Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia

ATM and TP53 mutations are associated with poor prognosis in chronic lymphocytic leukaemia (CLL). Here the authors generate mouse models of Tp53- and Atm-defective CLL mimicking the high-risk form of human disease and show that Atm-deficient CLL is sensitive to PARP1 inhibition.

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Autores principales:	Gero Knittel, Tim Rehkämper, Darya Korovkina, Paul Liedgens, Christian Fritz, Alessandro Torgovnick, Yussor Al-Baldawi, Mona Al-Maarri, Yupeng Cun, Oleg Fedorchenko, Arina Riabinska, Filippo Beleggia, Phuong-Hien Nguyen, F. Thomas Wunderlich, Monika Ortmann, Manuel Montesinos-Rongen, Eugen Tausch, Stephan Stilgenbauer, Lukas P. Frenzel, Marco Herling, Carmen Herling, Jasmin Bahlo, Michael Hallek, Martin Peifer, Reinhard Buettner, Thorsten Persigehl, H. Christian Reinhardt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/93c8b6674f2b4c01a38589c9951b35af
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spelling	oai:doaj.org-article:93c8b6674f2b4c01a38589c9951b35af2021-12-02T13:24:23ZTwo mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia10.1038/s41467-017-00210-62041-1723https://doaj.org/article/93c8b6674f2b4c01a38589c9951b35af2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00210-6https://doaj.org/toc/2041-1723ATM and TP53 mutations are associated with poor prognosis in chronic lymphocytic leukaemia (CLL). Here the authors generate mouse models of Tp53- and Atm-defective CLL mimicking the high-risk form of human disease and show that Atm-deficient CLL is sensitive to PARP1 inhibition.Gero KnittelTim RehkämperDarya KorovkinaPaul LiedgensChristian FritzAlessandro TorgovnickYussor Al-BaldawiMona Al-MaarriYupeng CunOleg FedorchenkoArina RiabinskaFilippo BeleggiaPhuong-Hien NguyenF. Thomas WunderlichMonika OrtmannManuel Montesinos-RongenEugen TauschStephan StilgenbauerLukas P. FrenzelMarco HerlingCarmen HerlingJasmin BahloMichael HallekMartin PeiferReinhard BuettnerThorsten PersigehlH. Christian ReinhardtNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gero Knittel Tim Rehkämper Darya Korovkina Paul Liedgens Christian Fritz Alessandro Torgovnick Yussor Al-Baldawi Mona Al-Maarri Yupeng Cun Oleg Fedorchenko Arina Riabinska Filippo Beleggia Phuong-Hien Nguyen F. Thomas Wunderlich Monika Ortmann Manuel Montesinos-Rongen Eugen Tausch Stephan Stilgenbauer Lukas P. Frenzel Marco Herling Carmen Herling Jasmin Bahlo Michael Hallek Martin Peifer Reinhard Buettner Thorsten Persigehl H. Christian Reinhardt Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia
description	ATM and TP53 mutations are associated with poor prognosis in chronic lymphocytic leukaemia (CLL). Here the authors generate mouse models of Tp53- and Atm-defective CLL mimicking the high-risk form of human disease and show that Atm-deficient CLL is sensitive to PARP1 inhibition.
format	article
author	Gero Knittel Tim Rehkämper Darya Korovkina Paul Liedgens Christian Fritz Alessandro Torgovnick Yussor Al-Baldawi Mona Al-Maarri Yupeng Cun Oleg Fedorchenko Arina Riabinska Filippo Beleggia Phuong-Hien Nguyen F. Thomas Wunderlich Monika Ortmann Manuel Montesinos-Rongen Eugen Tausch Stephan Stilgenbauer Lukas P. Frenzel Marco Herling Carmen Herling Jasmin Bahlo Michael Hallek Martin Peifer Reinhard Buettner Thorsten Persigehl H. Christian Reinhardt
author_facet	Gero Knittel Tim Rehkämper Darya Korovkina Paul Liedgens Christian Fritz Alessandro Torgovnick Yussor Al-Baldawi Mona Al-Maarri Yupeng Cun Oleg Fedorchenko Arina Riabinska Filippo Beleggia Phuong-Hien Nguyen F. Thomas Wunderlich Monika Ortmann Manuel Montesinos-Rongen Eugen Tausch Stephan Stilgenbauer Lukas P. Frenzel Marco Herling Carmen Herling Jasmin Bahlo Michael Hallek Martin Peifer Reinhard Buettner Thorsten Persigehl H. Christian Reinhardt
author_sort	Gero Knittel
title	Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia
title_short	Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia
title_full	Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia
title_fullStr	Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia
title_full_unstemmed	Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia
title_sort	two mouse models reveal an actionable parp1 dependence in aggressive chronic lymphocytic leukemia
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/93c8b6674f2b4c01a38589c9951b35af
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Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia

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