GREB1 induced by Wnt signaling promotes development of hepatoblastoma by suppressing TGFβ signaling

The mechanisms promoting hepatoblastoma (HB) progression through Wnt/β-catenin signaling are unclear. Here, the authors show that the Wnt/ β-catenin axis induces GREB1 expression and nuclear localization, and suppresses TGFβ pathway, and propose GREB1 as a therapeutic target in HB.

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Autores principales:	Shinji Matsumoto, Taku Yamamichi, Koei Shinzawa, Yuuya Kasahara, Satoshi Nojima, Takahiro Kodama, Satoshi Obika, Tetsuo Takehara, Eiichi Morii, Hiroomi Okuyama, Akira Kikuchi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9394e1f418b34459a5c6f905377fa254
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spelling	oai:doaj.org-article:9394e1f418b34459a5c6f905377fa2542021-12-02T16:58:04ZGREB1 induced by Wnt signaling promotes development of hepatoblastoma by suppressing TGFβ signaling10.1038/s41467-019-11533-x2041-1723https://doaj.org/article/9394e1f418b34459a5c6f905377fa2542019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11533-xhttps://doaj.org/toc/2041-1723The mechanisms promoting hepatoblastoma (HB) progression through Wnt/β-catenin signaling are unclear. Here, the authors show that the Wnt/ β-catenin axis induces GREB1 expression and nuclear localization, and suppresses TGFβ pathway, and propose GREB1 as a therapeutic target in HB.Shinji MatsumotoTaku YamamichiKoei ShinzawaYuuya KasaharaSatoshi NojimaTakahiro KodamaSatoshi ObikaTetsuo TakeharaEiichi MoriiHiroomi OkuyamaAkira KikuchiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shinji Matsumoto Taku Yamamichi Koei Shinzawa Yuuya Kasahara Satoshi Nojima Takahiro Kodama Satoshi Obika Tetsuo Takehara Eiichi Morii Hiroomi Okuyama Akira Kikuchi GREB1 induced by Wnt signaling promotes development of hepatoblastoma by suppressing TGFβ signaling
description	The mechanisms promoting hepatoblastoma (HB) progression through Wnt/β-catenin signaling are unclear. Here, the authors show that the Wnt/ β-catenin axis induces GREB1 expression and nuclear localization, and suppresses TGFβ pathway, and propose GREB1 as a therapeutic target in HB.
format	article
author	Shinji Matsumoto Taku Yamamichi Koei Shinzawa Yuuya Kasahara Satoshi Nojima Takahiro Kodama Satoshi Obika Tetsuo Takehara Eiichi Morii Hiroomi Okuyama Akira Kikuchi
author_facet	Shinji Matsumoto Taku Yamamichi Koei Shinzawa Yuuya Kasahara Satoshi Nojima Takahiro Kodama Satoshi Obika Tetsuo Takehara Eiichi Morii Hiroomi Okuyama Akira Kikuchi
author_sort	Shinji Matsumoto
title	GREB1 induced by Wnt signaling promotes development of hepatoblastoma by suppressing TGFβ signaling
title_short	GREB1 induced by Wnt signaling promotes development of hepatoblastoma by suppressing TGFβ signaling
title_full	GREB1 induced by Wnt signaling promotes development of hepatoblastoma by suppressing TGFβ signaling
title_fullStr	GREB1 induced by Wnt signaling promotes development of hepatoblastoma by suppressing TGFβ signaling
title_full_unstemmed	GREB1 induced by Wnt signaling promotes development of hepatoblastoma by suppressing TGFβ signaling
title_sort	greb1 induced by wnt signaling promotes development of hepatoblastoma by suppressing tgfβ signaling
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9394e1f418b34459a5c6f905377fa254
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GREB1 induced by Wnt signaling promotes development of hepatoblastoma by suppressing TGFβ signaling

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