Treatment with bimatoprost for exophthalmos in patients with inactive thyroid-associated ophthalmopathy

Tomoaki Higashiyama, Masahito Ohji Department of Ophthalmology, Shiga University of Medical Science, Otsu, Japan Purpose: This study was performed to observe changes prospectively in exophthalmos and orbital fat in patients with inactive thyroid-associated ophthalmopathy (TAO) treated with bimatop...

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Autores principales:	Higashiyama T, Ohji M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Bimatoprost Thyroid-associated ophthalmopathy Exophthalmos Orbital fat Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/938e3ba68e7049269ca7278e9742134b
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spelling	oai:doaj.org-article:938e3ba68e7049269ca7278e9742134b2021-12-02T02:56:23ZTreatment with bimatoprost for exophthalmos in patients with inactive thyroid-associated ophthalmopathy1177-5483https://doaj.org/article/938e3ba68e7049269ca7278e9742134b2018-11-01T00:00:00Zhttps://www.dovepress.com/treatment-with-bimatoprost-for-exophthalmos-in-patients-with-inactive--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Tomoaki Higashiyama, Masahito Ohji Department of Ophthalmology, Shiga University of Medical Science, Otsu, Japan Purpose: This study was performed to observe changes prospectively in exophthalmos and orbital fat in patients with inactive thyroid-associated ophthalmopathy (TAO) treated with bimatoprost. Methods: In this 12-month single-treatment pilot observational study, 13 patients with inactive-phase TAO were administered bimatoprost to treat exophthalmos due to TAO. Exophthalmos values and orbital tissue volumes were measured on MRI by technicians in a masked fashion. Results: Nine orbits of nine patients (eight women, one man) were treated with bimatoprost for 12 months. Mean exophthalmos values before and after treatment were 21.7±2.2 and 21.7±2.0 mm, respectively. The mean value after 12 months of treatment was not significantly different from before treatment (P=0.82). Mean orbital fat volume before and after 12 months of treatment was 17.2±2.5 and 17.0±3.0 cm3, respectively. The corresponding total extraocular muscle volume was 4.0±0.7 and 3.8±0.9 cm3, respectively. Mean volume in each tissue type after 12 months of treatment was not significantly different from before treatment (orbital fat, P=0.70; extraocular muscles, P=0.32). Conclusion: Topical bimatoprost treatment did not reduce exophthalmos or orbital fat in this cohort of patients with inactive TAO. Keywords: bimatoprost, thyroid-associated ophthalmopathy, exophthalmos, orbital fatHigashiyama TOhji MDove Medical PressarticleBimatoprostThyroid-associated ophthalmopathyExophthalmosOrbital fatOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 2415-2421 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bimatoprost Thyroid-associated ophthalmopathy Exophthalmos Orbital fat Ophthalmology RE1-994
spellingShingle	Bimatoprost Thyroid-associated ophthalmopathy Exophthalmos Orbital fat Ophthalmology RE1-994 Higashiyama T Ohji M Treatment with bimatoprost for exophthalmos in patients with inactive thyroid-associated ophthalmopathy
description	Tomoaki Higashiyama, Masahito Ohji Department of Ophthalmology, Shiga University of Medical Science, Otsu, Japan Purpose: This study was performed to observe changes prospectively in exophthalmos and orbital fat in patients with inactive thyroid-associated ophthalmopathy (TAO) treated with bimatoprost. Methods: In this 12-month single-treatment pilot observational study, 13 patients with inactive-phase TAO were administered bimatoprost to treat exophthalmos due to TAO. Exophthalmos values and orbital tissue volumes were measured on MRI by technicians in a masked fashion. Results: Nine orbits of nine patients (eight women, one man) were treated with bimatoprost for 12 months. Mean exophthalmos values before and after treatment were 21.7±2.2 and 21.7±2.0 mm, respectively. The mean value after 12 months of treatment was not significantly different from before treatment (P=0.82). Mean orbital fat volume before and after 12 months of treatment was 17.2±2.5 and 17.0±3.0 cm3, respectively. The corresponding total extraocular muscle volume was 4.0±0.7 and 3.8±0.9 cm3, respectively. Mean volume in each tissue type after 12 months of treatment was not significantly different from before treatment (orbital fat, P=0.70; extraocular muscles, P=0.32). Conclusion: Topical bimatoprost treatment did not reduce exophthalmos or orbital fat in this cohort of patients with inactive TAO. Keywords: bimatoprost, thyroid-associated ophthalmopathy, exophthalmos, orbital fat
format	article
author	Higashiyama T Ohji M
author_facet	Higashiyama T Ohji M
author_sort	Higashiyama T
title	Treatment with bimatoprost for exophthalmos in patients with inactive thyroid-associated ophthalmopathy
title_short	Treatment with bimatoprost for exophthalmos in patients with inactive thyroid-associated ophthalmopathy
title_full	Treatment with bimatoprost for exophthalmos in patients with inactive thyroid-associated ophthalmopathy
title_fullStr	Treatment with bimatoprost for exophthalmos in patients with inactive thyroid-associated ophthalmopathy
title_full_unstemmed	Treatment with bimatoprost for exophthalmos in patients with inactive thyroid-associated ophthalmopathy
title_sort	treatment with bimatoprost for exophthalmos in patients with inactive thyroid-associated ophthalmopathy
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/938e3ba68e7049269ca7278e9742134b
work_keys_str_mv	AT higashiyamat treatmentwithbimatoprostforexophthalmosinpatientswithinactivethyroidassociatedophthalmopathy AT ohjim treatmentwithbimatoprostforexophthalmosinpatientswithinactivethyroidassociatedophthalmopathy
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Treatment with bimatoprost for exophthalmos in patients with inactive thyroid-associated ophthalmopathy

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