Basement membrane damage by ROS- and JNK-mediated Mmp2 activation drives macrophage recruitment to overgrown tissue

The molecular mechanisms regulating macrophage recruitment to tumors are unclear. Here, the authors use a Drosophila overgrowth model to show how damaged basement membranes recruit macrophages to undead tissue, via an interdependent effect of reactive oxygen species and matrix metalloproteinase 2.

Guardado en:
Detalles Bibliográficos
Autores principales: Neha Diwanji, Andreas Bergmann
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Q
Acceso en línea:https://doaj.org/article/93c2f6af999545048616780f10a3bd53
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:93c2f6af999545048616780f10a3bd53
record_format dspace
spelling oai:doaj.org-article:93c2f6af999545048616780f10a3bd532021-12-02T17:55:10ZBasement membrane damage by ROS- and JNK-mediated Mmp2 activation drives macrophage recruitment to overgrown tissue10.1038/s41467-020-17399-82041-1723https://doaj.org/article/93c2f6af999545048616780f10a3bd532020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17399-8https://doaj.org/toc/2041-1723The molecular mechanisms regulating macrophage recruitment to tumors are unclear. Here, the authors use a Drosophila overgrowth model to show how damaged basement membranes recruit macrophages to undead tissue, via an interdependent effect of reactive oxygen species and matrix metalloproteinase 2.Neha DiwanjiAndreas BergmannNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Neha Diwanji
Andreas Bergmann
Basement membrane damage by ROS- and JNK-mediated Mmp2 activation drives macrophage recruitment to overgrown tissue
description The molecular mechanisms regulating macrophage recruitment to tumors are unclear. Here, the authors use a Drosophila overgrowth model to show how damaged basement membranes recruit macrophages to undead tissue, via an interdependent effect of reactive oxygen species and matrix metalloproteinase 2.
format article
author Neha Diwanji
Andreas Bergmann
author_facet Neha Diwanji
Andreas Bergmann
author_sort Neha Diwanji
title Basement membrane damage by ROS- and JNK-mediated Mmp2 activation drives macrophage recruitment to overgrown tissue
title_short Basement membrane damage by ROS- and JNK-mediated Mmp2 activation drives macrophage recruitment to overgrown tissue
title_full Basement membrane damage by ROS- and JNK-mediated Mmp2 activation drives macrophage recruitment to overgrown tissue
title_fullStr Basement membrane damage by ROS- and JNK-mediated Mmp2 activation drives macrophage recruitment to overgrown tissue
title_full_unstemmed Basement membrane damage by ROS- and JNK-mediated Mmp2 activation drives macrophage recruitment to overgrown tissue
title_sort basement membrane damage by ros- and jnk-mediated mmp2 activation drives macrophage recruitment to overgrown tissue
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/93c2f6af999545048616780f10a3bd53
work_keys_str_mv AT nehadiwanji basementmembranedamagebyrosandjnkmediatedmmp2activationdrivesmacrophagerecruitmenttoovergrowntissue
AT andreasbergmann basementmembranedamagebyrosandjnkmediatedmmp2activationdrivesmacrophagerecruitmenttoovergrowntissue
_version_ 1718379122706612224