Younger age of onset and uveitis associated with HLA-B27 and delayed diagnosis in Thai patients with axial spondyloarthritis

Abstract To identify characteristics associated with HLA-B27, and to identify factors associated with delayed diagnosis in Thai patients with axial spondyloarthritis (axSpA). This cross-sectional study included Thai patients were diagnosed with axSpA by a rheumatologist at Siriraj Hospital. Clinical...

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Autores principales:	Naphruet Limsakul, Praveena Chiowchanwisawakit, Parichart Permpikul, Yubolrat Thanaketpaisarn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/93be8979ea0341d99e7bb13edf20d3a0
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spelling	oai:doaj.org-article:93be8979ea0341d99e7bb13edf20d3a02021-12-02T16:10:36ZYounger age of onset and uveitis associated with HLA-B27 and delayed diagnosis in Thai patients with axial spondyloarthritis10.1038/s41598-021-93001-52045-2322https://doaj.org/article/93be8979ea0341d99e7bb13edf20d3a02021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93001-5https://doaj.org/toc/2045-2322Abstract To identify characteristics associated with HLA-B27, and to identify factors associated with delayed diagnosis in Thai patients with axial spondyloarthritis (axSpA). This cross-sectional study included Thai patients were diagnosed with axSpA by a rheumatologist at Siriraj Hospital. Clinical data were collected. Regression analyses were employed to identify factors associated with study outcomes. Of total 177 patients, 127 (72%) were positive HLA-B27. Uveitis [Odds ratio (OR) 4.0], age at onset of the first musculoskeletal symptom of ≤ 28 years [OR 3.5], female [OR 0.4], and psoriasis [OR 0.4] were significantly associated with HLA-B27 in multiple regression analysis. Those with positive HLA-B27 had less spinal flexibility. Elevated C-reactive protein (p = 0.012) was associated with shorter delay in diagnosis, while uveitis (p < 0.001) and younger age at onset of the first symptom (p = 0.002) were associated with longer delay in diagnosis in multiple regression analysis. Younger age at onset of the first musculoskeletal symptom and uveitis were associated with HLA-B27 and delayed diagnosis in axSpA patients. Young people with musculoskeletal symptom and uveitis should be referred to a rheumatologist to rule out or make a timely diagnosis of axSpA.Naphruet LimsakulPraveena ChiowchanwisawakitParichart PermpikulYubolrat ThanaketpaisarnNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Naphruet Limsakul Praveena Chiowchanwisawakit Parichart Permpikul Yubolrat Thanaketpaisarn Younger age of onset and uveitis associated with HLA-B27 and delayed diagnosis in Thai patients with axial spondyloarthritis
description	Abstract To identify characteristics associated with HLA-B27, and to identify factors associated with delayed diagnosis in Thai patients with axial spondyloarthritis (axSpA). This cross-sectional study included Thai patients were diagnosed with axSpA by a rheumatologist at Siriraj Hospital. Clinical data were collected. Regression analyses were employed to identify factors associated with study outcomes. Of total 177 patients, 127 (72%) were positive HLA-B27. Uveitis [Odds ratio (OR) 4.0], age at onset of the first musculoskeletal symptom of ≤ 28 years [OR 3.5], female [OR 0.4], and psoriasis [OR 0.4] were significantly associated with HLA-B27 in multiple regression analysis. Those with positive HLA-B27 had less spinal flexibility. Elevated C-reactive protein (p = 0.012) was associated with shorter delay in diagnosis, while uveitis (p < 0.001) and younger age at onset of the first symptom (p = 0.002) were associated with longer delay in diagnosis in multiple regression analysis. Younger age at onset of the first musculoskeletal symptom and uveitis were associated with HLA-B27 and delayed diagnosis in axSpA patients. Young people with musculoskeletal symptom and uveitis should be referred to a rheumatologist to rule out or make a timely diagnosis of axSpA.
format	article
author	Naphruet Limsakul Praveena Chiowchanwisawakit Parichart Permpikul Yubolrat Thanaketpaisarn
author_facet	Naphruet Limsakul Praveena Chiowchanwisawakit Parichart Permpikul Yubolrat Thanaketpaisarn
author_sort	Naphruet Limsakul
title	Younger age of onset and uveitis associated with HLA-B27 and delayed diagnosis in Thai patients with axial spondyloarthritis
title_short	Younger age of onset and uveitis associated with HLA-B27 and delayed diagnosis in Thai patients with axial spondyloarthritis
title_full	Younger age of onset and uveitis associated with HLA-B27 and delayed diagnosis in Thai patients with axial spondyloarthritis
title_fullStr	Younger age of onset and uveitis associated with HLA-B27 and delayed diagnosis in Thai patients with axial spondyloarthritis
title_full_unstemmed	Younger age of onset and uveitis associated with HLA-B27 and delayed diagnosis in Thai patients with axial spondyloarthritis
title_sort	younger age of onset and uveitis associated with hla-b27 and delayed diagnosis in thai patients with axial spondyloarthritis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/93be8979ea0341d99e7bb13edf20d3a0
work_keys_str_mv	AT naphruetlimsakul youngerageofonsetanduveitisassociatedwithhlab27anddelayeddiagnosisinthaipatientswithaxialspondyloarthritis AT praveenachiowchanwisawakit youngerageofonsetanduveitisassociatedwithhlab27anddelayeddiagnosisinthaipatientswithaxialspondyloarthritis AT parichartpermpikul youngerageofonsetanduveitisassociatedwithhlab27anddelayeddiagnosisinthaipatientswithaxialspondyloarthritis AT yubolratthanaketpaisarn youngerageofonsetanduveitisassociatedwithhlab27anddelayeddiagnosisinthaipatientswithaxialspondyloarthritis
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Younger age of onset and uveitis associated with HLA-B27 and delayed diagnosis in Thai patients with axial spondyloarthritis

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