DGUOK-AS1 acts as a tumorpromoter through regulatingmiR-204-5p/IL-11 axis in breast cancer

Breast cancer is one of the most lethal malignancies among women; however, the underlying molecular mechanism involved in the progression and metastasis of breast cancer remains unclear. Numerous studies have confirmed that long noncoding RNAs are abnormally expressed in breast cancer and play cruci...

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Autores principales:	Yiran Liang, Fangzhou Ye, Yajie Wang, Yalun Li, Yaming Li, Xiaojin Song, Dan Luo, Li Long, Dianwen Han, Ying Liu, Zekun Wang, Bing Chen, Wenjing Zhao, Lijuan Wang, Qifeng Yang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	DGUOK-AS1 miR-204-5p IL11 progression breast cancer Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/93b03bdbefbf46f6b1b4decc967c3719
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spelling	oai:doaj.org-article:93b03bdbefbf46f6b1b4decc967c37192021-11-04T04:28:44ZDGUOK-AS1 acts as a tumorpromoter through regulatingmiR-204-5p/IL-11 axis in breast cancer2162-253110.1016/j.omtn.2021.10.018https://doaj.org/article/93b03bdbefbf46f6b1b4decc967c37192021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2162253121002614https://doaj.org/toc/2162-2531Breast cancer is one of the most lethal malignancies among women; however, the underlying molecular mechanism involved in the progression and metastasis of breast cancer remains unclear. Numerous studies have confirmed that long noncoding RNAs are abnormally expressed in breast cancer and play crucial roles in cell proliferation and metastasis. In the study, we evaluated the functional role and detailed mechanism of DGUOK-AS1 in breast cancer progression and metastasis. DGUOK-AS1 knockdown suppressed proliferation, migration, and invasion of breast cancer cells in vitro and in vivo. Mechanistically, miR-204-5p was identified as an inhibitory target of DGUOK-AS1, which served as a tumor suppressor in breast cancer. Significantly, we found that the ectopic expression of miR-204-5p could counteract DGUOK-AS1-mediated promotion of cell proliferation and metastasis in breast cancer. Moreover, IL-11 was found to be the downstream target of miR-204-5p, and DGUOK-AS1 could protect IL-11 from miR-204-5p-mediated degradation. DGUOK-AS1 overexpression promoted breast cancer cell migration, angiogenesis, and macrophage migration, mediating by the increased secretion of IL-11, which was extremely important for cancer progression. Collectively, our studies reveal that DGUOK-AS1/miR-204-5p/IL-11 axis plays a significant role in the progression and metastasis of breast cancer, and DGUOK-AS1 might be a novel biomarker and therapeutic target for breast cancer.Yiran LiangFangzhou YeYajie WangYalun LiYaming LiXiaojin SongDan LuoLi LongDianwen HanYing LiuZekun WangBing ChenWenjing ZhaoLijuan WangQifeng YangElsevierarticleDGUOK-AS1miR-204-5pIL11progressionbreast cancerTherapeutics. PharmacologyRM1-950ENMolecular Therapy: Nucleic Acids, Vol 26, Iss , Pp 1079-1091 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	DGUOK-AS1 miR-204-5p IL11 progression breast cancer Therapeutics. Pharmacology RM1-950
spellingShingle	DGUOK-AS1 miR-204-5p IL11 progression breast cancer Therapeutics. Pharmacology RM1-950 Yiran Liang Fangzhou Ye Yajie Wang Yalun Li Yaming Li Xiaojin Song Dan Luo Li Long Dianwen Han Ying Liu Zekun Wang Bing Chen Wenjing Zhao Lijuan Wang Qifeng Yang DGUOK-AS1 acts as a tumorpromoter through regulatingmiR-204-5p/IL-11 axis in breast cancer
description	Breast cancer is one of the most lethal malignancies among women; however, the underlying molecular mechanism involved in the progression and metastasis of breast cancer remains unclear. Numerous studies have confirmed that long noncoding RNAs are abnormally expressed in breast cancer and play crucial roles in cell proliferation and metastasis. In the study, we evaluated the functional role and detailed mechanism of DGUOK-AS1 in breast cancer progression and metastasis. DGUOK-AS1 knockdown suppressed proliferation, migration, and invasion of breast cancer cells in vitro and in vivo. Mechanistically, miR-204-5p was identified as an inhibitory target of DGUOK-AS1, which served as a tumor suppressor in breast cancer. Significantly, we found that the ectopic expression of miR-204-5p could counteract DGUOK-AS1-mediated promotion of cell proliferation and metastasis in breast cancer. Moreover, IL-11 was found to be the downstream target of miR-204-5p, and DGUOK-AS1 could protect IL-11 from miR-204-5p-mediated degradation. DGUOK-AS1 overexpression promoted breast cancer cell migration, angiogenesis, and macrophage migration, mediating by the increased secretion of IL-11, which was extremely important for cancer progression. Collectively, our studies reveal that DGUOK-AS1/miR-204-5p/IL-11 axis plays a significant role in the progression and metastasis of breast cancer, and DGUOK-AS1 might be a novel biomarker and therapeutic target for breast cancer.
format	article
author	Yiran Liang Fangzhou Ye Yajie Wang Yalun Li Yaming Li Xiaojin Song Dan Luo Li Long Dianwen Han Ying Liu Zekun Wang Bing Chen Wenjing Zhao Lijuan Wang Qifeng Yang
author_facet	Yiran Liang Fangzhou Ye Yajie Wang Yalun Li Yaming Li Xiaojin Song Dan Luo Li Long Dianwen Han Ying Liu Zekun Wang Bing Chen Wenjing Zhao Lijuan Wang Qifeng Yang
author_sort	Yiran Liang
title	DGUOK-AS1 acts as a tumorpromoter through regulatingmiR-204-5p/IL-11 axis in breast cancer
title_short	DGUOK-AS1 acts as a tumorpromoter through regulatingmiR-204-5p/IL-11 axis in breast cancer
title_full	DGUOK-AS1 acts as a tumorpromoter through regulatingmiR-204-5p/IL-11 axis in breast cancer
title_fullStr	DGUOK-AS1 acts as a tumorpromoter through regulatingmiR-204-5p/IL-11 axis in breast cancer
title_full_unstemmed	DGUOK-AS1 acts as a tumorpromoter through regulatingmiR-204-5p/IL-11 axis in breast cancer
title_sort	dguok-as1 acts as a tumorpromoter through regulatingmir-204-5p/il-11 axis in breast cancer
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/93b03bdbefbf46f6b1b4decc967c3719
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DGUOK-AS1 acts as a tumorpromoter through regulatingmiR-204-5p/IL-11 axis in breast cancer

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