Clinical utility of quantitative analysis of bone scintigraphy in detecting clinically active joint and high disease activity in patients with rheumatoid arthritis

Abstract Background The purpose of this study was to investigate the efficiency of quantitative parameters of bone scintigraphy in detecting clinically active joint and high disease activity in patients with rheumatoid arthritis. Methods We retrospectively enrolled 65 patients with rheumatoid arthri...

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Autores principales:	Jeong Won Lee, Sung Hae Chang, Su Jin Jang, Hee Jin Park, Sang Mi Lee, Ki Jin Jung
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Bone scintigraphy Rheumatoid arthritis Joint Quantitative analysis DAS28 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/93a9b179309043b1af6f722fbfc6035b
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spelling	oai:doaj.org-article:93a9b179309043b1af6f722fbfc6035b2021-11-28T12:30:34ZClinical utility of quantitative analysis of bone scintigraphy in detecting clinically active joint and high disease activity in patients with rheumatoid arthritis10.1186/s12880-021-00712-21471-2342https://doaj.org/article/93a9b179309043b1af6f722fbfc6035b2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12880-021-00712-2https://doaj.org/toc/1471-2342Abstract Background The purpose of this study was to investigate the efficiency of quantitative parameters of bone scintigraphy in detecting clinically active joint and high disease activity in patients with rheumatoid arthritis. Methods We retrospectively enrolled 65 patients with rheumatoid arthritis who underwent bone scintigraphy for diagnostic work-up. Quantitative analysis of bone scintigraphy images was conducted using an in-house software, and joint uptake ratio of 28 joints was measured for the calculation of the disease activity score of 28 joints using erythrocyte sedimentation rate (DAS28-ESR). The relationship between joint uptake ratio and clinical findings and the efficiency of joint uptake ratio in detecting clinically active joint and high disease activity were assessed. Results Clinically active joint (tender and/or swollen joints) showed significantly higher joint uptake ratio than did other non-affected joints (p < 0.05). The sensitivity, specificity, positive predictive value, and negative predictive value (NPV) of joint uptake ratio for identifying clinically active joint were 78.7%, 52.0%, 32.9%, and 89.1%, respectively, and those of the summed joint uptake ratio for detecting high disease activity were 92.9%, 66.8%, 43.3%, and 97.1%, respectively; the joint uptake ratio showed high detection ability, especially for active joints of the elbow, wrist, and metacarpo-phalangeal joint areas. The summed joint uptake ratio of 28 joints showed a significantly strong positive correlation with DAS28-ESR (p < 0.001; correlation coefficient, 0.725). Conclusion Quantitative parameters of bone scintigraphy showed high sensitivity and NPV for detecting clinically active joint and high disease activity in patients with rheumatoid arthritis.Jeong Won LeeSung Hae ChangSu Jin JangHee Jin ParkSang Mi LeeKi Jin JungBMCarticleBone scintigraphyRheumatoid arthritisJointQuantitative analysisDAS28Medical technologyR855-855.5ENBMC Medical Imaging, Vol 21, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bone scintigraphy Rheumatoid arthritis Joint Quantitative analysis DAS28 Medical technology R855-855.5
spellingShingle	Bone scintigraphy Rheumatoid arthritis Joint Quantitative analysis DAS28 Medical technology R855-855.5 Jeong Won Lee Sung Hae Chang Su Jin Jang Hee Jin Park Sang Mi Lee Ki Jin Jung Clinical utility of quantitative analysis of bone scintigraphy in detecting clinically active joint and high disease activity in patients with rheumatoid arthritis
description	Abstract Background The purpose of this study was to investigate the efficiency of quantitative parameters of bone scintigraphy in detecting clinically active joint and high disease activity in patients with rheumatoid arthritis. Methods We retrospectively enrolled 65 patients with rheumatoid arthritis who underwent bone scintigraphy for diagnostic work-up. Quantitative analysis of bone scintigraphy images was conducted using an in-house software, and joint uptake ratio of 28 joints was measured for the calculation of the disease activity score of 28 joints using erythrocyte sedimentation rate (DAS28-ESR). The relationship between joint uptake ratio and clinical findings and the efficiency of joint uptake ratio in detecting clinically active joint and high disease activity were assessed. Results Clinically active joint (tender and/or swollen joints) showed significantly higher joint uptake ratio than did other non-affected joints (p < 0.05). The sensitivity, specificity, positive predictive value, and negative predictive value (NPV) of joint uptake ratio for identifying clinically active joint were 78.7%, 52.0%, 32.9%, and 89.1%, respectively, and those of the summed joint uptake ratio for detecting high disease activity were 92.9%, 66.8%, 43.3%, and 97.1%, respectively; the joint uptake ratio showed high detection ability, especially for active joints of the elbow, wrist, and metacarpo-phalangeal joint areas. The summed joint uptake ratio of 28 joints showed a significantly strong positive correlation with DAS28-ESR (p < 0.001; correlation coefficient, 0.725). Conclusion Quantitative parameters of bone scintigraphy showed high sensitivity and NPV for detecting clinically active joint and high disease activity in patients with rheumatoid arthritis.
format	article
author	Jeong Won Lee Sung Hae Chang Su Jin Jang Hee Jin Park Sang Mi Lee Ki Jin Jung
author_facet	Jeong Won Lee Sung Hae Chang Su Jin Jang Hee Jin Park Sang Mi Lee Ki Jin Jung
author_sort	Jeong Won Lee
title	Clinical utility of quantitative analysis of bone scintigraphy in detecting clinically active joint and high disease activity in patients with rheumatoid arthritis
title_short	Clinical utility of quantitative analysis of bone scintigraphy in detecting clinically active joint and high disease activity in patients with rheumatoid arthritis
title_full	Clinical utility of quantitative analysis of bone scintigraphy in detecting clinically active joint and high disease activity in patients with rheumatoid arthritis
title_fullStr	Clinical utility of quantitative analysis of bone scintigraphy in detecting clinically active joint and high disease activity in patients with rheumatoid arthritis
title_full_unstemmed	Clinical utility of quantitative analysis of bone scintigraphy in detecting clinically active joint and high disease activity in patients with rheumatoid arthritis
title_sort	clinical utility of quantitative analysis of bone scintigraphy in detecting clinically active joint and high disease activity in patients with rheumatoid arthritis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/93a9b179309043b1af6f722fbfc6035b
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Clinical utility of quantitative analysis of bone scintigraphy in detecting clinically active joint and high disease activity in patients with rheumatoid arthritis

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