A translational program that suppresses metabolism to shield the genome

Translatome remodelling controls stress-adaptive protein output. Here the authors reveal that in response to stimuli, eIF5A functions as a pH-regulated translation factor that responds to fermentation-induced acidosis affecting cellular metabolism.

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Autores principales:	Nathan C. Balukoff, J. J. David Ho, Phaedra R. Theodoridis, Miling Wang, Michael Bokros, Lis M. Llanio, Jonathan R. Krieger, Jonathan H. Schatz, Stephen Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/93b48d789e3e4b9d8f527f9c594d44a2
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spelling	oai:doaj.org-article:93b48d789e3e4b9d8f527f9c594d44a22021-12-02T14:40:50ZA translational program that suppresses metabolism to shield the genome10.1038/s41467-020-19602-22041-1723https://doaj.org/article/93b48d789e3e4b9d8f527f9c594d44a22020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19602-2https://doaj.org/toc/2041-1723Translatome remodelling controls stress-adaptive protein output. Here the authors reveal that in response to stimuli, eIF5A functions as a pH-regulated translation factor that responds to fermentation-induced acidosis affecting cellular metabolism.Nathan C. BalukoffJ. J. David HoPhaedra R. TheodoridisMiling WangMichael BokrosLis M. LlanioJonathan R. KriegerJonathan H. SchatzStephen LeeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nathan C. Balukoff J. J. David Ho Phaedra R. Theodoridis Miling Wang Michael Bokros Lis M. Llanio Jonathan R. Krieger Jonathan H. Schatz Stephen Lee A translational program that suppresses metabolism to shield the genome
description	Translatome remodelling controls stress-adaptive protein output. Here the authors reveal that in response to stimuli, eIF5A functions as a pH-regulated translation factor that responds to fermentation-induced acidosis affecting cellular metabolism.
format	article
author	Nathan C. Balukoff J. J. David Ho Phaedra R. Theodoridis Miling Wang Michael Bokros Lis M. Llanio Jonathan R. Krieger Jonathan H. Schatz Stephen Lee
author_facet	Nathan C. Balukoff J. J. David Ho Phaedra R. Theodoridis Miling Wang Michael Bokros Lis M. Llanio Jonathan R. Krieger Jonathan H. Schatz Stephen Lee
author_sort	Nathan C. Balukoff
title	A translational program that suppresses metabolism to shield the genome
title_short	A translational program that suppresses metabolism to shield the genome
title_full	A translational program that suppresses metabolism to shield the genome
title_fullStr	A translational program that suppresses metabolism to shield the genome
title_full_unstemmed	A translational program that suppresses metabolism to shield the genome
title_sort	translational program that suppresses metabolism to shield the genome
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/93b48d789e3e4b9d8f527f9c594d44a2
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A translational program that suppresses metabolism to shield the genome

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