Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state

Neutralizing antibodies for respiratory syncytial virus (RSV) can reduce disease in hospitalized children, but current options show limited efficacy. Here, the authors isolate potent single-domain antibodies from llamas that recognize the prefusion conformation of RSV F and prevent RSV replication i...

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Autores principales:	Iebe Rossey, Morgan S. A. Gilman, Stephanie C. Kabeche, Koen Sedeyn, Daniel Wrapp, Masaru Kanekiyo, Man Chen, Vicente Mas, Jan Spitaels, José A. Melero, Barney S. Graham, Bert Schepens, Jason S. McLellan, Xavier Saelens
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/93c63b0a60fe4bb4a99ee0b83523552a
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spelling	oai:doaj.org-article:93c63b0a60fe4bb4a99ee0b83523552a2021-12-02T14:41:19ZPotent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state10.1038/ncomms141582041-1723https://doaj.org/article/93c63b0a60fe4bb4a99ee0b83523552a2017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14158https://doaj.org/toc/2041-1723Neutralizing antibodies for respiratory syncytial virus (RSV) can reduce disease in hospitalized children, but current options show limited efficacy. Here, the authors isolate potent single-domain antibodies from llamas that recognize the prefusion conformation of RSV F and prevent RSV replication in mice.Iebe RosseyMorgan S. A. GilmanStephanie C. KabecheKoen SedeynDaniel WrappMasaru KanekiyoMan ChenVicente MasJan SpitaelsJosé A. MeleroBarney S. GrahamBert SchepensJason S. McLellanXavier SaelensNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Iebe Rossey Morgan S. A. Gilman Stephanie C. Kabeche Koen Sedeyn Daniel Wrapp Masaru Kanekiyo Man Chen Vicente Mas Jan Spitaels José A. Melero Barney S. Graham Bert Schepens Jason S. McLellan Xavier Saelens Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state
description	Neutralizing antibodies for respiratory syncytial virus (RSV) can reduce disease in hospitalized children, but current options show limited efficacy. Here, the authors isolate potent single-domain antibodies from llamas that recognize the prefusion conformation of RSV F and prevent RSV replication in mice.
format	article
author	Iebe Rossey Morgan S. A. Gilman Stephanie C. Kabeche Koen Sedeyn Daniel Wrapp Masaru Kanekiyo Man Chen Vicente Mas Jan Spitaels José A. Melero Barney S. Graham Bert Schepens Jason S. McLellan Xavier Saelens
author_facet	Iebe Rossey Morgan S. A. Gilman Stephanie C. Kabeche Koen Sedeyn Daniel Wrapp Masaru Kanekiyo Man Chen Vicente Mas Jan Spitaels José A. Melero Barney S. Graham Bert Schepens Jason S. McLellan Xavier Saelens
author_sort	Iebe Rossey
title	Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state
title_short	Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state
title_full	Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state
title_fullStr	Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state
title_full_unstemmed	Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state
title_sort	potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/93c63b0a60fe4bb4a99ee0b83523552a
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Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state

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