Liver Decompensation as Late Complication in HCC Patients with Long-Term Response following Selective Internal Radiation Therapy

Selective internal radiation therapy (SIRT) is used as a treatment for hepatocellular carcinoma (HCC). The aim of this study was to assess long-term liver-related complications of SIRT in patients who had not developed radioembolization-induced liver disease (REILD). The primary outcome was the perc...

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Autores principales:	Diederick J. van Doorn, Pim Hendriks, Mark C. Burgmans, Daphne D. D. Rietbergen, Minneke J. Coenraad, Otto M. van Delden, Roel J. Bennink, Tim A. Labeur, Heinz-Josef Klümpen, Ferry A. L. M. Eskens, Adriaan Moelker, Erik Vegt, Dave Sprengers, Nahid Mostafavi, Jan Ijzermans, R. Bart Takkenberg
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hepatocellular carcinoma selective internal radiation therapy long-term response liver decompensation overall survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/9376008499c447289b8f566a65c2c793
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spelling	oai:doaj.org-article:9376008499c447289b8f566a65c2c7932021-11-11T15:31:18ZLiver Decompensation as Late Complication in HCC Patients with Long-Term Response following Selective Internal Radiation Therapy10.3390/cancers132154272072-6694https://doaj.org/article/9376008499c447289b8f566a65c2c7932021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5427https://doaj.org/toc/2072-6694Selective internal radiation therapy (SIRT) is used as a treatment for hepatocellular carcinoma (HCC). The aim of this study was to assess long-term liver-related complications of SIRT in patients who had not developed radioembolization-induced liver disease (REILD). The primary outcome was the percentage of patients without REILD that developed Child-Pugh (CP) ≥ B7 liver decompensation after SIRT. The secondary outcomes were overall survival (OS) and tumor response. These data were compared with a matched cohort of patients treated with sorafenib. Eighty-five patients were included, of whom 16 developed REILD. Of the remaining 69 patients, 38 developed liver decompensation CP ≥ B7. The median OS was 18 months. In patients without REILD, the median OS in patients with CP ≥ B7 was significantly shorter compared to those without CP ≥ B7; 16 vs. 31 months. In the case-matched analysis, the median OS was significantly longer in SIRT-treated patients; 16 vs. 8 months in sorafenib. Liver decompensation CP ≥ B7 occurred significantly more in SIRT when compared to sorafenib; 62% vs. 27%. The ALBI score was an independent predictor of liver decompensation (OR 0.07) and OS (HR 2.83). After SIRT, liver decompensation CP ≥ B7 often developed as a late complication in HCC patients and was associated with a shorter OS. The ALBI score was predictive of CP ≥ B7 liver decompensation and the OS, and this may be a valuable marker for patient selection for SIRT.Diederick J. van DoornPim HendriksMark C. BurgmansDaphne D. D. RietbergenMinneke J. CoenraadOtto M. van DeldenRoel J. BenninkTim A. LabeurHeinz-Josef KlümpenFerry A. L. M. EskensAdriaan MoelkerErik VegtDave SprengersNahid MostafaviJan IjzermansR. Bart TakkenbergMDPI AGarticlehepatocellular carcinomaselective internal radiation therapylong-term responseliver decompensationoverall survivalNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5427, p 5427 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatocellular carcinoma selective internal radiation therapy long-term response liver decompensation overall survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	hepatocellular carcinoma selective internal radiation therapy long-term response liver decompensation overall survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Diederick J. van Doorn Pim Hendriks Mark C. Burgmans Daphne D. D. Rietbergen Minneke J. Coenraad Otto M. van Delden Roel J. Bennink Tim A. Labeur Heinz-Josef Klümpen Ferry A. L. M. Eskens Adriaan Moelker Erik Vegt Dave Sprengers Nahid Mostafavi Jan Ijzermans R. Bart Takkenberg Liver Decompensation as Late Complication in HCC Patients with Long-Term Response following Selective Internal Radiation Therapy
description	Selective internal radiation therapy (SIRT) is used as a treatment for hepatocellular carcinoma (HCC). The aim of this study was to assess long-term liver-related complications of SIRT in patients who had not developed radioembolization-induced liver disease (REILD). The primary outcome was the percentage of patients without REILD that developed Child-Pugh (CP) ≥ B7 liver decompensation after SIRT. The secondary outcomes were overall survival (OS) and tumor response. These data were compared with a matched cohort of patients treated with sorafenib. Eighty-five patients were included, of whom 16 developed REILD. Of the remaining 69 patients, 38 developed liver decompensation CP ≥ B7. The median OS was 18 months. In patients without REILD, the median OS in patients with CP ≥ B7 was significantly shorter compared to those without CP ≥ B7; 16 vs. 31 months. In the case-matched analysis, the median OS was significantly longer in SIRT-treated patients; 16 vs. 8 months in sorafenib. Liver decompensation CP ≥ B7 occurred significantly more in SIRT when compared to sorafenib; 62% vs. 27%. The ALBI score was an independent predictor of liver decompensation (OR 0.07) and OS (HR 2.83). After SIRT, liver decompensation CP ≥ B7 often developed as a late complication in HCC patients and was associated with a shorter OS. The ALBI score was predictive of CP ≥ B7 liver decompensation and the OS, and this may be a valuable marker for patient selection for SIRT.
format	article
author	Diederick J. van Doorn Pim Hendriks Mark C. Burgmans Daphne D. D. Rietbergen Minneke J. Coenraad Otto M. van Delden Roel J. Bennink Tim A. Labeur Heinz-Josef Klümpen Ferry A. L. M. Eskens Adriaan Moelker Erik Vegt Dave Sprengers Nahid Mostafavi Jan Ijzermans R. Bart Takkenberg
author_facet	Diederick J. van Doorn Pim Hendriks Mark C. Burgmans Daphne D. D. Rietbergen Minneke J. Coenraad Otto M. van Delden Roel J. Bennink Tim A. Labeur Heinz-Josef Klümpen Ferry A. L. M. Eskens Adriaan Moelker Erik Vegt Dave Sprengers Nahid Mostafavi Jan Ijzermans R. Bart Takkenberg
author_sort	Diederick J. van Doorn
title	Liver Decompensation as Late Complication in HCC Patients with Long-Term Response following Selective Internal Radiation Therapy
title_short	Liver Decompensation as Late Complication in HCC Patients with Long-Term Response following Selective Internal Radiation Therapy
title_full	Liver Decompensation as Late Complication in HCC Patients with Long-Term Response following Selective Internal Radiation Therapy
title_fullStr	Liver Decompensation as Late Complication in HCC Patients with Long-Term Response following Selective Internal Radiation Therapy
title_full_unstemmed	Liver Decompensation as Late Complication in HCC Patients with Long-Term Response following Selective Internal Radiation Therapy
title_sort	liver decompensation as late complication in hcc patients with long-term response following selective internal radiation therapy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9376008499c447289b8f566a65c2c793
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Liver Decompensation as Late Complication in HCC Patients with Long-Term Response following Selective Internal Radiation Therapy

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