Effect of perioperative bronchodilator therapy on postoperative pulmonary function among lung cancer patients with COPD

Abstract Chronic obstructive pulmonary disease (COPD), an established risk factor for lung cancer, remains largely undiagnosed and untreated before lung cancer surgery. We evaluated the effect of perioperative bronchodilator therapy on lung function changes in COPD patients who underwent surgery for...

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Autores principales:	Sun Hye Shin, Sumin Shin, Yunjoo Im, Genehee Lee, Byeong-Ho Jeong, Kyungjong Lee, Sang-Won Um, Hojoong Kim, O. Jung Kwon, Jong Ho Cho, Hong Kwan Kim, Yong Soo Choi, Jhingook Kim, Jae Ill Zo, Young Mog Shim, Juhee Cho, Danbee Kang, Hye Yun Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/93c9c6bf2bf4422dad437790b3874dfa
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spelling	oai:doaj.org-article:93c9c6bf2bf4422dad437790b3874dfa2021-12-02T15:51:12ZEffect of perioperative bronchodilator therapy on postoperative pulmonary function among lung cancer patients with COPD10.1038/s41598-021-86791-12045-2322https://doaj.org/article/93c9c6bf2bf4422dad437790b3874dfa2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86791-1https://doaj.org/toc/2045-2322Abstract Chronic obstructive pulmonary disease (COPD), an established risk factor for lung cancer, remains largely undiagnosed and untreated before lung cancer surgery. We evaluated the effect of perioperative bronchodilator therapy on lung function changes in COPD patients who underwent surgery for non-small cell lung cancer (NSCLC). From a database including NSCLC patients undergoing lung resection, COPD patients were identified and divided into two groups based on the use of bronchodilator during the pre- and post-operative period. Changes in forced expiratory volume in 1 s (FEV1) and postoperative complications were compared between patients treated with and without bronchodilators. Among 268 COPD patients, 112 (41.8%) received perioperative bronchodilator, and 75% (84/112) were newly diagnosed with COPD before surgery. Declines in FEV1 after surgery were alleviated by perioperative bronchodilator even after adjustments for related confounding factors including surgical extent, surgical approach and preoperative FEV1 (adjusted mean difference in FEV1 decline [95% CI] between perioperative bronchodilator group and no perioperative bronchodilator group; − 161.1 mL [− 240.2, − 82.0], − 179.2 mL [− 252.1, − 106.3], − 128.8 mL [− 193.2, − 64.4] at 1, 4, and 12 months after surgery, respectively). Prevalence of postoperative complications was similar between two groups. Perioperative bronchodilator therapy was effective to preserve lung function, after surgery for NSCLC in COPD patients. An active diagnosis and treatment of COPD are required for surgical candidates of NSCLC.Sun Hye ShinSumin ShinYunjoo ImGenehee LeeByeong-Ho JeongKyungjong LeeSang-Won UmHojoong KimO. Jung KwonJong Ho ChoHong Kwan KimYong Soo ChoiJhingook KimJae Ill ZoYoung Mog ShimJuhee ChoDanbee KangHye Yun ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sun Hye Shin Sumin Shin Yunjoo Im Genehee Lee Byeong-Ho Jeong Kyungjong Lee Sang-Won Um Hojoong Kim O. Jung Kwon Jong Ho Cho Hong Kwan Kim Yong Soo Choi Jhingook Kim Jae Ill Zo Young Mog Shim Juhee Cho Danbee Kang Hye Yun Park Effect of perioperative bronchodilator therapy on postoperative pulmonary function among lung cancer patients with COPD
description	Abstract Chronic obstructive pulmonary disease (COPD), an established risk factor for lung cancer, remains largely undiagnosed and untreated before lung cancer surgery. We evaluated the effect of perioperative bronchodilator therapy on lung function changes in COPD patients who underwent surgery for non-small cell lung cancer (NSCLC). From a database including NSCLC patients undergoing lung resection, COPD patients were identified and divided into two groups based on the use of bronchodilator during the pre- and post-operative period. Changes in forced expiratory volume in 1 s (FEV1) and postoperative complications were compared between patients treated with and without bronchodilators. Among 268 COPD patients, 112 (41.8%) received perioperative bronchodilator, and 75% (84/112) were newly diagnosed with COPD before surgery. Declines in FEV1 after surgery were alleviated by perioperative bronchodilator even after adjustments for related confounding factors including surgical extent, surgical approach and preoperative FEV1 (adjusted mean difference in FEV1 decline [95% CI] between perioperative bronchodilator group and no perioperative bronchodilator group; − 161.1 mL [− 240.2, − 82.0], − 179.2 mL [− 252.1, − 106.3], − 128.8 mL [− 193.2, − 64.4] at 1, 4, and 12 months after surgery, respectively). Prevalence of postoperative complications was similar between two groups. Perioperative bronchodilator therapy was effective to preserve lung function, after surgery for NSCLC in COPD patients. An active diagnosis and treatment of COPD are required for surgical candidates of NSCLC.
format	article
author	Sun Hye Shin Sumin Shin Yunjoo Im Genehee Lee Byeong-Ho Jeong Kyungjong Lee Sang-Won Um Hojoong Kim O. Jung Kwon Jong Ho Cho Hong Kwan Kim Yong Soo Choi Jhingook Kim Jae Ill Zo Young Mog Shim Juhee Cho Danbee Kang Hye Yun Park
author_facet	Sun Hye Shin Sumin Shin Yunjoo Im Genehee Lee Byeong-Ho Jeong Kyungjong Lee Sang-Won Um Hojoong Kim O. Jung Kwon Jong Ho Cho Hong Kwan Kim Yong Soo Choi Jhingook Kim Jae Ill Zo Young Mog Shim Juhee Cho Danbee Kang Hye Yun Park
author_sort	Sun Hye Shin
title	Effect of perioperative bronchodilator therapy on postoperative pulmonary function among lung cancer patients with COPD
title_short	Effect of perioperative bronchodilator therapy on postoperative pulmonary function among lung cancer patients with COPD
title_full	Effect of perioperative bronchodilator therapy on postoperative pulmonary function among lung cancer patients with COPD
title_fullStr	Effect of perioperative bronchodilator therapy on postoperative pulmonary function among lung cancer patients with COPD
title_full_unstemmed	Effect of perioperative bronchodilator therapy on postoperative pulmonary function among lung cancer patients with COPD
title_sort	effect of perioperative bronchodilator therapy on postoperative pulmonary function among lung cancer patients with copd
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/93c9c6bf2bf4422dad437790b3874dfa
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Effect of perioperative bronchodilator therapy on postoperative pulmonary function among lung cancer patients with COPD

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