with diabetes face unique challenges. This review highlights the relationship between diabetes and cancer and various aspects of the management of diabetes in cancer patients. Methods: A literature search using keywords in PubMed was performed. Studies that were published in English prior to July 2021 were assessed and an overview of epidemiology, cancer risk, outcomes, treatment-related hyperglycemia and management of diabetes in cancer patients is provided. Results: Overall, 8–18% of cancer patients have diabetes as a comorbid medical condition. Diabetes is a risk factor for certain solid malignancies, such as pancreatic, liver, colon, breast, and endometrial cancer. Several novel targeted compounds and immunotherapies can cause hyperglycemia. Nevertheless, most patients undergoing cancer therapy can be managed with an appropriate glucose lowering agent without the need for discontinuation of cancer treatment. Evidence suggests that cancer patients with diabetes have higher cancer-related mortality; therefore, a multidisciplinary approach is important in the management of patients with diabetes and cancer for a better outcome. Conclusions: Future studies are required to better understand the underlying mechanism between the risk of cancer and diabetes. Furthermore, high-quality prospective studies evaluating management of diabetes in cancer patients using innovative tools are needed. A patient-centered approach is important in cancer patients with diabetes to avoid adverse outcomes.
format	article
author	Rabia K. Shahid Shahid Ahmed Duc Le Sunil Yadav
author_facet	Rabia K. Shahid Shahid Ahmed Duc Le Sunil Yadav
author_sort	Rabia K. Shahid
title	Diabetes and Cancer: Risk, Challenges, Management and Outcomes
title_short	Diabetes and Cancer: Risk, Challenges, Management and Outcomes
title_full	Diabetes and Cancer: Risk, Challenges, Management and Outcomes
title_fullStr	Diabetes and Cancer: Risk, Challenges, Management and Outcomes
title_full_unstemmed	Diabetes and Cancer: Risk, Challenges, Management and Outcomes
title_sort	diabetes and cancer: risk, challenges, management and outcomes
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9374ee2f6de642ed8470a241a8a546c4
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Diabetes and Cancer: Risk, Challenges, Management and Outcomes

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