How to Control the Microfluidic Flow and Separate the Magnetic and Non-Magnetic Particles in the Runner of a Disc

Biochips play an important role in both medical and food industry safety testing. Moreover, magnetic activated cell sorting is a well-established technology for biochip development. However, biochips need to be manufactured by precision instruments, resulting in the high cost of biochips. Therefore,...

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Autores principales:	Yao-Tsung Lin, Chien-Sheng Huang, Shi-Chang Tseng
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	magnetic-activated disc microfluidic stomach-shape rectangular-shape spin Mechanical engineering and machinery TJ1-1570
Acceso en línea:	https://doaj.org/article/939b585600e14928a1faae241ae8ff6c
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id	oai:doaj.org-article:939b585600e14928a1faae241ae8ff6c
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spelling	oai:doaj.org-article:939b585600e14928a1faae241ae8ff6c2021-11-25T18:23:13ZHow to Control the Microfluidic Flow and Separate the Magnetic and Non-Magnetic Particles in the Runner of a Disc10.3390/mi121113352072-666Xhttps://doaj.org/article/939b585600e14928a1faae241ae8ff6c2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-666X/12/11/1335https://doaj.org/toc/2072-666XBiochips play an important role in both medical and food industry safety testing. Moreover, magnetic activated cell sorting is a well-established technology for biochip development. However, biochips need to be manufactured by precision instruments, resulting in the high cost of biochips. Therefore, this study used magnetic-activation and mechanics theories to create a novel disc that could manipulate the microfluidic flow, mixing, reaction, and separation on the runner of the disc. The goal of the research was to apply in the field of biomedical detection systems to reduce the cost of biochips and simplify the operation process. The simulation and experimental investigation showed that the pattern of the reaction chamber was stomach-shaped and the reservoir chamber was rectangular-shaped on the disc. The microfluid could be controlled to flow to the reaction chamber from the buffer and sample chamber when the disc spun at 175~200 rpm within three minutes. This was defined as the first setting mode. The microfluid could then be controlled to flow to the reservoir chamber from the reaction chamber when the disc spun at 225 rpm within five to ten minutes. This was defined as the second setting mode. This verified that the pattern design of the disc was optimized for control of the microfluid flow, mixing, reaction, and separation in the runner of the disc by different setting modes.Yao-Tsung LinChien-Sheng HuangShi-Chang TsengMDPI AGarticlemagnetic-activateddiscmicrofluidicstomach-shaperectangular-shapespinMechanical engineering and machineryTJ1-1570ENMicromachines, Vol 12, Iss 1335, p 1335 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	magnetic-activated disc microfluidic stomach-shape rectangular-shape spin Mechanical engineering and machinery TJ1-1570
spellingShingle	magnetic-activated disc microfluidic stomach-shape rectangular-shape spin Mechanical engineering and machinery TJ1-1570 Yao-Tsung Lin Chien-Sheng Huang Shi-Chang Tseng How to Control the Microfluidic Flow and Separate the Magnetic and Non-Magnetic Particles in the Runner of a Disc
description	Biochips play an important role in both medical and food industry safety testing. Moreover, magnetic activated cell sorting is a well-established technology for biochip development. However, biochips need to be manufactured by precision instruments, resulting in the high cost of biochips. Therefore, this study used magnetic-activation and mechanics theories to create a novel disc that could manipulate the microfluidic flow, mixing, reaction, and separation on the runner of the disc. The goal of the research was to apply in the field of biomedical detection systems to reduce the cost of biochips and simplify the operation process. The simulation and experimental investigation showed that the pattern of the reaction chamber was stomach-shaped and the reservoir chamber was rectangular-shaped on the disc. The microfluid could be controlled to flow to the reaction chamber from the buffer and sample chamber when the disc spun at 175~200 rpm within three minutes. This was defined as the first setting mode. The microfluid could then be controlled to flow to the reservoir chamber from the reaction chamber when the disc spun at 225 rpm within five to ten minutes. This was defined as the second setting mode. This verified that the pattern design of the disc was optimized for control of the microfluid flow, mixing, reaction, and separation in the runner of the disc by different setting modes.
format	article
author	Yao-Tsung Lin Chien-Sheng Huang Shi-Chang Tseng
author_facet	Yao-Tsung Lin Chien-Sheng Huang Shi-Chang Tseng
author_sort	Yao-Tsung Lin
title	How to Control the Microfluidic Flow and Separate the Magnetic and Non-Magnetic Particles in the Runner of a Disc
title_short	How to Control the Microfluidic Flow and Separate the Magnetic and Non-Magnetic Particles in the Runner of a Disc
title_full	How to Control the Microfluidic Flow and Separate the Magnetic and Non-Magnetic Particles in the Runner of a Disc
title_fullStr	How to Control the Microfluidic Flow and Separate the Magnetic and Non-Magnetic Particles in the Runner of a Disc
title_full_unstemmed	How to Control the Microfluidic Flow and Separate the Magnetic and Non-Magnetic Particles in the Runner of a Disc
title_sort	how to control the microfluidic flow and separate the magnetic and non-magnetic particles in the runner of a disc
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/939b585600e14928a1faae241ae8ff6c
work_keys_str_mv	AT yaotsunglin howtocontrolthemicrofluidicflowandseparatethemagneticandnonmagneticparticlesintherunnerofadisc AT chienshenghuang howtocontrolthemicrofluidicflowandseparatethemagneticandnonmagneticparticlesintherunnerofadisc AT shichangtseng howtocontrolthemicrofluidicflowandseparatethemagneticandnonmagneticparticlesintherunnerofadisc
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How to Control the Microfluidic Flow and Separate the Magnetic and Non-Magnetic Particles in the Runner of a Disc

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