Delivering hydrophilic and hydrophobic chemotherapeutics simultaneously by magnetic mesoporous silica nanoparticles to inhibit cancer cells

Qian Liu*, Jixi Zhang*, Wei Sun, Qian Reuben Xie, Weiliang Xia, Hongchen Gu School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, People&#39;s Republic of China*These authors contributed equally to this workAbstract: Using nanoparticles to de...

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Autores principales:	Xia W, Xie QR, Sun W, Zhang J, Liu Q, Gu H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/938d6bb323ef4597b798e9a7def5ab9a
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spelling	oai:doaj.org-article:938d6bb323ef4597b798e9a7def5ab9a2021-12-02T06:26:19ZDelivering hydrophilic and hydrophobic chemotherapeutics simultaneously by magnetic mesoporous silica nanoparticles to inhibit cancer cells1176-91141178-2013https://doaj.org/article/938d6bb323ef4597b798e9a7def5ab9a2012-02-01T00:00:00Zhttp://www.dovepress.com/delivering-hydrophilic-and-hydrophobic-chemotherapeutics-simultaneousl-a9351https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Qian Liu, Jixi Zhang, Wei Sun, Qian Reuben Xie, Weiliang Xia, Hongchen Gu School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, People&#39;s Republic of China*These authors contributed equally to this workAbstract: Using nanoparticles to deliver chemotherapeutics offers new opportunities for cancer therapy, but challenges still remain when they are used for the delivery of multiple drugs, especially for the synchronous delivery of hydrophilic and hydrophobic drugs in combination therapies. In this paper, we developed an approach to deliver hydrophilic&ndash;hydrophobic anticancer drug pairs by employing magnetic mesoporous silica nanoparticles (MMSNs). We prepared 50 nm-sized MMSNs with uniform pore size and evaluated their capability for the loading of two combinations of chemotherapeutics, namely doxorubicin&ndash;paclitaxel and doxorubicin&ndash; rapamycin, by means of sequential adsorption from the aqueous solution of doxorubicin and nonaqueous solutions of paclitaxel or rapamycin. Experimental results showed that the present strategy successfully realized the co-loading of hydrophilic and hydrophobic drugs with high-loading content and widely tunable ratio range. We elaborate on the theory behind the molecular interaction between the silica hydroxyl groups and drug molecules, which underlie the controllable loading, and the subsequent release of the drug pairs. Then we demonstrate that the multidrug-loaded MMSNs could be easily internalized by A549 human pulmonary adenocarcinoma cells, and produce enhanced tumor cell apoptosis and growth inhibition as compared to single-drug loaded MMSNs. Our study thus realized simultaneous and dose-tunable delivery of hydrophilic and hydrophobic drugs, which were endowed with improved anticancer efficacy. This strategy could be readily extended to other chemotherapeutic combinations and might have clinically translatable significance.Keywords: co-delivery, combination chemotherapy, doxorubicin, mesoporous nanoparticlesXia WXie QRSun WZhang JLiu QGu HDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 999-1013 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Xia W Xie QR Sun W Zhang J Liu Q Gu H Delivering hydrophilic and hydrophobic chemotherapeutics simultaneously by magnetic mesoporous silica nanoparticles to inhibit cancer cells
description	Qian Liu, Jixi Zhang, Wei Sun, Qian Reuben Xie, Weiliang Xia, Hongchen Gu School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, People&#39;s Republic of China*These authors contributed equally to this workAbstract: Using nanoparticles to deliver chemotherapeutics offers new opportunities for cancer therapy, but challenges still remain when they are used for the delivery of multiple drugs, especially for the synchronous delivery of hydrophilic and hydrophobic drugs in combination therapies. In this paper, we developed an approach to deliver hydrophilic&ndash;hydrophobic anticancer drug pairs by employing magnetic mesoporous silica nanoparticles (MMSNs). We prepared 50 nm-sized MMSNs with uniform pore size and evaluated their capability for the loading of two combinations of chemotherapeutics, namely doxorubicin&ndash;paclitaxel and doxorubicin&ndash; rapamycin, by means of sequential adsorption from the aqueous solution of doxorubicin and nonaqueous solutions of paclitaxel or rapamycin. Experimental results showed that the present strategy successfully realized the co-loading of hydrophilic and hydrophobic drugs with high-loading content and widely tunable ratio range. We elaborate on the theory behind the molecular interaction between the silica hydroxyl groups and drug molecules, which underlie the controllable loading, and the subsequent release of the drug pairs. Then we demonstrate that the multidrug-loaded MMSNs could be easily internalized by A549 human pulmonary adenocarcinoma cells, and produce enhanced tumor cell apoptosis and growth inhibition as compared to single-drug loaded MMSNs. Our study thus realized simultaneous and dose-tunable delivery of hydrophilic and hydrophobic drugs, which were endowed with improved anticancer efficacy. This strategy could be readily extended to other chemotherapeutic combinations and might have clinically translatable significance.Keywords: co-delivery, combination chemotherapy, doxorubicin, mesoporous nanoparticles
format	article
author	Xia W Xie QR Sun W Zhang J Liu Q Gu H
author_facet	Xia W Xie QR Sun W Zhang J Liu Q Gu H
author_sort	Xia W
title	Delivering hydrophilic and hydrophobic chemotherapeutics simultaneously by magnetic mesoporous silica nanoparticles to inhibit cancer cells
title_short	Delivering hydrophilic and hydrophobic chemotherapeutics simultaneously by magnetic mesoporous silica nanoparticles to inhibit cancer cells
title_full	Delivering hydrophilic and hydrophobic chemotherapeutics simultaneously by magnetic mesoporous silica nanoparticles to inhibit cancer cells
title_fullStr	Delivering hydrophilic and hydrophobic chemotherapeutics simultaneously by magnetic mesoporous silica nanoparticles to inhibit cancer cells
title_full_unstemmed	Delivering hydrophilic and hydrophobic chemotherapeutics simultaneously by magnetic mesoporous silica nanoparticles to inhibit cancer cells
title_sort	delivering hydrophilic and hydrophobic chemotherapeutics simultaneously by magnetic mesoporous silica nanoparticles to inhibit cancer cells
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/938d6bb323ef4597b798e9a7def5ab9a
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Delivering hydrophilic and hydrophobic chemotherapeutics simultaneously by magnetic mesoporous silica nanoparticles to inhibit cancer cells

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