Inaccuracy of a non-invasive estimation of pulmonary vascular resistance assessed by cardiovascular magnetic resonance in heart failure patients

Inaccuracy of a non-invasive estimation of pulmonary vascular resistance assessed by cardiovascular magnetic resonance in heart failure patients

Abstract Pulmonary vascular resistance (PVR) is a marker of pulmonary vascular remodeling. A non-invasive model assessed by cardiovascular magnetic resonance (CMR) has been proposed to estimate PVR. However, its accuracy has not yet been evaluated in patients with heart failure. We prospectively inc...

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Autores principales: Eva Rumiz, Andrés Cubillos, Juan Vicente Vilar, Pilar García, Alberto Berenguer, Lorenzo Fácila, Ernesto Valero, Verónica Vidal, Salvador Morell, Julio Nuñez
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Publicado: Nature Portfolio 2021
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spelling oai:doaj.org-article:9393ec7252a8465b83686fe1ddd5633d2021-12-02T18:51:47ZInaccuracy of a non-invasive estimation of pulmonary vascular resistance assessed by cardiovascular magnetic resonance in heart failure patients10.1038/s41598-021-95897-52045-2322https://doaj.org/article/9393ec7252a8465b83686fe1ddd5633d2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95897-5https://doaj.org/toc/2045-2322Abstract Pulmonary vascular resistance (PVR) is a marker of pulmonary vascular remodeling. A non-invasive model assessed by cardiovascular magnetic resonance (CMR) has been proposed to estimate PVR. However, its accuracy has not yet been evaluated in patients with heart failure. We prospectively included 108 patients admitted with acute heart failure (AHF), in whom a right heart catheterization (RHC) and CMR were performed at the same day. PVR was estimated by CMR applying the model: PVR = 19.38 − [4.62 × Ln pulmonary artery average velocity (in cm/s)] − [0.08 × right ventricle ejection fraction (in %)], and by RHC using standard formulae. The median age of the cohort was 67 years (interquartile range 58–73), and 34% were females. The median of PVR assessed by RHC and CMR were 2.2 WU (1.5–4) and 5 WU (3.4–7), respectively. We found a weak correlation between invasive PVR and PVR assessed by CMR (Spearman r = 0.21, p = 0.02). The area under the ROC curve for PVR assessed by CMR to detect PVR ≥ 3 WU was 0.57, 95% confidence interval (CI): 0.47–0.68. In patients with AHF, the non-invasive estimation of PVR using CMR shows poor accuracy, as well as a limited capacity to discriminate increased PVR values.Eva RumizAndrés CubillosJuan Vicente VilarPilar GarcíaAlberto BerenguerLorenzo FácilaErnesto ValeroVerónica VidalSalvador MorellJulio NuñezNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Eva Rumiz
Andrés Cubillos
Juan Vicente Vilar
Pilar García
Alberto Berenguer
Lorenzo Fácila
Ernesto Valero
Verónica Vidal
Salvador Morell
Julio Nuñez
Inaccuracy of a non-invasive estimation of pulmonary vascular resistance assessed by cardiovascular magnetic resonance in heart failure patients
description Abstract Pulmonary vascular resistance (PVR) is a marker of pulmonary vascular remodeling. A non-invasive model assessed by cardiovascular magnetic resonance (CMR) has been proposed to estimate PVR. However, its accuracy has not yet been evaluated in patients with heart failure. We prospectively included 108 patients admitted with acute heart failure (AHF), in whom a right heart catheterization (RHC) and CMR were performed at the same day. PVR was estimated by CMR applying the model: PVR = 19.38 − [4.62 × Ln pulmonary artery average velocity (in cm/s)] − [0.08 × right ventricle ejection fraction (in %)], and by RHC using standard formulae. The median age of the cohort was 67 years (interquartile range 58–73), and 34% were females. The median of PVR assessed by RHC and CMR were 2.2 WU (1.5–4) and 5 WU (3.4–7), respectively. We found a weak correlation between invasive PVR and PVR assessed by CMR (Spearman r = 0.21, p = 0.02). The area under the ROC curve for PVR assessed by CMR to detect PVR ≥ 3 WU was 0.57, 95% confidence interval (CI): 0.47–0.68. In patients with AHF, the non-invasive estimation of PVR using CMR shows poor accuracy, as well as a limited capacity to discriminate increased PVR values.
format article
author Eva Rumiz
Andrés Cubillos
Juan Vicente Vilar
Pilar García
Alberto Berenguer
Lorenzo Fácila
Ernesto Valero
Verónica Vidal
Salvador Morell
Julio Nuñez
author_facet Eva Rumiz
Andrés Cubillos
Juan Vicente Vilar
Pilar García
Alberto Berenguer
Lorenzo Fácila
Ernesto Valero
Verónica Vidal
Salvador Morell
Julio Nuñez
author_sort Eva Rumiz
title Inaccuracy of a non-invasive estimation of pulmonary vascular resistance assessed by cardiovascular magnetic resonance in heart failure patients
title_short Inaccuracy of a non-invasive estimation of pulmonary vascular resistance assessed by cardiovascular magnetic resonance in heart failure patients
title_full Inaccuracy of a non-invasive estimation of pulmonary vascular resistance assessed by cardiovascular magnetic resonance in heart failure patients
title_fullStr Inaccuracy of a non-invasive estimation of pulmonary vascular resistance assessed by cardiovascular magnetic resonance in heart failure patients
title_full_unstemmed Inaccuracy of a non-invasive estimation of pulmonary vascular resistance assessed by cardiovascular magnetic resonance in heart failure patients
title_sort inaccuracy of a non-invasive estimation of pulmonary vascular resistance assessed by cardiovascular magnetic resonance in heart failure patients
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/9393ec7252a8465b83686fe1ddd5633d
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