Enriched environment for offspring improves learning and memory impairments induced by sevoflurane exposure during the second trimester of pregnancy

Studies in animals indicate that sevoflurane exposure in the second trimester of pregnancy has harmful effects on the learning and memory of offspring. Whether an enriched environment can reverse the damage of sevoflurane exposure in the second trimester of pregnancy on the learning and memory of ra...

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Autores principales:	Shao-Wei Yin, Yi-Lin Meng, Chuang Li, Yuan Wang
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2022
Materias:	apoptosis; fetal; learning; memory; neurogenesis; offspring; proliferation; sevoflurane; signal pathway Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/93a03ef13fbe4ef2aa1b440945278547
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spelling	oai:doaj.org-article:93a03ef13fbe4ef2aa1b4409452785472021-11-19T12:16:44ZEnriched environment for offspring improves learning and memory impairments induced by sevoflurane exposure during the second trimester of pregnancy1673-537410.4103/1673-5374.327347https://doaj.org/article/93a03ef13fbe4ef2aa1b4409452785472022-01-01T00:00:00Zhttp://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=6;spage=1293;epage=1298;aulast=Yinhttps://doaj.org/toc/1673-5374Studies in animals indicate that sevoflurane exposure in the second trimester of pregnancy has harmful effects on the learning and memory of offspring. Whether an enriched environment can reverse the damage of sevoflurane exposure in the second trimester of pregnancy on the learning and memory of rat offspring remains unclear. In this study, rats at 14 days of pregnancy were exposed to 3.5% sevoflurane for 2 hours and their offspring were treated with an enriched environment for 20 successive days. We found that the enriched environment for offspring increased nestin and Ki67 levels in hippocampal tissue, increased hippocampal neurogenesis, inhibited glycogen synthase kinase 3β activity, and increased the expression of cell proliferation-related β-catenin and apoptosis-related Bcl-2, indicating that an enriched environment reduces sevoflurane-induced damage by increasing the proliferation of stem cells in the hippocampus. These findings suggest that an enriched environment can reverse the effects of sevoflurane inhaled by rats during the second trimester of pregnancy on learning and memory of offspring. This study was approved by the Animal Ethics Committee of Shengjing Hospital of China Medical University (approval No. 2018PS07K) on January 2, 2018.Shao-Wei YinYi-Lin MengChuang LiYuan WangWolters Kluwer Medknow Publicationsarticleapoptosis; fetal; learning; memory; neurogenesis; offspring; proliferation; sevoflurane; signal pathwayNeurology. Diseases of the nervous systemRC346-429ENNeural Regeneration Research, Vol 17, Iss 6, Pp 1293-1298 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	apoptosis; fetal; learning; memory; neurogenesis; offspring; proliferation; sevoflurane; signal pathway Neurology. Diseases of the nervous system RC346-429
spellingShingle	apoptosis; fetal; learning; memory; neurogenesis; offspring; proliferation; sevoflurane; signal pathway Neurology. Diseases of the nervous system RC346-429 Shao-Wei Yin Yi-Lin Meng Chuang Li Yuan Wang Enriched environment for offspring improves learning and memory impairments induced by sevoflurane exposure during the second trimester of pregnancy
description	Studies in animals indicate that sevoflurane exposure in the second trimester of pregnancy has harmful effects on the learning and memory of offspring. Whether an enriched environment can reverse the damage of sevoflurane exposure in the second trimester of pregnancy on the learning and memory of rat offspring remains unclear. In this study, rats at 14 days of pregnancy were exposed to 3.5% sevoflurane for 2 hours and their offspring were treated with an enriched environment for 20 successive days. We found that the enriched environment for offspring increased nestin and Ki67 levels in hippocampal tissue, increased hippocampal neurogenesis, inhibited glycogen synthase kinase 3β activity, and increased the expression of cell proliferation-related β-catenin and apoptosis-related Bcl-2, indicating that an enriched environment reduces sevoflurane-induced damage by increasing the proliferation of stem cells in the hippocampus. These findings suggest that an enriched environment can reverse the effects of sevoflurane inhaled by rats during the second trimester of pregnancy on learning and memory of offspring. This study was approved by the Animal Ethics Committee of Shengjing Hospital of China Medical University (approval No. 2018PS07K) on January 2, 2018.
format	article
author	Shao-Wei Yin Yi-Lin Meng Chuang Li Yuan Wang
author_facet	Shao-Wei Yin Yi-Lin Meng Chuang Li Yuan Wang
author_sort	Shao-Wei Yin
title	Enriched environment for offspring improves learning and memory impairments induced by sevoflurane exposure during the second trimester of pregnancy
title_short	Enriched environment for offspring improves learning and memory impairments induced by sevoflurane exposure during the second trimester of pregnancy
title_full	Enriched environment for offspring improves learning and memory impairments induced by sevoflurane exposure during the second trimester of pregnancy
title_fullStr	Enriched environment for offspring improves learning and memory impairments induced by sevoflurane exposure during the second trimester of pregnancy
title_full_unstemmed	Enriched environment for offspring improves learning and memory impairments induced by sevoflurane exposure during the second trimester of pregnancy
title_sort	enriched environment for offspring improves learning and memory impairments induced by sevoflurane exposure during the second trimester of pregnancy
publisher	Wolters Kluwer Medknow Publications
publishDate	2022
url	https://doaj.org/article/93a03ef13fbe4ef2aa1b440945278547
work_keys_str_mv	AT shaoweiyin enrichedenvironmentforoffspringimproveslearningandmemoryimpairmentsinducedbysevofluraneexposureduringthesecondtrimesterofpregnancy AT yilinmeng enrichedenvironmentforoffspringimproveslearningandmemoryimpairmentsinducedbysevofluraneexposureduringthesecondtrimesterofpregnancy AT chuangli enrichedenvironmentforoffspringimproveslearningandmemoryimpairmentsinducedbysevofluraneexposureduringthesecondtrimesterofpregnancy AT yuanwang enrichedenvironmentforoffspringimproveslearningandmemoryimpairmentsinducedbysevofluraneexposureduringthesecondtrimesterofpregnancy
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Enriched environment for offspring improves learning and memory impairments induced by sevoflurane exposure during the second trimester of pregnancy

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