Folate status in type 2 diabetic patients with and without retinopathy

Folate status in type 2 diabetic patients with and without retinopathy

Giulia Malaguarnera,1 Caterina Gagliano,2,3 Salvatore Salomone,1 Maria Giordano,4 Claudio Bucolo,1 Antonino Pappalardo,5 Filippo Drago,1 Filippo Caraci,6,7 Teresio Avitabile,2 Massimo Motta51Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy; 2Department of...

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Autores principales: Malaguarnera G, Gagliano C, Salomone S, Giordano M, Bucolo C, Pappalardo A, Drago F, Caraci F, Avitabile T, Motta M
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2015
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Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/939cd3da8b1a4981b663530d10f2ce1f
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spelling oai:doaj.org-article:939cd3da8b1a4981b663530d10f2ce1f2021-12-02T06:28:07ZFolate status in type 2 diabetic patients with and without retinopathy1177-5483https://doaj.org/article/939cd3da8b1a4981b663530d10f2ce1f2015-08-01T00:00:00Zhttp://www.dovepress.com/folate-status-in-type-2-diabetic-patients-withnbspand-without-retinopa-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Giulia Malaguarnera,1 Caterina Gagliano,2,3 Salvatore Salomone,1 Maria Giordano,4 Claudio Bucolo,1 Antonino Pappalardo,5 Filippo Drago,1 Filippo Caraci,6,7 Teresio Avitabile,2 Massimo Motta51Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy; 2Department of Ophthalmology, University of Catania, Catania, Italy; 3Neurovisual Science Technology (NEST), Catania, Catania, Italy; 4Gerontology and Bone Metabolic Disease Section, Department of Medical Sciences, University of Turin, Turin; 5Department of Medical and Paediatric Sciences, University of Catania, Italy; 6Department of Drug Sciences, University of Catania, Catania, Italy; 7IRCCS Association Oasi Maria S.S.-Institute for Research on Mental Retardation and Brain Aging, Troina, Enna, ItalyBackground: Folate deficiency is associated with cardiovascular disease, megaloblastic anemia, and with hyperhomocysteinemia. This study has been undertaken to investigate the role of folate status during the progression of the diabetic retinopathy.Methods: We measured the plasma levels of homocysteine, folic acid, and red cell folate in 70 diabetic type 2 patients with nonproliferative diabetic retinopathy (NPDR), 65 with proliferative diabetic retinopathy (PDR), 96 without diabetic retinopathy, and 80 healthy subjects used as a control group.Results: We found higher plasma levels of homocysteine in the NPDR group compared to the control group (P<0.001) and in the PDR group compared to control group (P<0.001) and NPDR group (P<0.01). The severity of diabetic retinopathy was associated with lower folic acid and red cell folate levels, and a significant difference was observed between PDR and NPDR groups (P<0.05).Conclusion: The folate status could play a role in the development and progression of diabetic retinopathy. Keywords: homocysteine, proliferative diabetic retinopathy, nonproliferative diabetic retinopathy, diabetes mellitusMalaguarnera GGagliano CSalomone SGiordano MBucolo CPappalardo ADrago FCaraci FAvitabile TMotta MDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2015, Iss default, Pp 1437-1442 (2015)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Malaguarnera G
Gagliano C
Salomone S
Giordano M
Bucolo C
Pappalardo A
Drago F
Caraci F
Avitabile T
Motta M
Folate status in type 2 diabetic patients with and without retinopathy
description Giulia Malaguarnera,1 Caterina Gagliano,2,3 Salvatore Salomone,1 Maria Giordano,4 Claudio Bucolo,1 Antonino Pappalardo,5 Filippo Drago,1 Filippo Caraci,6,7 Teresio Avitabile,2 Massimo Motta51Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy; 2Department of Ophthalmology, University of Catania, Catania, Italy; 3Neurovisual Science Technology (NEST), Catania, Catania, Italy; 4Gerontology and Bone Metabolic Disease Section, Department of Medical Sciences, University of Turin, Turin; 5Department of Medical and Paediatric Sciences, University of Catania, Italy; 6Department of Drug Sciences, University of Catania, Catania, Italy; 7IRCCS Association Oasi Maria S.S.-Institute for Research on Mental Retardation and Brain Aging, Troina, Enna, ItalyBackground: Folate deficiency is associated with cardiovascular disease, megaloblastic anemia, and with hyperhomocysteinemia. This study has been undertaken to investigate the role of folate status during the progression of the diabetic retinopathy.Methods: We measured the plasma levels of homocysteine, folic acid, and red cell folate in 70 diabetic type 2 patients with nonproliferative diabetic retinopathy (NPDR), 65 with proliferative diabetic retinopathy (PDR), 96 without diabetic retinopathy, and 80 healthy subjects used as a control group.Results: We found higher plasma levels of homocysteine in the NPDR group compared to the control group (P<0.001) and in the PDR group compared to control group (P<0.001) and NPDR group (P<0.01). The severity of diabetic retinopathy was associated with lower folic acid and red cell folate levels, and a significant difference was observed between PDR and NPDR groups (P<0.05).Conclusion: The folate status could play a role in the development and progression of diabetic retinopathy. Keywords: homocysteine, proliferative diabetic retinopathy, nonproliferative diabetic retinopathy, diabetes mellitus
format article
author Malaguarnera G
Gagliano C
Salomone S
Giordano M
Bucolo C
Pappalardo A
Drago F
Caraci F
Avitabile T
Motta M
author_facet Malaguarnera G
Gagliano C
Salomone S
Giordano M
Bucolo C
Pappalardo A
Drago F
Caraci F
Avitabile T
Motta M
author_sort Malaguarnera G
title Folate status in type 2 diabetic patients with and without retinopathy
title_short Folate status in type 2 diabetic patients with and without retinopathy
title_full Folate status in type 2 diabetic patients with and without retinopathy
title_fullStr Folate status in type 2 diabetic patients with and without retinopathy
title_full_unstemmed Folate status in type 2 diabetic patients with and without retinopathy
title_sort folate status in type 2 diabetic patients with and without retinopathy
publisher Dove Medical Press
publishDate 2015
url https://doaj.org/article/939cd3da8b1a4981b663530d10f2ce1f
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AT giordanom folatestatusintype2diabeticpatientswithnbspandwithoutretinopathy
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