K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling

BRAF drives MEK/ERK activation to facilitate tumorigenesis. Here, the authors show that in response to pro-inflammatory cytokines, ITCH mediates a non-proteolytic ubiquitination and activation of BRAF, which in turn sustains MEK/ERK signaling to facilitate melanoma cell growth.

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Autores principales:	Qing Yin, Tao Han, Bin Fang, Guolin Zhang, Chao Zhang, Evan R. Roberts, Victoria Izumi, Mengmeng Zheng, Shulong Jiang, Xiu Yin, Minjung Kim, Jianfeng Cai, Eric B. Haura, John M. Koomen, Keiran S. M. Smalley, Lixin Wan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/93c520999b9f45c68aaee7bea2c8f9cf
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spelling	oai:doaj.org-article:93c520999b9f45c68aaee7bea2c8f9cf2021-12-02T17:02:09ZK27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling10.1038/s41467-019-09844-02041-1723https://doaj.org/article/93c520999b9f45c68aaee7bea2c8f9cf2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09844-0https://doaj.org/toc/2041-1723BRAF drives MEK/ERK activation to facilitate tumorigenesis. Here, the authors show that in response to pro-inflammatory cytokines, ITCH mediates a non-proteolytic ubiquitination and activation of BRAF, which in turn sustains MEK/ERK signaling to facilitate melanoma cell growth.Qing YinTao HanBin FangGuolin ZhangChao ZhangEvan R. RobertsVictoria IzumiMengmeng ZhengShulong JiangXiu YinMinjung KimJianfeng CaiEric B. HauraJohn M. KoomenKeiran S. M. SmalleyLixin WanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qing Yin Tao Han Bin Fang Guolin Zhang Chao Zhang Evan R. Roberts Victoria Izumi Mengmeng Zheng Shulong Jiang Xiu Yin Minjung Kim Jianfeng Cai Eric B. Haura John M. Koomen Keiran S. M. Smalley Lixin Wan K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling
description	BRAF drives MEK/ERK activation to facilitate tumorigenesis. Here, the authors show that in response to pro-inflammatory cytokines, ITCH mediates a non-proteolytic ubiquitination and activation of BRAF, which in turn sustains MEK/ERK signaling to facilitate melanoma cell growth.
format	article
author	Qing Yin Tao Han Bin Fang Guolin Zhang Chao Zhang Evan R. Roberts Victoria Izumi Mengmeng Zheng Shulong Jiang Xiu Yin Minjung Kim Jianfeng Cai Eric B. Haura John M. Koomen Keiran S. M. Smalley Lixin Wan
author_facet	Qing Yin Tao Han Bin Fang Guolin Zhang Chao Zhang Evan R. Roberts Victoria Izumi Mengmeng Zheng Shulong Jiang Xiu Yin Minjung Kim Jianfeng Cai Eric B. Haura John M. Koomen Keiran S. M. Smalley Lixin Wan
author_sort	Qing Yin
title	K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling
title_short	K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling
title_full	K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling
title_fullStr	K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling
title_full_unstemmed	K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling
title_sort	k27-linked ubiquitination of braf by itch engages cytokine response to maintain mek-erk signaling
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/93c520999b9f45c68aaee7bea2c8f9cf
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K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling

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