Real time and delayed effects of subcortical low intensity focused ultrasound

Abstract Deep brain nuclei are integral components of large-scale circuits mediating important cognitive and sensorimotor functions. However, because they fall outside the domain of conventional non-invasive neuromodulatory techniques, their study has been primarily based on neuropsychological model...

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Autores principales:	Joshua A. Cain, Shakthi Visagan, Micah A. Johnson, Julia Crone, Robin Blades, Norman M. Spivak, David W. Shattuck, Martin M. Monti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/939d29b0393c46829e2aa92ce1db6af4
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spelling	oai:doaj.org-article:939d29b0393c46829e2aa92ce1db6af42021-12-02T13:18:01ZReal time and delayed effects of subcortical low intensity focused ultrasound10.1038/s41598-021-85504-y2045-2322https://doaj.org/article/939d29b0393c46829e2aa92ce1db6af42021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85504-yhttps://doaj.org/toc/2045-2322Abstract Deep brain nuclei are integral components of large-scale circuits mediating important cognitive and sensorimotor functions. However, because they fall outside the domain of conventional non-invasive neuromodulatory techniques, their study has been primarily based on neuropsychological models, limiting the ability to fully characterize their role and to develop interventions in cases where they are damaged. To address this gap, we used the emerging technology of non-invasive low-intensity focused ultrasound (LIFU) to directly modulate left lateralized basal ganglia structures in healthy volunteers. During sonication, we observed local and distal decreases in blood oxygenation level dependent (BOLD) signal in the targeted left globus pallidus (GP) and in large-scale cortical networks. We also observed a generalized decrease in relative perfusion throughout the cerebrum following sonication. These results show, for the first time using functional MRI data, the ability to modulate deep-brain nuclei using LIFU while measuring its local and global consequences, opening the door for future applications of subcortical LIFU.Joshua A. CainShakthi VisaganMicah A. JohnsonJulia CroneRobin BladesNorman M. SpivakDavid W. ShattuckMartin M. MontiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joshua A. Cain Shakthi Visagan Micah A. Johnson Julia Crone Robin Blades Norman M. Spivak David W. Shattuck Martin M. Monti Real time and delayed effects of subcortical low intensity focused ultrasound
description	Abstract Deep brain nuclei are integral components of large-scale circuits mediating important cognitive and sensorimotor functions. However, because they fall outside the domain of conventional non-invasive neuromodulatory techniques, their study has been primarily based on neuropsychological models, limiting the ability to fully characterize their role and to develop interventions in cases where they are damaged. To address this gap, we used the emerging technology of non-invasive low-intensity focused ultrasound (LIFU) to directly modulate left lateralized basal ganglia structures in healthy volunteers. During sonication, we observed local and distal decreases in blood oxygenation level dependent (BOLD) signal in the targeted left globus pallidus (GP) and in large-scale cortical networks. We also observed a generalized decrease in relative perfusion throughout the cerebrum following sonication. These results show, for the first time using functional MRI data, the ability to modulate deep-brain nuclei using LIFU while measuring its local and global consequences, opening the door for future applications of subcortical LIFU.
format	article
author	Joshua A. Cain Shakthi Visagan Micah A. Johnson Julia Crone Robin Blades Norman M. Spivak David W. Shattuck Martin M. Monti
author_facet	Joshua A. Cain Shakthi Visagan Micah A. Johnson Julia Crone Robin Blades Norman M. Spivak David W. Shattuck Martin M. Monti
author_sort	Joshua A. Cain
title	Real time and delayed effects of subcortical low intensity focused ultrasound
title_short	Real time and delayed effects of subcortical low intensity focused ultrasound
title_full	Real time and delayed effects of subcortical low intensity focused ultrasound
title_fullStr	Real time and delayed effects of subcortical low intensity focused ultrasound
title_full_unstemmed	Real time and delayed effects of subcortical low intensity focused ultrasound
title_sort	real time and delayed effects of subcortical low intensity focused ultrasound
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/939d29b0393c46829e2aa92ce1db6af4
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Real time and delayed effects of subcortical low intensity focused ultrasound

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