Inhibition of the mitochondrial enzyme ABAD restores the amyloid-β-mediated deregulation of estradiol.
Alzheimer's disease (AD) is a conformational disease that is characterized by amyloid-β (Aβ) deposition in the brain. Aβ exerts its toxicity in part by receptor-mediated interactions that cause down-stream protein misfolding and aggregation, as well as mitochondrial dysfunction. Recent reports...
Guardado en:
Autores principales: | Yun-An Lim, Amandine Grimm, Maria Giese, Ayikoe Guy Mensah-Nyagan, J Ernest Villafranca, Lars M Ittner, Anne Eckert, Jürgen Götz |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2011
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Materias: | |
Acceso en línea: | https://doaj.org/article/939330ec41c24ee59baa3fd8d8832f0f |
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