Basement membrane damage by ROS- and JNK-mediated Mmp2 activation drives macrophage recruitment to overgrown tissue

The molecular mechanisms regulating macrophage recruitment to tumors are unclear. Here, the authors use a Drosophila overgrowth model to show how damaged basement membranes recruit macrophages to undead tissue, via an interdependent effect of reactive oxygen species and matrix metalloproteinase 2.

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Auteurs principaux:	Neha Diwanji, Andreas Bergmann
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/93c2f6af999545048616780f10a3bd53
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spelling	oai:doaj.org-article:93c2f6af999545048616780f10a3bd532021-12-02T17:55:10ZBasement membrane damage by ROS- and JNK-mediated Mmp2 activation drives macrophage recruitment to overgrown tissue10.1038/s41467-020-17399-82041-1723https://doaj.org/article/93c2f6af999545048616780f10a3bd532020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17399-8https://doaj.org/toc/2041-1723The molecular mechanisms regulating macrophage recruitment to tumors are unclear. Here, the authors use a Drosophila overgrowth model to show how damaged basement membranes recruit macrophages to undead tissue, via an interdependent effect of reactive oxygen species and matrix metalloproteinase 2.Neha DiwanjiAndreas BergmannNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Neha Diwanji Andreas Bergmann Basement membrane damage by ROS- and JNK-mediated Mmp2 activation drives macrophage recruitment to overgrown tissue
description	The molecular mechanisms regulating macrophage recruitment to tumors are unclear. Here, the authors use a Drosophila overgrowth model to show how damaged basement membranes recruit macrophages to undead tissue, via an interdependent effect of reactive oxygen species and matrix metalloproteinase 2.
format	article
author	Neha Diwanji Andreas Bergmann
author_facet	Neha Diwanji Andreas Bergmann
author_sort	Neha Diwanji
title	Basement membrane damage by ROS- and JNK-mediated Mmp2 activation drives macrophage recruitment to overgrown tissue
title_short	Basement membrane damage by ROS- and JNK-mediated Mmp2 activation drives macrophage recruitment to overgrown tissue
title_full	Basement membrane damage by ROS- and JNK-mediated Mmp2 activation drives macrophage recruitment to overgrown tissue
title_fullStr	Basement membrane damage by ROS- and JNK-mediated Mmp2 activation drives macrophage recruitment to overgrown tissue
title_full_unstemmed	Basement membrane damage by ROS- and JNK-mediated Mmp2 activation drives macrophage recruitment to overgrown tissue
title_sort	basement membrane damage by ros- and jnk-mediated mmp2 activation drives macrophage recruitment to overgrown tissue
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/93c2f6af999545048616780f10a3bd53
work_keys_str_mv	AT nehadiwanji basementmembranedamagebyrosandjnkmediatedmmp2activationdrivesmacrophagerecruitmenttoovergrowntissue AT andreasbergmann basementmembranedamagebyrosandjnkmediatedmmp2activationdrivesmacrophagerecruitmenttoovergrowntissue
_version_	1718379122706612224

Basement membrane damage by ROS- and JNK-mediated Mmp2 activation drives macrophage recruitment to overgrown tissue

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