Chemodivergent manganese-catalyzed C–H activation: modular synthesis of fluorogenic probes

Bioorthogonal diversification of peptides is generally dependent on impractical prefunctionalization methods. Here, the authors develop a manganese(I)-catalyzed C–H fluorescent labeling with BODIPY probes, which enables the development of activatable fluorophores to image cell function.

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Autores principales: Nikolaos Kaplaneris, Jongwoo Son, Lorena Mendive-Tapia, Adelina Kopp, Nicole D. Barth, Isaac Maksso, Marc Vendrell, Lutz Ackermann
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/93b52903be4747fead66811972b504c1
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spelling oai:doaj.org-article:93b52903be4747fead66811972b504c12021-12-02T17:47:02ZChemodivergent manganese-catalyzed C–H activation: modular synthesis of fluorogenic probes10.1038/s41467-021-23462-92041-1723https://doaj.org/article/93b52903be4747fead66811972b504c12021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23462-9https://doaj.org/toc/2041-1723Bioorthogonal diversification of peptides is generally dependent on impractical prefunctionalization methods. Here, the authors develop a manganese(I)-catalyzed C–H fluorescent labeling with BODIPY probes, which enables the development of activatable fluorophores to image cell function.Nikolaos KaplanerisJongwoo SonLorena Mendive-TapiaAdelina KoppNicole D. BarthIsaac MakssoMarc VendrellLutz AckermannNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Nikolaos Kaplaneris
Jongwoo Son
Lorena Mendive-Tapia
Adelina Kopp
Nicole D. Barth
Isaac Maksso
Marc Vendrell
Lutz Ackermann
Chemodivergent manganese-catalyzed C–H activation: modular synthesis of fluorogenic probes
description Bioorthogonal diversification of peptides is generally dependent on impractical prefunctionalization methods. Here, the authors develop a manganese(I)-catalyzed C–H fluorescent labeling with BODIPY probes, which enables the development of activatable fluorophores to image cell function.
format article
author Nikolaos Kaplaneris
Jongwoo Son
Lorena Mendive-Tapia
Adelina Kopp
Nicole D. Barth
Isaac Maksso
Marc Vendrell
Lutz Ackermann
author_facet Nikolaos Kaplaneris
Jongwoo Son
Lorena Mendive-Tapia
Adelina Kopp
Nicole D. Barth
Isaac Maksso
Marc Vendrell
Lutz Ackermann
author_sort Nikolaos Kaplaneris
title Chemodivergent manganese-catalyzed C–H activation: modular synthesis of fluorogenic probes
title_short Chemodivergent manganese-catalyzed C–H activation: modular synthesis of fluorogenic probes
title_full Chemodivergent manganese-catalyzed C–H activation: modular synthesis of fluorogenic probes
title_fullStr Chemodivergent manganese-catalyzed C–H activation: modular synthesis of fluorogenic probes
title_full_unstemmed Chemodivergent manganese-catalyzed C–H activation: modular synthesis of fluorogenic probes
title_sort chemodivergent manganese-catalyzed c–h activation: modular synthesis of fluorogenic probes
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/93b52903be4747fead66811972b504c1
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